Derinat solution for local use 0.25% 10ml
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Active ingredients
Sodium deoxyribonucleate
Release form
Solution
Composition
Active ingredient: Sodium deoxyribonucleate (Sodium deoxyribonucleate) Active ingredient concentration (mg): 2, 5 g
Pharmacological effect
Immunomodulator, affecting cellular and humoral immunity. Derinat stimulates reparative processes, has an anti-inflammatory effect, normalizes the state of tissues in case of dystrophic changes in vascular genesis. The drug activates antiviral, antifungal and antimicrobial immunity, has a high reparative and regenerative effect. accelerating epithelization. Under the influence of Derinat, cicatrization of ulcerative defects on the mucous membrane occurs.
Pharmacokinetics
Sodium deoxyribonucleate is rapidly absorbed when applied topically and is distributed through the lymphatic pathways in organs and tissues. Metabolism and excretion Sodium deoxyribonucleate is metabolized in the body. Excreted mainly by the kidneys and partly with feces.
Indications
Monotherapy: - acute respiratory diseases (ARD); - prevention and treatment of acute respiratory viral infections (ARVI); - ophthalmology: inflammatory and dystrophic processes; - inflammatory diseases of the oral mucous membranes; Complex therapy: - chronic inflammatory diseases, fungal, bacterial and other mucosal infections in gynecology; - acute and chronic diseases of the upper respiratory tract (rhinitis, sinusitis, antritis, sinusitis); - obliterating diseases of the lower extremities; - trophic ulcers, no non-healing and infected wounds (including diabetes); - gangrene - burns, frostbite - hemorrhoids - post radial necrosis of the skin and mucous membranes.
Contraindications
Individual intolerance.
Precautionary measures
Do not exceed recommended doses.
Use during pregnancy and lactation
The patient should be warned that a consultation with a physician is necessary before using the drug during pregnancy and lactation. If necessary, the appointment of the drug during pregnancy should assess the expected benefits to the mother and the potential risk to the fetus.
Dosage and administration
Derinat in the form of a solution for external and local use is prescribed depending on the localization of the pathological process. The drug is prescribed to children from the first day of life and adults. For prevention of ARVI they are instilled into each nasal passage 2 drops 2-4 times / day for 1-2 weeks . When symptoms of respiratory disease appear, the drug is instilled 2-3 drops into each nasal passage every 1-1.5 hours during the first day, then 2-3 drops into each nasal passage 3-4 times / day. The duration of therapy is from 5 days to 1 month. In inflammatory diseases of the nasal cavity and paranasal sinuses, the drug is instilled 3-5 drops into each nasal passage 4-6 times / day; the course duration is 7-15 days. In case of inflammatory diseases of the oral cavity, the mouth is rinsed with a solution of the drug 4-6 times / day (1 bottle for 2-3 rinses). The duration of the course of therapy is 5-10 days. In chronic inflammatory diseases, fungal, bacterial and other infections in gynecological practice, intravaginal administration of tampons with the preparation or irrigation of the vagina and cervix 5 ml per procedure 1-2 times / day for 10- 14 days. In hemorrhoids, the drug is administered rectally with microclysters of 15-40 ml. The duration of treatment is 4-10 days. In ophthalmic practice with severe inflammatory and dystrophic processes, Derinat is instilled into the eyes 1-2 drops 2-3 times per day for 14-45 days. For obliterating diseases of the lower extremities in order to achieve a systemic effect The preparation is instilled 1-2 drops in each nasal passage 6 times / day, the duration of the course is up to 6 months. In postradiation necrosis of the skin and mucous membranes, with nonhealing wounds, burns, frostbite, trophic ulcers of various It is recommended to apply application dressings (gauze in 2 layers) with the application of the drug 3-4 times / day or treat the affected surface with the preparation from the sprayer 10-40 ml 4-5 times / day. The course of treatment is 1-3 months.
Side effects
When gangrenous processes under the action of the drug is observed spontaneous rejection of necrotic masses in the foci of rejection with the restoration of the skin. With open wounds and burns, an analgesic effect is observed.
Overdose
So far, no cases of drug overdose Derinat were reported.
Interaction with other drugs
When applied topically, it is incompatible with fat-based ointments and hydrogen peroxide.
special instructions
In the course of numerous experimental and clinical laboratory studies, the absence of mutagenic, teratogenic, embryotoxic, carcinogenic effects, allergenic properties, and cytogenetic effects has been proven; its moderate antimutagenic effect was revealed. In gangrenous processes, under the action of the drug, spontaneous rejection of necrotic masses in the foci of rejection with the restoration of the skin cover is noted. With open wounds and burns, an analgesic effect is noted.