Buy Alka Prim Tablet Bearing N2

Alka Prim Tablet Bearing N2

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Active ingredients

Acetylsalicylic acid + Glycine

Release form



In 1 tablet: acetylsalicylic acid 330 mg; glycine 100 mg. Auxiliary substances: citric acid - 685 mg, sodium bicarbonate - 1685 mg.

Pharmacological effect

NSAIDs of the combined composition, the action of which is determined by the components included in its composition. Acetylsalicylic acid indiscriminately inhibits COX-1 and COX-2, changing the metabolism of arachidonic acid and reducing the synthesis of prostaglandins. It has a pronounced analgesic, antipyretic and anti-inflammatory action. Aminoacetic acid (glycine) is a replaceable amino acid, a central neurotransmitter of inhibitory type of action. It improves the metabolic processes in the brain tissue, providing an antidepressant and sedative effect. It has glycine- and GABA-ergic, alpha1-adreno-blocking, antioxidant and antitoxic action. It regulates the activity of glutamate (NMDA) receptors, due to which it reduces psycho-emotional stress, improves mood, increases mental performance, reduces the severity of vegetative-vascular disorders and the toxic effect of ethanol on the central nervous system. Reduces the acidity of gastric juice to pH 6-7 and reduces the irritating effect of acetylsalicylic acid on the gastrointestinal mucosa.


After ingestion, the drug is rapidly absorbed from the digestive tract. It begins to act after 30 minutes from the moment of ingestion, and the maximum effect occurs after 1-4 hours and is retained for 3-6 hours after a single dose. In patients with normal kidney function 80-100 % of the single dose is excreted in the urine within 24-72 hours.


Alcohol withdrawal syndrome - moderate or mild pain syndrome of different origin: headache, muscle, toothache, menstrual pain, migraine, neuralgia, arthralgia; - increased body temperature for colds and other viral infectious diseases.


Hypersensitivity to acetylism - ulcerative lesions of the gastrointestinal tract (in the acute phase); - pronounced disorders of the liver and kidneys; - simultaneous administration of methotrexate in a dose of 15 mg / week.and more; - pregnancy (I and III trimesters); - lactation period; - the drug is not prescribed to children under 15 years of age with acute respiratory infections caused by viral infections, due to the risk of Reye’s syndrome (encephalopathy and acute fatty liver dystrophy with development of liver failure).

Precautionary measures

With caution, the drug is prescribed for gout, hyperuricemia, gastric ulcer and duodenal ulcer or gastrointestinal bleeding (history), bronchial asthma, COPD, hay fever, nasal polyposis, drug allergy, concurrent use of methotrexate at 15% less 15% II trimester of pregnancy.

Use during pregnancy and lactation

Alka-Prim; should not be used during pregnancy and lactation. Especially it is not recommended to use the drug during the last three months of pregnancy (III trimester) due to possible fetal malformations and complications during labor. If you need to take the drug during lactation, you should stop breastfeeding.

Dosage and administration

Effervescent pills should be dissolved in a glass of water and drunk. Adults and children over 12 years old are recommended for 1-2 tab. 2-4 times / day with an interval of at least 4 hours. The maximum single dose is 1 g (3 tab.). The maximum daily dose for adults, which is not recommended to exceed, is 3 g (9 tab.). Without medical supervision, the drug should not be used for more than 7 days as an analgesic and more than 3 days as an antipyretic.

Side effects

Allergic reactions: skin rash, bronchospasm, angioedema. Formation based on the hapten mechanism of the aspirin triad (a combination of bronchial asthma, recurrent nasal polyposis and paranasal sinuses, and intolerance to acetylsalicylic acid and pyrazolone preparations). From the gastrointestinal tract: nausea, vomiting, epigastric pain, diarrhea. , anemia, leukopenia, hemorrhagic syndrome (epistaxis, bleeding gums), prolonged blood clotting time. With prolonged use in large doses, it may appear ozivno and ulcerative lesions of the gastrointestinal tract, bleeding, black tarry stools, general weakness, interstitial nephritis,prerenal azotemia with increased blood creatinine levels and hyperkalemia, bronchospasm, papillary necrosis, acute renal failure, nephrotic syndrome, aseptic meningitis, increased symptoms of chronic heart failure, edema, increased activity of hepatic transaminase. to the attending physician.


Symptoms: with an overdose of moderate severity, dizziness, hearing and vision impairment, nausea, vomiting, confusion, which disappear after discontinuation of the drug are noted. Severe symptoms of intoxication were observed when taking more than 200 mg / kg: fever, hyperventilation, ketoacidosis, respiratory alkalosis, metabolic acidosis, depression of consciousness up to coma, cardiogenic shock, respiratory failure, severe hypoglycemia. Treatment: should be carried out in a specialized department. It is necessary to induce vomiting or gastric lavage, appoint activated charcoal. Acid-base balance monitoring is recommended, alkalization of urine is recommended in order to obtain a pH of urine of 7.5-8 (forced alkalization of urine is considered to be achieved if salicylic acid concentration in the blood plasma is more than 500 mg / l (3.6 mmol / l) in adults or 300 mg / l (2.2 mmol / l) in children), hemodialysis, compensation for fluid loss, symptomatic therapy.

Interaction with other drugs

Enhances the action of oral anticoagulants and hypoglycemic drugs, insulin, methotrexate, other Pechrs, Pechera, GCS, valproic acid. It weakens the effects of sulfinpyrazone, diflunisal, phenoprofen, ibuprofen, indomethacin, pyroxicam, naproxen, sulindac, etc. agents increase the hematotoxicity of the drug.

special instructions

It is recommended to use the drug under medical supervision to persons suffering from allergic diseases (bronchial asthma, allergic rhinitis, urticaria, pruritus, swelling of the nasal mucosa). When using acetylsalicylic acid in patients receiving antidiabetic drugs,blood sugar levels should be regularly monitored. The combined use of the drug with glucocorticoids, antihypertensive and diuretic drugs requires careful observation. Antacid preparations containing magnesium or aluminum hydroxide should be taken no earlier than 2 hours after taking acetylsalicylic acid. periodically complete blood count and check for blood in the feces. Impact on ability to drive vehicles and control mechanisms: Negate data the effect of Alka-Prim; the ability to drive and perform work requiring increased attention has not been identified.