Cerebrolysin injection solution ampoules 20 ml 5 pcs
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Active ingredients
Cerebrolysin concentrate
Composition
1 ml complex of peptides * derived from the brain of a pig 215.2 mg. Excipients: sodium hydroxide, water d / and.
Pharmacological effect
Nootropic drug. Cerebrolysin contains low molecular weight biologically active neuropeptides that penetrate through the BBB and directly reach the nerve cells. The drug has an organ-specific multimodal effect on the brain, i.e. provides metabolic regulation, neuroprotection, functional neuromodulation and neurotrophic activity. Metabolic regulation: the drug Cerebrolysin increases the efficiency of the aerobic energy metabolism of the brain, improves intracellular protein synthesis in the developing and aging brain. Neuroprotection: the drug protects neurons from the damaging effect of lactic acidosis, prevents the formation of free radicals, increases survival and prevents neuron death in conditions of hypoxia and ischemia, reduces the damaging neurotoxic effect of excitatory amino acids (glutamate). Neurotrophic activity: the drug Cerebrolysin is the only nootropic peptidergic drug with proven neurotrophic activity, similar to the action of natural neuronal growth factors (NGF), but manifested in the conditions of peripheral administration. Functional neuromodulation: the drug has a positive effect in cases of cognitive impairment on the memory processes.
Pharmacokinetics
The complex composition of Cerebrolysin, the active fraction of which consists of a balanced and stable mixture of biologically active oligopeptides with a total polyfunctional effect, does not allow for the usual pharmacokinetic analysis of individual components.
Indications
- as part of the complex therapy of cerebrovascular insufficiency (dyscirculatory encephalopathy - ischemic stroke (acute phase and rehabilitation stage) - condition after hemorrhagic stroke - traumatic brain damage (concussion, traumatic brain injury, condition after surgery on the brain) - encephalopathy, brain encephalopathy, - encephalopathy, brain encephalopathy. - myelopathy - neuropathy - radiculopathy of various origins (infectious, toxic, traumatic) - cerebral palsy - reduction of con focus on children.
Contraindications
- pronounced renal dysfunction - epileptic status - pregnancy - hypersensitivity. With care: the drug is prescribed during lactation.
Use during pregnancy and lactation
Contraindicated in pregnancy. With care: the drug is prescribed during lactation.
Dosage and administration
Introduced intramuscularly in 1-5 ml daily or every other day. The course of treatment is 20 injections. After a 3-6 month break, treatment with cerebrolysate can be repeated (after consulting a doctor). In neuropediatric practice - intramuscularly, 1-2 ml (up to 1 ml per 10 kg of body weight) for 10-15 days, with a course repeated 2-3 times a year.
Side effects
Injections of the drug in some cases cause local pain, irritation, hyperemia. Allergic reactions, increased blood pressure (with concomitant arterial hypertension) are possible.
Overdose
Currently, no cases of overdose have been reported.
Interaction with other drugs
With the simultaneous use of Cerebrolysin with antidepressants or MAO inhibitors, mutual enhancement of their action is possible. In such cases, it is recommended to reduce the dose of antidepressant. Pharmaceutical interaction Cerebrolysin is incompatible with solutions containing lipids and with solutions that change the pH of the medium (5.0-8.0).
special instructions
Precautions should be prescribed the drug for allergic diathesis, epilepsy.