Etoxydol chewable pills 20 pcs
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Active ingredients
Ethyl methyl hydroxypyridine malate
Release form
Pills
Composition
1 tab. ethyl methyl hydroxypyridine malate 100 mg. Excipients: acetylglutamic acid - 68 mg, deanol - 32 mg, glycine - 20 mg, microcrystalline cellulose 260.
Pharmacological effect
Etoksidol is an inhibitor of free radical processes, has a membrane-protective, antihypoxic, nootropic, anticonvulsant, anxiolytic effect, increases the body's resistance to stress. Etoxydol has anti-ischemic properties, improves blood flow in the ischemic zone, limits the zone of ischemic damage, detects a lipid-lowering effect, reduces the content of total cholesterol and low-density lipoproteins in the blood serum. The drug increases the body's resistance to the effects of various damaging factors, to oxygen-dependent pathological conditions (shock, hypoxia and ischemia, impaired cerebral circulation, intoxication with alcohol and antipsychotics (neuroleptics)). The drug improves brain metabolism and blood supply to the brain, improves microcirculation and rheological properties of blood, reduces platelet aggregation. Stabilizes membrane structures of blood cells (erythrocytes and platelets) during hemolysis. The mechanism of action of the drug due to its antioxidant, antihypoxic and membrane-protective action. It inhibits lipid peroxidation, increases the activity of superoxidase, increases the ratio of lipid-protein, reduces the viscosity of the membrane, increases its fluidity. Modulates the activity of membrane enzymes (calcium-independent phosphodiesterase, adenylate cyclase, acetylcholinesterase) receptor complexes (benzodiazepine, GABA, acetylcholine) that enhances their ability to bind to ligands, promotes preservation of structural and functional organization of biological membranes, transport of neurotransmitters and improve synaptic transmission.
Pharmacokinetics
Absorption: When i / m administration the drug is determined in the blood plasma for 4 hours after administration. TCmax is 0.25 parts. Cmax at a dose of 100 mg is 0.3-1.06 mcg / ml. Etoxydol quickly moves from the bloodstream to organs and tissues and is rapidly eliminated from the body.The retention time of the drug is 1.84-2.38 h. Withdrawal: T1 / 2 is 1.15-1.75 h. Etoxydol is eliminated from the body by the kidneys, mainly in the form of glucuronides and in small quantities in unchanged form.
Indications
- ischemic heart disease (as part of complex therapy) - complex therapy of ischemic stroke - dyscirculatory encephalopathy - mild and moderate cognitive disorders.
Contraindications
- hypersensitivity to the components of the drug - lactose intolerance, lactase deficiency, glucose-galactose malabsorption - acute hepatic and / or renal failure - pregnancy, lactation period - age up to 18 years (efficacy and safety not established).
Use during pregnancy and lactation
Etoxidol is contraindicated during pregnancy and during breastfeeding, as there are no strictly controlled clinical studies on the safety of using the drug during pregnancy and lactation.
Dosage and administration
Tablets Etoxydol prescribed inside. The pills are chewed and washed down with water. For complex therapy of ischemic heart disease and therapy of ischemic stroke, 100 mg (1 tablet) is prescribed 3 times a day, gradually increasing the dose to obtain a therapeutic effect. The maximum single dose - 200 mg: daily - 800 mg. The course is at least 2 months, repeated courses - on the recommendation of a doctor. The duration of treatment and the choice of individual dose depends on the severity of the patient's condition and the effectiveness of treatment. With the complex therapy of light and moderate cognitive disorders, the drug is prescribed without limiting the course of treatment for a duration of 100 mg 3-4 times a day.
Side effects
Usually the drug is well tolerated. In rare cases, allergic reactions, dyspeptic disorders, nausea and dry mouth, diarrhea, which quickly disappear on their own or with drug withdrawal, may occur. With prolonged use may manifest flatulence, sleep disturbances (drowsiness or sleep disturbance).
Overdose
Due to the low toxicity of the drug, overdose is unlikely. In case of an accidental overdose, the symptoms of sleep disturbance may occur - drowsiness, insomnia. Symptomatic treatment.
Interaction with other drugs
Enhances the action of antiepileptic drugs (carbamazepine). anti-parkinsonic agents (levodopa) and benzodiazepine anxiolytics. Increases the anti-anaginal activity of nitropreparatov and hypotensive ACE inhibitors and beta-blockers. Reduces the toxic effects of ethyl alcohol.
special instructions
Impact on the ability to drive motor vehicles and control mechanisms During the period of treatment, care must be taken when driving and engaging in other potentially dangerous activities that require high concentration of attention and speed of psychomotor reactions.