Indapamide retard-teva pills with prolonged action 1,5mg N30
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Active ingredients
Indapamide
Release form
Pills
Composition
Tablets of the prolonged action, film coated 1 tab. Indapamide 1.5 mg.
Pharmacological effect
Thiazide-like diuretic, antihypertensive agent. It causes a decrease in the smooth muscle tone of the arteries, a decrease in OPSS, it also has a moderate saluretic activity due to impaired reabsorption of sodium ions, chlorine and water in the cortical segment of the loop of Henle and the proximal convolution of the nephron tubule. The decrease in OPSS is due to several mechanisms: a decrease in the sensitivity of the vascular wall to noradrenaline and angiotensin II. increased synthesis of prostaglandins with vasodilating activity. by inhibiting the influx of calcium ions into the smooth muscle elements of the vascular wall. In therapeutic doses, virtually no effect on lipid and carbohydrate metabolism. The hypotensive effect manifests itself only with initially elevated blood pressure, develops by the end of the first week and reaches a maximum after 3 months of systematic administration.
Indications
Arterial hypertension is the retention of sodium and water in chronic heart failure.
Contraindications
Acute violation of cerebral circulation, pronounced dysfunction of the kidneys and / or liver, severe diabetes and gout, hypersensitivity to indapamide.
Use during pregnancy and lactation
Adequate and well-controlled studies of the safety of indapamide during pregnancy and lactation have not been conducted. Use in this category of patients is not recommended.
Side effects
On the part of the digestive system: nausea, discomfort or epigastric pain. From the side of the central nervous system: weakness, fatigue, dizziness, nervousness. Since the cardiovascular system: orthostatic hypotension. Metabolism: hypokalemia, hyperuricemia, hyperglycemia, hyponatremia, hypochloremia. Allergic reactions: skin manifestations.
special instructions
On the part of the digestive system: nausea, discomfort or epigastric pain. From the side of the central nervous system: weakness, fatigue, dizziness, nervousness. Since the cardiovascular system: orthostatic hypotension.Metabolism: hypokalemia, hyperuricemia, hyperglycemia, hyponatremia, hypochloremia. Allergic reactions: skin manifestations.