Grippoflu powder for solution raspberry 13g N10
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Active ingredients
Paracetamol + Phenylephrine + Pheniramine
Release form
Powder
Composition
Package 1 contains: Paracetamol 325 mg; phenylephrine hydrochloride 10 mg; Pheniramine Maleate 20 mg; ascorbic acid 50 mg
Pharmacological effect
Combined drug. Paracetamol is a non-narcotic analgesic that acts on the centers of pain and thermoregulation. It has an analgesic and antipyretic effect. Reduces headache and muscle aches, fever effects, soothes sore throats. Pheniramine is an H1-histamine receptor blocker, antiallergic, reduces rhinorrhea and tearing, eliminates spastic phenomena. Phenylephrine is an adrenomimetic with moderate vasoconstrictor action, relieves nasal congestion, and relieves relief from spasmodic effects. Ascorbic acid - is involved in the regulation of redox processes, carbohydrate metabolism, blood clotting, increases the body's resistance to infections, reduces vascular disease. permeability It improves the tolerance of paracetamol and prolongs its action.
Indications
Infectious and inflammatory diseases (ARVI, influenza), accompanied by high fever, chills and fever, headache, runny nose, nasal congestion, sneezing and muscle pain.
Contraindications
Hypertension; diabetes; angle-closure glaucoma; severe diseases of the liver, kidneys, heart, thyroid gland, lungs (including bronchial asthma), bladder; peptic ulcer and duodenal ulcer; pancreatic diseases; difficulty urinating with prostate adenoma; diseases of the blood system; deficiency of the enzyme glucose-6-phosphate dehydrogenase; pregnancy and lactation; children under the age of 12; hypersensitivity to the individual components of the drug.
Precautionary measures
With care: congenital hyperbilirubinemia (Gilbert, Dubin-Johnson and Rotor syndromes), prostatic hyperplasia.
Use during pregnancy and lactation
Contraindicated during pregnancy and lactation.
Dosage and administration
Dissolve the contents of one packet in 1 cup of boiled hot water; consume hot. You can add sugar to taste.A repeated dose can be taken every 4 hours, but not more than 3 doses of the drug for 24 hours. The duration of administration as an antipyretic is no more than 3 days.
Side effects
Allergic reactions (skin rash, itching, urticaria, angioedema), nausea, epigastric pain, anemia, thrombocytopenia, agranulocytosis. Increased excitability, dizziness, increased blood pressure, palpitations, falling asleep. . With long-term use in large doses, there may be hepatotoxic and nephrotoxic effects (renal colic, glycosuria, interstitial nephritis, papillary necrosis), hemolytic anemia, aplastic anemia, methemoglobinemia, pancytopenia.
Overdose
Symptoms (caused by paracetamol): pale skin, loss of appetite, nausea, vomiting; hepatonecrosis. Toxic effects in adults are possible after taking more than 10-15 g of paracetamol, increasing the activity of liver transaminases, increasing the prothrombin time (12-48 hours after ingestion); A detailed clinical picture of liver damage occurs after 1-6 days. Rarely, liver failure develops with lightning speed and may be complicated by renal failure (tubular necrosis). Treatment: the introduction of donators of SH groups and precursors of the synthesis of glutathione-methionine 8–9 hours after overdose and N-acetylcysteine after 12 hours. The need for additional therapeutic measures is determined depending on the concentration of paracetamol in the blood, as well as the time elapsed after its administration.
Interaction with other drugs
Enhances the effects of monoamine oxidase inhibitors, sedative drugs, ethanol. Ethanol enhances the sedative effect of antihistamine drugs. Anti-depressants, anti-Parkinsonian and anti-psyche drugs, phenothiazine derivatives increase the risk of developing urinary retention, dry mouth, constipation. antidepressants increasesympathomimetic action, the simultaneous appointment of halothane increases the risk of ventricular arrhythmias. Reduces the hypotensive effect of guanethidine, which, in turn, enhances the alpha-adrenostimulyuschuyu activity of phenylephrine.
special instructions
Without specifying a doctor, the drug should not be used for pregnant women and nursing mothers, as well as for patients undergoing treatment with other drugs, in particular MAO inhibitors. The drug is not prescribed to children under the age of 12. Influence on ability to drive vehicles and control mechanisms taking the drug is not recommended to drive a car or other mechanisms, to drink alcohol, drugs that depress the central nervous system (hypnotics, tranquilizers, etc.)