Gastal pills for sucking mint 48 pieces
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Active ingredients
Aluminum hydroxide-magnesium carbonate gel + magnesium hydroxide
Release form
Pills
Composition
1 tablet for resorption contains: Active substances: aluminum hydroxide-magnesium carbonate gel 450 mg, magnesium hydroxide 300 mg, Excipients: mannitol (E421), sorbitol (E420), lactose monohydrate, corn starch, sodium cyclamate, sodium saccharinate, talc, magnesium stearate, peppermint flavoring.
Pharmacological effect
Combined antacid. Reduces the acidity of gastric juice and does not have a stimulating effect on the secretion of gastric juice. Aluminum hydroxide-magnesium carbonate gel and magnesium hydroxide provide immediate (immediately after ingestion) and prolonged (about 2 hours) neutralization of the hydrochloric acid of the gastric juice, while maintaining the acidity in the stomach at a physiological level (pH 3-5). 1 tablet of the drug Gastal neutralizes about 21.5 mmol of hydrochloric acid. Gastal inhibits the action of pepsin, lysolecithin and bile acids, eliminates dyspeptic phenomena. Strengthens protective and regenerative processes in the mucous membrane of the stomach. Aluminum ions have a cytoprotective effect due to increased secretion of mucin and sodium bicarbonate, activation of prostaglandin E2 and NO, accumulation of epidermal growth factor at the site of damage to the mucous membrane, increasing the concentration of phospholipids in the stomach wall.
Pharmacokinetics
Gastal has no systemic effect in patients with normal renal function. After interaction with hydrochloric acid of gastric juice, aluminum hydroxide reacts with phosphates and carbonates in the alkaline medium of the intestine and is excreted in the form of insoluble salts. Magnesium hydroxide reacts with hydrochloric acid in the gastric juice to form magnesium chloride, which has osmotic properties and a mild laxative effect that neutralizes the fixative effect of aluminum hydroxide in the small intestine. Magnesium is excreted in the form of insoluble carbonate.
Indications
Dyspeptic symptoms such as discomfort or pain in the epigastrium, heartburn, acid regurgitation after errors in diet, excessive use of ethanol, coffee, nicotine. Dispepsic phenomena such as discomfort or pain in the epigastrium, heartburn, sour belching (and their prevention) as a result of the use of certain drugs (NSAIDs, GCS). State, accompanied by increased acid production: gastric ulcer, gastritis, reflux esophagitis.hiatal hernia.
Contraindications
Hypersensitivity to the drug components. Severe renal failure. Hypophosphatemia. Fructose intolerance (due to the presence of sorbitol in the formulation). Children's age up to 12 years. With care: at a renal failure (at long reception it is possible increase of content in a blood plasma of magnesium and aluminum). With alzheimer's disease. With a low phosphate content in food (the risk of phosphate deficiency).
Precautionary measures
The drug should be used with caution in chronic renal failure, during pregnancy and during breastfeeding, in adults and children over 12 years old with a body weight less than 50 kg, in children aged 6 to 12 years, in elderly patients.
Use during pregnancy and lactation
The use of the drug during pregnancy and lactation (breastfeeding) is possible only in cases where the intended benefit to the mother outweighs the potential risk to the fetus. Gastal is not excreted in breast milk.
Dosage and administration
Inside, gradually dissolving in the mouth. Adults and children over 12 years old with a body weight of at least 50 kg: 1-2 pills 4-6 times a day approximately 1 hour after meals and at bedtime, but not more than 8 pills per day. The duration of treatment is not more than 2 weeks. Similar doses are recommended for the treatment of heartburn, regardless of the meal. Adults and children over 12 years old weighing less than 50 kg, children aged 6 to 12 years: The dose is half the recommended dose for adults. The duration of treatment is not more than 2 weeks.
Side effects
When using the drug in the recommended doses, adverse reactions are rare (at least 0.01%, but less than 0.1%), nausea, constipation, diarrhea, change in taste. In exceptional cases, allergic reactions are possible.
Overdose
Symptoms of acute overdose are not described. Symptoms: long-term intake in high doses of drugs containing aluminum and magnesium may cause hypophosphatemia, hypocalcemia, hypercalciuria, osteomalacia, osteoporosis, hypermagnemia, hyperaluminemia, encephalopathy, nephrocalcinosis, and kidney function. Possible increased side effects from the digestive system (constipation, diarrhea).In patients with renal insufficiency, thirst, a decrease in blood pressure, and hyporeflexia are possible. Treatment: symptomatic treatment.
Interaction with other drugs
Gastal with simultaneous use enhances the activity of levodopa and nalidixic acid, reduces and slows down the absorption of quinolones, isoniazid, naproxen, iron preparations, indomethacin, aminazine, beta-adrenergic blockers, diflunisal, histamine H2-receptor blockers, H2-receptors, soluble in vitamins, indigestv, indigestin, indigestin, indigestin, blocker, histamine H2-receptors, lipid-soluble vitamins, indigestin, indigestin, indigestin, blockers of histamine H2-receptors, lipid-soluble vitamins, indigestin, indigestin, indigamine, H2-receptor, blockers of histamine H2-receptors, lipid-soluble blockers, industamines When interacting with the metal ions that make up the antacids, tetracyclines form insoluble chelate complexes; As a result of this interaction, the absorption of tetracyclines is reduced by more than 90%. Simultaneous administration of these drugs is not possible. If necessary, the combined use of tetracycline should be taken at least 2 hours before taking an antacid. In the presence of aluminum hydroxide and magnesium hydroxide contained in the Gastal preparation, the absorption of ciprofloxacin and ofloxacin is reduced by 50-90%. In the presence of antacids, bioavailability of captopril is significantly reduced, and the combined use of antacids and metoprolol leads to a decrease in plasma plasma concentration of metoprolol. With the simultaneous use of antacids in high doses, it is possible to reduce the absorption of ranitidine by 10-33%. The use of antacids does not affect the bioavailability of amoxicillin, cefalexin and the combination of amoxicillin and clavulanic acid, but it can significantly reduce the absorption of doxycycline from the gastrointestinal tract. Increasing urine pH during antacid therapy may increase tubular reabsorption of alkaline drugs and reduce reabsorption of acidic compounds. Antacids can reduce and slow down the absorption of salicylates, incl. acetylsalicylic acid, as well as raising the pH of urine, to promote more rapid elimination of salicylates from the body, with a concomitant decrease in their concentration in serum by 30-70%. Absorption of cardiac glycosides, incl. digoxin and digitoxin, while used with antacids is not significantly reduced. M-holinoblokatory, slowing down the motility of the stomach, increase the duration of the drug Gastal.In order to prevent possible interaction of Gastal with other drugs, it is recommended to take it 1 hour before or 1 hour after their use.
special instructions
Do not exceed the recommended dose and duration of treatment when used in patients with impaired renal function. Effect on the ability to drive vehicles and control mechanisms: The use of the drug Gastal does not affect the ability to drive vehicles and control other mechanisms.