Arbidol powder for suspen detsky 25mg 5ml 125ml
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Active ingredients
Umifenovir
Composition
5 ml of umifenovir hydrochloride monohydrate 25.88 mg, which corresponds to the content of umifenovir hydrochloride 25 mg.
Pharmacological effect
Antiviral agent. It specifically inhibits in vitro influenza A and B viruses (Influenza virus A, B), including the highly pathogenic A (H1N1) pdm09 and A (H5N1) subtypes, as well as other viruses that cause acute respiratory viral infections (Coronavirus) associated with severe acute respiratory syndrome (SARS), rhinovirus (Rhinovirus), adenovirus (Adenovirus), respiratory syncytial virus (Pneumovirus) and parainfluenza virus (Paramyxovirus). The mechanism of antiviral action refers to fusion inhibitors (fusions), interacts with the hemagglutinin of the virus and prevents the fusion of the lipid envelope of the virus and cell membranes. It has interferon-inducing activity - in a study on mice, the induction of interferon was observed already after 16 hours, and high titers of interferon remained in the blood up to 48 hours after administration. Stimulates cellular and humoral immunity reactions: increases the number of lymphocytes in the blood, especially T-cells (CD3), increases the number of T-helper cells (CD4), without affecting the level of T-suppressors (CD8), normalizes the immunoregulatory index, stimulates the phagocytic function of macrophages and increases the number of natural killer cells (NK cells). Therapeutic efficacy in viral infections manifests itself in reducing the duration and severity of the disease and its main symptoms, as well as reducing the incidence of complications associated with viral infection and exacerbations of chronic bacterial diseases. It refers to low-toxic drugs (LD50> 4 g / kg). It does not have any negative effects on the human body when administered orally at recommended doses.
Indications
- prevention and treatment of influenza A and B, other acute respiratory viral infections in children from 2 years and adults. - complex therapy of acute intestinal infections of rotavirus etiology in children from 2 years. - nonspecific prevention of severe acute respiratory syndrome (SARS) in children from 6 years and adults. - treatment of severe acute respiratory syndrome (SARS) in children over 12 years old and adults.
Contraindications
- hypersensitivity to umifenovir or any component of the drug - age up to 2 years - age up to 6 years (according to the indications non-specific prevention of SARS) - age up to 12 years (according to the indications treatment of SARS).- deficiency of sucrase / isomaltase, fructose intolerance, glucose-galactose malabsorption.
Use during pregnancy and lactation
The use of the drug Arbidol during pregnancy is contraindicated. It is not known whether the active substance Arbidol or its metabolites penetrates into breast milk in women during lactation. If necessary, use of the drug Arbidol should stop breastfeeding.
Dosage and administration
Inside, before eating. Preparation of the suspension To the vial containing the powder, add 30 ml (or approximately to 2/3 of the vial volume) of boiled and cooled to room temperature water. Close the vial with a lid, turn it over and shake well until a homogeneous suspension is obtained. Add boiled and cooled water to a volume of 100 ml (up to the mark on the vial) and shake again. Before each use, thoroughly shake the contents of the vial until a homogeneous suspension is obtained. Measure a single dose using the attached measuring spoons. Single dose (depending on age) Age Single dose of the drug, ml of suspension (mg of umifenovir) from 2 to 6 years 10 ml (50 mg) from 6 to 12 years 20 ml (100 mg) over 12 years old and adults 40 ml (200 mg) Indication Dosage regimen In children from 2 years and adults: Non-specific prophylaxis during the epidemic of influenza and other acute respiratory viral infections in a single dose 2 times a week for 3 weeks. Nonspecific prophylaxis in direct contact with patients with influenza and other acute respiratory viral infections in a single dose of 1 time / day for 10-14 days. Treatment of influenza and other acute respiratory viral infections with uncomplicated course in a single dose 4 times / day (every 6 hours) for 5 days. In children from 2 years: Comprehensive treatment of acute intestinal infections of rotavirus etiology in a single dose 4 times / day (every 6 hours) for 5 days. For non-specific prevention and treatment of severe acute respiratory syndrome (SARS) For non-specific prevention of SARS (in contact with patients) in children from 6 years and adults: children from 6 to 12 years old - 20 ml (100 mg), children over 12 years old and adults - 40 ml (200 mg) 1 time per day for 12-14 days. For the treatment of SARS in children from 12 years and adults: children over 12 years old and adults - 40 ml (200 mg) 2 times / day for 8-10 days.
Side effects
Allergic reactions: rarely (with a frequency of at least 1/10 000, but less than 1/1000) - pruritus, rash, angioedema, urticaria. very rarely (with a frequency of less than 1/10 000) - anaphylactic reactions.If any of the side effects indicated in the instructions are exacerbated, or the patient has noticed any other side effects not indicated in the instructions, he should inform the doctor.
special instructions
Allergic reactions: rarely (with a frequency of at least 1/10 000, but less than 1/1000) - pruritus, rash, angioedema, urticaria. very rarely (with a frequency of less than 1/10 000) - anaphylactic reactions. If any of the side effects indicated in the instructions are exacerbated, or the patient has noticed any other side effects not indicated in the instructions, he should inform the doctor.