Buy Thioril coated tablets 25mg N100

Thioril coated pills 25mg N100

Condition: New product

1000 Items


More info

Active ingredients


Release form



Tablets, film coated 1 tab. Thioridazine 25 mg. Excipients: dibasic calcium phosphate (anhydrous), starch, polyvinylpyrrolidone K-30, magnesium stearate, talc.

Pharmacological effect

Antipsychotic (neuroleptic), piperidine derivative of phenothiazine. It has an antipsychotic, moderate sedative effect (without marked lethargy). When used in small doses, has an anxiolytic effect, reduces the feeling of tension and anxiety, has a moderate antidepressant activity. Antiemetic and extrapyramidal action is mild.


Absorption: After ingestion is rapidly absorbed from the digestive tract. The time to reach Cmax in blood plasma is 1-4 hours. Metabolism: Metabolized in the liver. Excretion: T1 / 2 - 6-40 hours. Excreted by the kidneys, with bile.


- schizophrenia - psychotic disorders accompanied by hyperactivity and psychomotor agitation - behavioral disorders associated with psychotic disorders and / or neurological diseases - moderate depressive disorders - neuroses accompanied by anxiety, agitation, stress, fear.


- pronounced depressive states - comatose states - pronounced depression of the central nervous system - blood diseases in history - children's age up to 2 years - severe cardiovascular diseases - liver failure - hypersensitivity to thioridazine and other phenothiazine derivatives.

Use during pregnancy and lactation

Adequate and strictly controlled studies of the safety of the drug during pregnancy has not been conducted. In pregnancy, use of Thioril is only possible if the expected benefit to the mother outweighs the potential risk to the fetus. If necessary, the appointment of Thioril during lactation breastfeeding should be stopped.

Dosage and administration

The dose is set individually, taking into account the genesis of the symptoms and the degree of severity. For adults and children older than 12 years, the dose is 20-600 mg / day, the frequency of use - 2-4 times / day. The maximum dose is 800 mg per day. The course of treatment with high doses continues for no more than 4 weeks.Children aged 2 to 5 years - 1 mg / kg / day. Children older than 5 years are usually prescribed 75 mg / day, the multiplicity of reception - 2-4 times / day.

Side effects

From the side of the central nervous system: drowsiness, confusion, anxiety, akathisia, headache, visual disturbances are possible; in rare cases - neuroleptic malignant syndrome, convulsions (since Tioril can reduce the threshold of convulsive readiness); with prolonged use extrapyramidal disorders, late dyskinesias are possible. On the part of the organ of vision: in high doses more often than other phenothiazines, it causes pigmentary retinopathy. On the part of the digestive system: possible dry mouth, constipation, nausea, vomiting, hypertrophy of the papillae of the tongue, rarely - paralytic ileus, cholestatic hepatitis. Since the cardiovascular system: possible postural hypotension (especially in elderly patients), cardiac arrhythmias, tachycardia; in high doses (like other phenothiazines), especially with concomitant hypokalemia, can cause ECG changes - prolongation of the QT interval, smoothing of the T wave, appearance of the U wave. On the part of the hematopoietic system: in rare cases - leukopenia, agranulocytosis, thrombocytopenia, aplastic anemia, granulocytopenia, eosinophilia, pancytopenia. On the part of the endocrine system: possible hyperprolactinemia, menstrual disorders, impaired ejaculation, decreased libido. On the part of the metabolism: with prolonged use in high doses may develop melanosis. On the part of the respiratory system: nasal congestion. Allergic reactions: skin rash, itching, angioedema, exfoliative dermatitis are possible. Other: possible incontinence or urinary retention; rarely - weight gain, photophobia, visual impairment.


Symptoms: increased drowsiness, confusion, urinary retention, depression of the respiratory center, hypotension, disorientation, areflexia, hyperreflexia, convulsions, arrhythmia. In severe cases, coma, collapse. Treatment: gastric lavage, followed by the appointment of activated carbon. Symptomatic treatment, with arterial hypotension, administration of plasma substitutes is indicated.

Interaction with other drugs

With simultaneous use of Thioril with other drugs that have a depressant effect on the central nervous system, as well as ethanol and ethanol-containing drugs, CNS depression may increase; with levodopa - reduction of anti-parkinsonian action; with lithium preparations - perhaps a neurotoxic effect. Thioryl can lower plasma concentrations of phenobarbital, reduce the effects of anticoagulants and oral antidiabetic agents. The undesirable anticholinergic effect of Thioril may be enhanced while being used with anticholinergic drugs.

special instructions

It is used with caution in patients with heart rhythm disorders, heart diseases, severe respiratory diseases, renal failure, Parkinson's disease, angle-closure glaucoma, prostate hypertrophy, myasthenia, epilepsy, pheochromocytoma. Patients with liver disease require regular monitoring of liver function. Elderly patients who are debilitated or suffering from kidney or liver disease are advised to prescribe the drug in a low initial dose with a gradual increase. During the period of treatment to prevent the use of alcohol. Impact on the ability to drive vehicles and control mechanisms: During the period of treatment should refrain from potentially hazardous activities that require increased attention and quick psychomotor reactions.