Buy Actovegin injection for 40mg ml 10ml N5

Actovegin injection for 40mg ml 10ml N5

Condition: New product

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$66.06

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Active ingredients

Deproteinized dialysate from the blood of dairy calves

Release form

Solution

Composition

Active substance: actovegin concentrate 20 mg, Excipients: sodium chloride, water d / and.

Pharmacological effect

Antihypoxant. Actovegin is hemoderivate, which is obtained by dialysis and ultrafiltration (compounds with a molecular weight of less than 5,000 daltons pass). It has a positive effect on glucose transport and utilization, stimulates oxygen consumption (which leads to stabilization of plasma membranes of cells during ischemia and reduced lactate formation), thus possessing an antihypoxic effect, which begins to manifest itself later than 30 minutes after parenteral administration and reaches a maximum on average after 3 h (2-6 h). Actovegin increases the concentration of ATP, ADP, phosphocreatine, as well as amino acids - glutamate, aspartate and GABA. The effect of the drug Actovegin on the absorption and utilization of oxygen, as well as insulin-like activity with stimulation of glucose transport and oxidation are important in the treatment of diabetic polyneuropathy. In patients with diabetes mellitus and diabetic polyneuropathy, Actovegin reliably reduces the symptoms of polyneuropathy (stabbing pain, burning sensation, paresthesia, numbness of the lower extremities). Disorders of sensitivity are objectively reduced, the mental well-being of patients improves.

Pharmacokinetics

With the help of pharmacokinetic methods, it is impossible to study the pharmacokinetic parameters of the drug Actovegin, since it consists only of physiological components that are usually present in the body. So far, there has been no decrease in the pharmacological effect of hemoderivate in patients with altered pharmacokinetics (for example, hepatic or renal insufficiency, changes in metabolism associated with old age, and also features of metabolism in the newborn).

Indications

Metabolic and vascular disorders of the brain (including ischemic stroke, traumatic brain injury). Peripheral (arterial and venous) vascular disorders and their consequences (arterial angiopathy, trophic ulcers). Wound healing (ulcers of various etiologies, burns, trophic disorders ( bedsores), impaired wound healing processes). Prevention and treatment of radiation injuries of the skin and mucous membranes during radiation therapy.

Contraindications

Hypersensitivity to the drug Actovegin or similar drugs, decompensated heart failure, pulmonary edema, oliguria, anuria, fluid retention in the body. With care: hyperchloremia, hypernatremia.

Precautionary measures

With care: hyperchloremia, hypernatremia.

Use during pregnancy and lactation

The use of the drug in pregnant women did not cause adverse effects on the mother or fetus. However, when used in pregnant women, the potential risk to the fetus must be considered.

Dosage and administration

Depending on the severity of the clinical picture, the initial dose is 10-20 ml / day intravenously or intraarterially; then 5 ml intravenously or 5 ml intramuscularly. Metabolic and vascular disorders of the brain: at the beginning of treatment, 10 ml intravenously daily for two weeks, then 5-10 ml intravenously 3-4 times a week for at least 2 weeks. Ischemic stroke: 20-50 ml in 200-300 ml of the main solution intravenously every day for 1 week, then 10-20 ml intravenously for 2 weeks. Peripheral (arterial and venous) vascular disorders and their consequences: 20-30 ml of the drug in 200 ml of the main solution, intraarterially or intravenously daily; treatment duration is about 4 weeks. Wound healing: 10 ml intravenously or 5 ml intramuscularly daily or 3-4 times a week depending on the healing process (in addition to topical treatment with Actovegin in topical dosage forms). Prevention and treatment of radiation injuries of the skin and mucous membranes during radiation therapy: the average dose is 5 ml intravenously daily during intervals of radiation exposure. Radiation cystitis: daily 10 ml transurethral in combination with antibiotic therapy.

Side effects

Allergic reactions skin rash. skin flushing. hyperthermia, up to anaphylactic shock.

Interaction with other drugs

Currently unknown.

special instructions

In the case of the i / m method of administration, slowly introduce no more than 5 ml. Because of the possibility of an anaphylactic reaction, it is recommended to conduct a test injection (2 ml / m). Solution for injection has a slightly yellowish tint.The color intensity may vary from one batch to another, depending on the characteristics of the raw materials used, but this does not adversely affect the activity of the drug or its tolerance. Do not use an opaque solution or a solution containing particles.

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