Magnesium sulfate - 250 mg
After ingestion, no more than 20% of the accepted dose is absorbed.; Css, at which the anticonvulsant action develops, amounts to 2-3.5 mmol / l. plasma. Excreted by the kidneys, the rate of renal excretion is proportional to the concentration in plasma and the level of glomerular filtration.
Hypertensive crisis; late toxicosis of pregnant women; convulsive syndrome; Relief of epileptic status (as part of complex therapy).
Hypersensitivity to the drug; AV blockade; hypotension; conditions accompanied by calcium deficiency, depression of the respiratory center.
Use during pregnancy and lactation
In pregnancy, magnesium sulfate is used with caution, only in cases where the expected therapeutic effect outweighs the potential risk to the fetus. If necessary, use during lactation breastfeeding should be stopped.
Dosage and administration
V / m or / in. Magnesium sulfate is used only on prescription. Doses specify, taking into account the therapeutic effect and the concentration of magnesium sulfate in the serum.; In hypertensive crises, intramuscular or intramuscular injection is slowly injected in 5–20 ml of a 25% solution. In case of convulsive syndrome, spastic conditions, the drug is prescribed in intramuscular administration by 5–20 ml of a 25% solution in combination with anxiolytic agents with a pronounced central muscle relaxant effect. –10% magnesium sulfate solution.
Early signs and symptoms of hypermagnesemia: bradycardia, diplopia, sudden rush of blood to the face, headache, lowering blood pressure, nausea, shortness of breath, blurred speech, vomiting, weakness. reflexes (2-3.5 mmol / l), prolongation of the PQ interval and expansion of the QRS complex on the ECG (2.5-5 mmol / l), loss of deep tendon reflexes (4-5 mmol / l),oppression of the respiratory center (5-6.5 mmol / l), impaired cardiac conduction (7.5 mmol / l), cardiac arrest (12.5 mmol / l); in addition - hyperhidrosis, anxiety, pronounced sedation, polyuria, uterine atony. , abdominal pain of a spastic nature, thirst, signs of hypermagnesia in the presence of renal failure (dizziness).
Symptoms: respiratory depression is possible, depression of the central nervous system functions, up to the development of anesthesia. Treatment: as an antidote for an overdose of magnesium sulfate, use of calcium - calcium chloride or calcium gluconate.
Interaction with other drugs
When parenteral use of magnesium sulfate and the simultaneous use of peripheral muscle relaxants, the effects of peripheral muscle relaxants are enhanced. With the simultaneous ingestion of antibiotics from the tetracycline group, the effect of tetracyclines can be reduced due to a decrease in their absorption from the gastrointestinal tract. a child with an increased concentration of magnesium in the blood plasma during therapy with magnesium sulfate.; When used simultaneously with nifed Ipine may cause severe muscle weakness.; Reduces the effectiveness of oral anticoagulants (including coumarin derivatives or derivatives of indandion), cardiac glycosides, phenothiazines (especially chlorpromazine). Reduces the absorption of ciprofloxacin, etidronic acid, weakens the effect of streptomycin and tobramycin.; Calcium - calcium chloride or calcium gluconate is used as an antidote for magnesium sulfate overdose; Pharmaceutically incompatible (a precipitate forms) with Ca2 +, ethanol (in high concentrations), carbonates , bicarbonates and phosphates of alkali metals, salts of arsenic acid, barium, strontium, clindamycin phosphate, hydrocortisone sodium succinate, polymyxin B sulfate, procaine hydrochloride, with alicylates and tartrates.
To be taken orally or parenterally with heart block, myocardial damage, chronic renal failure, diseases of the respiratory organs, acute inflammatory diseases of the gastrointestinal tract, pregnancy. CNS. Calcium — calcium chloride or calcium gluconate — is used as an antidote to an overdose of magnesium sulfate.