Amixin coated pills 60mg N10
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Active ingredients
Tiloron
Release form
Pills
Composition
Active ingredient: TiloronActivating substances: potato starch, microcrystalline cellulose, povidone (collidon 30), calcium stearate, croscarmellose sodium (primelloza). Active ingredient concentration (mg): 60 mg
Pharmacological effect
Low molecular weight synthetic interferon inducer, stimulating the formation in the body of interferon alpha, beta, gamma. The main structures producing interferon in response to the administration of tilorone are intestinal epithelial cells, hepatocytes, T lymphocytes, neutrophils and granulocytes. After taking the drug inside the maximum of interferon production is determined in the sequence of the intestine-liver-blood after 4-24 hours. Amixin has an immunomodulatory and antiviral effect. In human leukocytes induces the synthesis of interferon. Stimulates bone marrow stem cells, enhances antibody production, depending on the dose, reduces the degree of immunosuppression, restores the ratio of T-suppressors and T-helpers. Effective against various viral infections (including those caused by influenza viruses, other causative agents of acute respiratory viral infections, hepatitis viruses, herpes). The mechanism of antiviral action is associated with the inhibition of translation of virus-specific proteins in infected cells, as a result of which reproduction of viruses is inhibited.
Pharmacokinetics
AbsorptionAfter taking the drug inside, tiloron is rapidly absorbed from the gastrointestinal tract. Bioavailability is about 60%. Distribution: Binding to plasma proteins is about 80%. Metabolism and elimination of Thyloron does not undergo biotransformation and does not accumulate in the body. It is eliminated almost unchanged with feces (about 70%) and urine (about 9%). T1 / 2 is 48 hours.
Indications
In adults, for the prevention and treatment of influenza and ARVI; - for the treatment of viral hepatitis A, B and C; - for the treatment of herpes infection; - for the treatment of cytomegalovirus infection; - as part of complex therapy of allergic and viral encephalomyelitis (including multiple sclerosis, leukoencephalitis, uveoencephalitis); - as part of complex therapy of urogenital and respiratory chlamydia; - as part of complex treatment of pulmonary tuberculosis. In children over 7 years old - for the treatment of influenza and ARVI.
Contraindications
- pregnancy; - breastfeeding period; - children's age up to 7 years; - Hypersensitivity to the drug.
Precautionary measures
Do not exceed recommended doses.
Use during pregnancy and lactation
Amixin contraindicated for use during pregnancy and during breastfeeding.
Dosage and administration
The drug is taken orally after a meal. In adults, for nonspecific prophylaxis of viral hepatitis A, the drug is prescribed at a dose of 125 mg once a week for 6 weeks. Course dose - 750 mg (6 tab.). In the treatment of viral hepatitis A, the dose of the drug on the first day is 125 mg 2 times / day, then switch to 125 mg in 48 hours. The course of treatment is 1. 25 g (10 tab.). In the treatment of acute hepatitis B in the initial phase of treatment on the first and second day, the dose of the drug is 125 mg / day, and then 125 mg in 48 hours. The course of treatment is 2 g (16 tab.). With a prolonged course of hepatitis B on the first day, the dose of the drug is 125 mg 2 times / day, then 125 mg in 48 hours. The course dose is 2. 5 g (20 tab.). In chronic hepatitis B in the initial phase of treatment, the total dose is 2. 5 g (20 tab.). In the first 2 days, the daily dose is 250 mg, then switch to 125 mg in 48 hours. In the continuation phase of treatment, the total dose is from 1. 25 g (10 tab.) To 2. 5 g (20 tab.), While the drug administered at a dose of 125 mg per week. The course dose of Amixin varies from 3. 75 to 5 g, the duration of treatment is 3. 5-6 months, depending on the results of biochemical, immunological and morphological studies, reflecting the degree of activity of the process. In acute hepatitis C, on the first and second day of treatment, Amixin is prescribed at a dose of 125 mg / day, then 125 mg after 48 hours. The course dose is 2. 5 g (20 tab.). In chronic hepatitis C in the initial phase of treatment, the total dose is 2. 5 g (20 tab.). In the first 2 days, the drug is taken at a dose of 250 mg / day, then 125 mg at 48 hours. In the continuation phase of treatment, the total dose is 2. 5 g (20 tab.), While the drug is administered at a dose of 125 mg per week. The course dose Amixin - 5 g (40 tab.), The duration of treatment is 6 months depending on the results of biochemical, immunological and morphological studies, reflecting the degree of activity of the process. With the complex treatment of neurovirus infections - 125-250 mg / day for the first two days of treatment, then 125 mg after 48 hours. The dose is set individually, the duration of treatment is 3-4 weeks. For the treatment of influenza and other acute respiratory viral infections in the first 2 days of the disease, Amixin is prescribed at a dose of 125 mg / day, then 125 mg after 48 hours. The course dose is 750 mg (6 tab.).For the prevention of influenza and ARVI Amixin prescribed in a dose of 125 mg 1 time per week for 6 weeks. Course dose - 750 mg (6 tab.). For the treatment of herpes, cytomegalovirus infection the dose of the drug in the first 2 days is 125 mg, then take 125 mg in 48 hours. The course dose is 1. 25-2. 5 g (10-20 tab.). In urogenital and respiratory chlamydia, Amixin is prescribed at a dose of 125 mg / day for the first 2 days, then 125 mg each after 48 hours. The course dose is 1. 25 g (10 tab.). With the complex therapy of pulmonary tuberculosis in the first 2 days, the drug is prescribed at 250 mg / day, then 125 mg at 48 hours. The course dose is 2. 5 g (20 tab.). For children over 7 years old with uncomplicated forms of influenza or other acute respiratory viral infections, the drug is prescribed at a dose of 60 mg (1 tab.) 1 time / day after meals on the 1st, 2nd and 4th day from the start of treatment. Heading dose - 180 mg (3 tab.). With the development of complications of influenza and other acute respiratory viral infections, the drug is taken 60 mg 1 time / day on the 1st, 2nd, 4th, 6th day from the start of treatment. Heading dose - 240 mg (4 tab.).
Side effects
On the part of the digestive system: possible symptoms of dyspepsia. Other: possible short-term chills, allergic reactions.
Overdose
To date, cases of overdose Amixin unknown.
Interaction with other drugs
There are no clinically significant drug interactions of Amixin with antibiotics and traditional treatments for viral and bacterial infections.
special instructions
Amixin is compatible with antibiotics and traditional treatment of viral and bacterial infections.