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Active ingredients
Gabapentin
Composition
Gabapentin 400 mg. Excipients: lactose monohydrate, corn starch, talc. The composition of the capsule shell: titanium dioxide (E171), iron dye yellow oxide (E172), iron dye red oxide (E172), gelatin.
Pharmacological effect
Antiepileptic drug. The chemical structure is similar to GABA, which serves as a brake mediator in the central nervous system. The mechanism of action of gabapentin is believed to be different from other anticonvulsant drugs acting through GABA synapses (including valproate, barbiturates, benzodiazepines, GABA transaminase inhibitors, GABA trapping inhibitors, GABA agonists and GABA prodrugs). In vitro studies have shown that gabapentin is characterized by the presence of a new peptide binding site in rat brain tissues, including the hippocampus and cerebral cortex, which may be related to the anticonvulsant activity of gabapentin and its derivatives. At clinically relevant concentrations, gabapentin does not bind to other conventional drugs and neurotransmitter receptors in the brain, incl. with GABAA-, GABAB-, benzodiazepine receptors, with NMDA-receptors. Finally, the mechanism of action of gabapentin is not installed.
Indications
Treatment of neuropathic pain in adults over the age of 18 years. monotherapy of partial seizures with secondary generalization and without it in adults and children over 12 years. as an additional tool in the treatment of partial seizures with secondary generalization and without it in adults and children aged 3 years and older.
Contraindications
Increased sensitivity to gabapentin.
Use during pregnancy and lactation
Adequate and strictly controlled studies on the safety of gabapentin during pregnancy and lactation in humans have not been conducted. If necessary, use during pregnancy and lactation should carefully weigh the expected benefits of therapy for the mother and the potential risk to the fetus or infant. Gabapentin is excreted in breast milk. When applied during lactation, the nature of the action of gabapentin on an infant has not been established.
Dosage and administration
Individual, depending on the indications and treatment regimen.
Side effects
CNS and peripheral nervous system: amnesia, ataxia, confusion, loss of coordination, depression, dizziness, dysarthria, increased nervous irritability, nystagmus, drowsiness, thinking disorder, tremor, convulsions, amblyopia, diplopia, hyperkinesia, strengthening, weakening or lack of reflexes, paresthesia, anxiety, hostility, gait disturbance. On the part of the digestive system: changes in tooth staining, diarrhea, increased appetite, dry mouth, nausea, vomiting, flatulence, anorexia, gingivitis, abdominal pain, pancreatitis, changes in liver function tests. On the part of the hematopoietic system: leukopenia, a decrease in the number of leukocytes, thrombocytopenic purpura. On the part of the respiratory system: rhinitis, pharyngitis, cough, pneumonia. On the part of the musculoskeletal system: myalgia, arthralgia, bone fractures. Since the cardiovascular system: hypertension, manifestations of vasodilation. On the part of the urinary system: urinary tract infections, urinary incontinence. Allergic reactions: erythema multiforme, Stevens-Johnson syndrome. Dermatological reactions: skin maceration, acne, pruritus, rash. Other: back pain, fatigue, peripheral edema, impotence, asthenia, malaise, swelling of the face, weight gain, accidental injury, asthenia, flu-like syndrome, fluctuations in blood glucose, in children - viral infection, otitis media.
special instructions
CNS and peripheral nervous system: amnesia, ataxia, confusion, loss of coordination, depression, dizziness, dysarthria, increased nervous irritability, nystagmus, drowsiness, thinking disorder, tremor, convulsions, amblyopia, diplopia, hyperkinesia, strengthening, weakening or lack of reflexes, paresthesia, anxiety, hostility, gait disturbance. On the part of the digestive system: changes in tooth staining, diarrhea, increased appetite, dry mouth, nausea, vomiting, flatulence, anorexia, gingivitis, abdominal pain, pancreatitis, changes in liver function tests. On the part of the hemopoietic system: leukopenia, reduction in the number of leukocytes, thrombocytopenic purpura. On the part of the respiratory system: rhinitis, pharyngitis, cough, pneumonia.On the part of the musculoskeletal system: myalgia, arthralgia, bone fractures. Since the cardiovascular system: hypertension, manifestations of vasodilation. On the part of the urinary system: urinary tract infections, urinary incontinence. Allergic reactions: erythema multiforme, Stevens-Johnson syndrome. Dermatological reactions: skin maceration, acne, pruritus, rash. Other: back pain, fatigue, peripheral edema, impotence, asthenia, malaise, swelling of the face, weight gain, accidental injury, asthenia, flu-like syndrome, fluctuations in blood glucose, in children - viral infection, otitis media.