Axamon solution in the intramuscular and subcutaneous administration of the introduction. 5mg 1ml N10
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Active ingredients
Ipidacrine
Release form
Solution
Composition
1 ml ipidacrine hydrochloride (in the form of monohydrate) 5 mg. Excipients: sodium citrate, citric acid monohydrate, methyl parahydroxybenzoate, propyl parahydroxybenzoate, ammonium glycyrrhizinate, glycerol 85%, maltitol, acesulfame potassium, grape flavoring 501040А, purified water.
Pharmacological effect
A reversible cholinesterase inhibitor directly stimulates impulse conduction in the neuromuscular synapse and in the central nervous system due to blockade of potassium channels of the membrane. Enhances the effect on smooth muscles not only of acetylcholine, but also of adrenaline, serotonin, histamine and oxytocin. Axamon has the following pharmacological effects: - It improves and stimulates the impulse conduction in the nervous system and neuromuscular transmission. - improves conductivity in the peripheral nervous system, impaired due to injuries, inflammation, exposure to local anesthetics, some antibiotics, potassium chloride, etc. - enhances the contractility of smooth muscle organs under the influence of agonists of acetylcholine, adrenaline, serotonin, histamine and oxytocin receptors, with the exception of potassium chloride. - improves memory, inhibits gradual development of dementia. It has no teratogenic, embryotoxic, mutagenic, carcinogenic and immunotoxic effects. Does not affect the endocrine system.
Indications
- Diseases of the peripheral nervous system: mono- and polyneuropathy, polyradiculopathy, myasthenia and myasthenic syndrome of various etiologies. - diseases of the central nervous system: bulbar paralysis and paresis, the recovery period of organic lesions of the central nervous system, accompanied by motor impairment. - intestinal atony.
Contraindications
- epilepsy - extrapyramidal disorders with hyperkinesis - stenocardia - severe bradycardia - bronchial asthma - mechanical obstruction of the intestine or urinary tract - vestibular disorders - peptic ulcer of the stomach or duodenal ulcer in the acute stage - children's age up to 18 years (there is no systematized data, you have not to apply an item, you have not to apply an item, you have not to learn, you have to apply an exacerbation) - Hypersensitivity to any of the components of the drug.With caution prescribed for gastric ulcer and duodenal ulcer, thyrotoxicosis, diseases of the cardiovascular system, obstructive diseases of the respiratory system in history or in acute diseases of the respiratory tract.
Use during pregnancy and lactation
The use of the drug increases the tone of the uterus and can lead to premature birth, therefore, ipidacrine is contraindicated in pregnancy. Data on the use of the drug during breastfeeding are not available.
Dosage and administration
The drug is injected s / c or / m. Dose and duration of treatment are determined individually, depending on the severity of the disease. Peripheral nervous system diseases Mono- and polyneuropathy of various origins, polyradiculopathy: n / a or intramuscular 5-15 mg 1-2 times / day, a course of 10-15 days (in severe cases up to 30 days). then the treatment is continued with a tablet form of the drug. Myasthenia gravis and myasthenic syndrome: n / a or v / m 15-30 mg 1-3 times / day with a further transition to the tablet form. The general course of treatment is 1-2 months. If necessary, treatment can be repeated several times with a break between courses of 1-2 months. Central nervous system diseases: Bulbar paralysis and paresis: n / a or intramuscular 5-15 mg 1-2 times / day, a course of 10-15 days. then, if possible, switch to tablet form. The recovery period of organic lesions of the central nervous system, accompanied by motor disorders: i / m 10-15 mg 1-2 times / day, a course of up to 15 days. then, if possible, switch to tablet form. Treatment and prevention of intestinal atony: the initial dose - 10-15 mg 1-2 times / day for 1-2 weeks.
Side effects
The frequency of adverse reactions that may occur during the use of the drug is given in the form of the following classification: very frequent (> 1/10 prescriptions), frequent (1 / 10-1 / 100 prescriptions), infrequent (1 / 100-1 / 1000 assignments), rare (1 / 1000-1 / 10 000 assignments), very rare (less than 1/10 000 assignments) and of an unspecified frequency (the frequency cannot be calculated from the available data). On the part of the psyche: infrequent - drowsiness. Of the nervous system: infrequent - dizziness, headache, convulsions. Unspecified frequency - tremor. On the part of the organ of vision: an unspecified frequency - miosis. From the side of the heart: frequent - palpitations, bradycardia. Unspecified frequency - pain behind the sternum.On the part of the respiratory system: infrequent - enhanced secretion of bronchial secretions. On the part of the digestive tract: frequent - salivation, nausea. infrequent - vomiting. rare - diarrhea, pain in the epigastrium. On the part of the liver and biliary tract: an unknown frequency - jaundice. On the part of the skin and subcutaneous tissues: infrequent - itching, rash. General disorders and disorders at the injection site: frequent - increased sweating. infrequent - general weakness. Unknown frequency - hypothermia. Salivation and bradycardia can be reduced by m-anticholinergics (including atropine, cyclodol, metacin). In the event of an itch or rash, you should stop taking the drug. In other cases, reduce the dose or briefly (1-2 days) interrupt the drug.
special instructions
The frequency of adverse reactions that may occur during the use of the drug is given in the form of the following classification: very frequent (> 1/10 prescriptions), frequent (1 / 10-1 / 100 prescriptions), infrequent (1 / 100-1 / 1000 assignments), rare (1 / 1000-1 / 10 000 assignments), very rare (less than 1/10 000 assignments) and of an unspecified frequency (the frequency cannot be calculated from the available data). On the part of the psyche: infrequent - drowsiness. Of the nervous system: infrequent - dizziness, headache, convulsions. Unspecified frequency - tremor. On the part of the organ of vision: an unspecified frequency - miosis. From the side of the heart: frequent - palpitations, bradycardia. Unspecified frequency - pain behind the sternum. On the part of the respiratory system: infrequent - enhanced secretion of bronchial secretions. On the part of the digestive tract: frequent - salivation, nausea. infrequent - vomiting. rare - diarrhea, pain in the epigastrium. On the part of the liver and biliary tract: an unknown frequency - jaundice. On the part of the skin and subcutaneous tissues: infrequent - itching, rash. General disorders and disorders at the injection site: frequent - increased sweating. infrequent - general weakness. Unknown frequency - hypothermia. Salivation and bradycardia can be reduced by m-anticholinergics (including atropine, cyclodol, metacin). In the event of an itch or rash, you should stop taking the drug. In other cases, reduce the dose or briefly (1-2 days) interrupt the drug.