Cytosar lyophilisate for in 1000mg bottle N1

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$36.45

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Active ingredients

Citarabine

Release form

Lyophilisate

Composition

Lyophilisate for preparation of solution for injections 1 fl. Cytarabine 100 mg. Auxiliary substances: 0.1 M hydrochloric acid solution - up to pH 3.0, water d / and - up to 1 ml.

Pharmacological effect

Antitumor agent from the group of pyrimidine antimetabolite analogs. Cytarabine is believed to act by inhibiting DNA polymerase. In addition, it appears to be limitedly incorporated into DNA and RNA.

Indications

Acute nonlymphoblastic leukemias, blast crisis of chronic myeloid leukemia, lymphogranulomatosis, erythromyeosis, neuroleukemia, non-Hodgkin's lymphomas

Contraindications

Myelodepression, pregnancy, hypersensitivity to cytarabine.

Use during pregnancy and lactation

Cytarabine is contraindicated in pregnancy. If necessary, use during lactation should stop breastfeeding. Women of childbearing age should use reliable methods of contraception during treatment with cytarabine. In experimental studies, the teratogenic and embryotoxic effects of cytarabine have been established.

Dosage and administration

They establish individually, depending on the evidence and the stage of the disease, the state of the hematopoietic system, the scheme of antitumor therapy.

Side effects

From the hematopoietic system: thrombocytopenia, anemia, leukopenia. On the part of the digestive system: nausea, vomiting, stomatitis, anorexia. rarely - abnormal liver function, esophagitis, diarrhea, gastrointestinal bleeding. From the side of the central nervous system and peripheral nervous system: paresthesia, unusual tiredness, confusion, memory loss, convulsions, tremor, dysarthria. On the part of the respiratory system: pulmonary edema, diffuse interstitial pneumonitis. On the part of the reproductive system: amenorrhea, azoospermia. Other: cytarabine syndrome, including pain in the bones or muscles, chest pain, fever, general weakness, fever, skin rash (occurs 6-12 hours after administration). conjunctivitis.

special instructions

From the hematopoietic system: thrombocytopenia, anemia, leukopenia. On the part of the digestive system: nausea, vomiting, stomatitis, anorexia. rarely - abnormal liver function, esophagitis, diarrhea, gastrointestinal bleeding. From the side of the central nervous system and peripheral nervous system: paresthesia, unusual tiredness, confusion, memory loss, convulsions, tremor, dysarthria.On the part of the respiratory system: pulmonary edema, diffuse interstitial pneumonitis. On the part of the reproductive system: amenorrhea, azoospermia. Other: cytarabine syndrome, including pain in the bones or muscles, chest pain, fever, general weakness, fever, skin rash (occurs 6-12 hours after administration). conjunctivitis.

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