Almagel suspension for oral administration 170 ml
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Active ingredients
Algeldrat + Magnesium hydroxide
Composition
5 ml (1 scool) alladrat (aluminum hydroxide gel) 2.18 g, which corresponds to an aluminum oxide content of 218 mg magnesium hydroxide paste 350 mg, which corresponds to a magnesium content of oxide 75 mg Auxiliary substances: sorbitol - 801.15 mg, gietelloza - 10.9 mg, methyl parahydroxybenzoate - 10.9 mg, propyl parahydroxybenzoate - 1.363 mg, butyl parahydroxybenzoate - 1.363 mg, sodium saccharinate dihydrate - 818 μg, lemon oil - 1.635 mg, ethanol 96% - 98.1 mg, purified water - up to 5 ml.
Pharmacological effect
Antacid preparation, which is a balanced combination of allegrite (aluminum hydroxide) and magnesium hydroxide. Neutralizes free hydrochloric acid in the stomach, reduces the activity of pepsin, which leads to a decrease in the digestive activity of gastric juice. It has an enveloping, adsorbing effect. It protects the gastric mucosa by stimulating the synthesis of prostaglandins (cytoprotective effect). It protects the mucosa from inflammatory and erosive hemorrhagic lesions as a result of the use of irritating and ulcerogenic agents such as ethanol, NSAIDs (for example, indomethacin, diclofenac, acetylsalicylic acid), corticosteroids. The therapeutic effect after taking the drug occurs in 3-5 minutes. The duration of action depends on the rate of gastric emptying. When taken on an empty stomach, the effect lasts up to 60 minutes. When taken an hour after eating, the antacid effect can last up to 3 hours. It does not cause secondary hypersecretion of gastric juice.
Pharmacokinetics
Algeldrat: A small amount of the drug is absorbed, which practically does not change the concentration of aluminum salts in the blood. Excreted through the intestines. Magnesium hydroxide: Magnesium ions are absorbed in small amounts (about 10% of the dose taken) and do not change the concentration of magnesium in the blood. Distributed usually locally. Magnesium hydroxide is excreted through the intestines.
Contraindications
- severe renal failure (due to the risk of hypermagnesium and aluminum intoxication) - Alzheimer's disease - hypophosphatemia - pregnancy - children under 10 years old - congenital fructose intolerance (the drug contains sorbitol) - hypersensitivity to active substances and auxiliary components of the drug.
Use during pregnancy and lactation
Experimental studies in animals have shown no teratogenic potential or other undesirable effects on the embryo and / or fetus. There is no clinical data on the use of the drug Almagel in pregnant women. The drug is not recommended for use in pregnancy, but if the intended benefit to the mother outweighs the potential risk to the fetus, Almagel should be taken under the supervision of a doctor for no more than 5-6 days. There is no data on the release of the active substances of the drug in breast milk. Almagel can be used during breastfeeding only after a careful assessment of the ratio of the intended benefits to the mother and the potential risk to the baby. During lactation, the drug is recommended to use no more than 5-6 days under the supervision of a physician.
Dosage and administration
The drug is taken orally. Before each use, the suspension must be thoroughly homogenized by shaking the bottle. Treatment The drug is taken 45-60 minutes after a meal and in the evening before bedtime. Adults and children over 15 years old are prescribed 5-10 ml (1-2 scoops) 3-4 times / day. If necessary, a single dose can be increased to 15 ml (3 scoops). Children aged 10 to 15 years prescribed in a dose equal to half the dose for adults. After reaching a therapeutic effect, the daily dose is reduced to 5 ml (1 scoop) 3-4 times / day for 15-20 days. It is not recommended to take fluids for 15 minutes after taking Almagel. Prevention On 5-15 ml for 15 min. Before taking medication with irritant action.
Side effects
On the part of the digestive system: perhaps - constipation, which passes after a dose reduction in rare cases - nausea, vomiting, stomach cramps, change in taste. On the part of the nervous system: with prolonged use of the drug in patients with renal insufficiency and patients on dialysis, changes in mood and mental activity are possible. Others: in rare cases - allergic reactions and hypermagnesia with prolonged use in high doses (in combination with a deficiency of phosphorus in food), osteomalacia may develop.
Overdose
Symptoms: with a single overdose - constipation, flatulence, metallic taste in the mouth. With prolonged use in high doses, the formation of kidney stones, the development of severe constipation, slight drowsiness, hypermagnemia.There may also be signs of metabolic alkalosis: changes in mood or mental activity, numbness or pain in the muscles, irritability and fatigue, slowing breathing, unpleasant taste sensations. Treatment: it is necessary to take immediate steps to quickly remove the drug from the body - gastric lavage, stimulation of vomiting, taking activated charcoal.
Interaction with other drugs
It can adsorb some drugs, thus reducing their absorption. Therefore, with the simultaneous use of other drugs, it is necessary to observe the interval of 1-2 hours between taking the drug Almagel and other means. Almagel changes the pH of the gastric juice in the alkaline direction, which can affect the action of a significant number of drugs with simultaneous use. Almagel reduces the effect of histamine H2-receptor blockers (cimetidine, ranitidine, famotidine), cardiac glycosides, iron salts, lithium preparations, quinidine, mexiletine, phenothiazine preparations, tetracycline antibiotics, ciprofloxacin, isoniazid and ketoconazaz With the simultaneous appointment of enteric forms of drugs should be remembered that the increase in the pH of gastric juice, caused by taking the drug Almagel, can lead to accelerated destruction of the enteric membrane and thereby cause irritation of the mucous membrane of the stomach and duodenum. Almagel may affect the results of some laboratory and functional studies and tests: reduces the level of gastric secretion in determining the acidity of gastric juice changes test results using technetium (99mTc), for example, bone scintigraphy and some tests for the study of the esophagus increases the serum phosphorus concentration, changes pH values of serum and urine.
special instructions
It is not recommended to use the drug in patients with severe constipation, with pain in the stomach of unknown origin and suspected acute appendicitis, the presence of ulcerative colitis, diverticulosis, colostomy or ileostomy, chronic diarrhea, acute hemorrhoids, changes in acid-base balance in the body, as well as metabolic alkalosis, cirrhosis of the liver, severe heart failure, toxicosis of pregnant women, impaired renal function ((CC less than 30 ml / min) due to the risk of hypermagneemia and aluminum intoxication).In patients with renal failure with prolonged use of the drug (more than 20 days), regular monitoring of serum magnesium concentration is necessary. The drug does not contain sugar, which allows you to take it to patients with diabetes. The drug contains sorbitol, therefore it is contraindicated in cases of congenital fructose intolerance. Influence on the ability to drive vehicles and control mechanisms Almagel does not affect the ability to drive and work with mechanisms. When taken in the recommended daily dose, the ethanol contained in the preparation does not affect the ability to drive a car and work with mechanisms.