Ketoprofen Organika pillspl.ob.100 mg N20
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Active ingredients
Ketoprofen
Release form
Pills
Composition
1 tab. ketoprofen 100 mg. Excipients: sodium benzoate 0.5 mg, disodium edetate 0.5 mg, citric acid monohydrate 1.5 mg, sodium hydroxide to pH 3.2, water d / and up to 1 ml.
Pharmacological effect
NSAID, a derivative of propionic acid. It has an analgesic, anti-inflammatory and antipyretic effect. The mechanism of action is associated with inhibition of the activity of COX - the main enzyme in the metabolism of arachidonic acid, which is a precursor of prostaglandins, which play a major role in the pathogenesis of inflammation, pain and fever. The pronounced analgesic effect of ketoprofen is due to two mechanisms: peripheral (indirectly, through suppression of prostaglandin synthesis) and central (due to inhibition of prostaglandin synthesis in the central and peripheral nervous system, as well as the effect on the biological activity of other neurotropic substances that play a key role in the release of pain mediators in the spinal cord brain). In addition, ketoprofen has anti-bradykinin activity, stabilizes lysosomal membranes, causes significant inhibition of neutrophil activity in patients with rheumatoid arthritis. Suppresses platelet aggregation.
Indications
Articular syndrome (rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, gout). symptomatic treatment of inflammatory-degenerative diseases of the musculoskeletal system (periarthritis, arthrosinovitis, tendonitis, tendosynovitis, bursitis, lumbago), back pain, neuralgia, myalgia. Uncomplicated injuries, in particular sports, sprains, sprain or rupture of ligaments and tendons, bruises, post-traumatic pain. As part of a combination therapy of inflammatory diseases of the veins, lymph vessels, lymph nodes (phlebitis, periphlebitis, lymphangitis, superficial lymphadenitis).
Contraindications
For oral administration: erosive and ulcerative lesions of the gastrointestinal tract in the acute phase, "aspirin triad", marked impaired liver function and / or kidney For rectal use: a history of proctitis and bleeding from the rectum.For external use: weeping dermatosis, eczema, infected abrasions, wounds.
Use during pregnancy and lactation
Contraindicated for use in the III trimester of pregnancy. In the first and second trimester of pregnancy, the use of ketoprofen is possible in cases where the potential benefit to the mother outweighs the potential risk to the fetus. If necessary, the use of ketoprofen during lactation, breastfeeding is recommended to stop.
Side effects
On the part of the digestive system: pain in the epigastric region, nausea, vomiting, constipation or diarrhea, anorexia, gastralgia, abnormal liver function. rarely - erosive and ulcerative lesions of the gastrointestinal tract, bleeding and perforation of the gastrointestinal tract. From the side of the central nervous system: headache, dizziness, tinnitus, drowsiness. On the part of the urinary system: renal dysfunction. Allergic reactions: skin rash. rarely - bronchospasm. Local reactions: when used in the form of suppositories, irritation of the rectal mucosa, painful defecation is possible. when applied in the form of a gel - itching, skin rash at the site of application.
special instructions
On the part of the digestive system: epigastric pain, nausea, vomiting, constipation or diarrhea, anorexia, gastralgia, abnormal liver function. rarely - erosive and ulcerative lesions of the gastrointestinal tract, bleeding and perforation of the gastrointestinal tract. From the side of the central nervous system: headache, dizziness, tinnitus, drowsiness. On the part of the urinary system: renal dysfunction. Allergic reactions: skin rash. rarely - bronchospasm. Local reactions: when used in the form of suppositories, irritation of the rectal mucosa, painful defecation is possible. when applied in the form of a gel - itching, skin rash at the site of application.