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Active ingredients
Cinnarizine
Release form
Pills
Composition
Active ingredient: Cinnarizine (cinnarizine) Active ingredient concentration (mg): 25
Pharmacological effect
Cinnarizine improves cerebral and peripheral circulation by inhibiting the action of a number of endogenous vasoconstrictors and the flow of calcium ions into cells through the blockade of slow voltage-dependent calcium channels. It has a vasodilating effect especially in relation to the vessels of the brain, without having a significant effect on hell. increases the elasticity of erythrocyte membranes, their ability to deform, reduces blood viscosity, increases muscle resistance to hypoxia. shows moderate antihistamine activity, reduces the excitability of the vestibular apparatus, lowers the tone of the sympathetic nervous system.
Pharmacokinetics
Absorbed relatively slowly in the digestive tract. Cmax in plasma is achieved 1-3 h after oral administration. Associated with plasma proteins by 80%, with erythrocytes by 13%. The distribution in the tissues is more intense within 4 hours after ingestion. Fully metabolized in the liver, mainly by N-dealkylation. T1 / 2 is 3-6 hours, it is displayed in the form of metabolites: 1/3 - by the kidneys and 2/3 - with feces.
Indications
Adults and children over 12 years: - the prevention and treatment of disorders of the peripheral circulation (artery occlusive disease, obliterirutoschy thromboangiitis, Raynaud's disease, diabetic angiopathy, thrombophlebitis, trophic disorders (trophic and varicose ulcers), paresthesia, nocturnal cramps and cooling in the limbs); - Prevention Kinetozov (road sickness - sea and air sickness); - symptomatic treatment of labyrinth and vestibular disorders of vascular origin, Meniere's disease.
Contraindications
Pregnancy; - lactation period; - children's age up to 12 years; - lactase deficiency, galactosemia or glucose-galactose malabsorption syndrome; - celiac disease (gluten enteropathy); - hypersensitivity to the components of the drug.
Precautionary measures
In a dry and dark place at a temperature not higher than 25 ° C. Keep out of the reach of children!
Use during pregnancy and lactation
Due to the lack of well-controlled clinical studies on the safety of use in pregnant women, the use of cinnarizine during pregnancy is not recommended. Due to the lack of data regarding excretion into breast milk, the use of cinnarizine during breastfeeding is undesirable. In cases where the use of the drug is necessary, feeding with the food should be stopped.
Dosage and administration
Adults and children older than 12 years Inside, with a large amount of liquid, after eating. In case of violation of the peripheral circulation - 50-75 mg (2-3 tab /) 3 times / day. In case of high sensitivity to the drug, the treatment starts with 1/2 dose, increasing it gradually. To achieve the optimal therapeutic effect, the drug should be taken continuously, for a long time - from several weeks to several months. For vestibular disorders - 25 mg 3 times / day / For kinetosis - 25 mg 30 minutes before the upcoming road (if necessary, repeat 25 mg after 6-8 hours). For labyrinth disorders - 25 mg 3 times / day. The maximum daily dose should not exceed 225 mg.
Side effects
The most common side effects are drowsiness, gastrointestinal discomfort, which in most cases are transient in nature and take place when the dose is reduced. Other less common side effects: Cardiovascular: decreased blood pressure. From the nervous system: headache, increased fatigue; in patients taking high doses of cinnarizine, ectraliamid symptoms (tremor of the limbs and increased muscle tone, hypokinesia, disorientation, imbalance), including Parkinson's syndrome, depression are possible. From the alimentary system: dry mouth, epigastric pain dyspepsia; extremely rarely - cholestatic jaundice. From the side of the skin: excessive sweating; in extremely rare cases - lichen planus and lupus-like reactions. Allergic reactions: skin rash. Others: weight gain.
Overdose
Symptoms: vomiting, drowsiness, decreased blood pressure, tremor, coma. Treatment: in cases of overdose - gastric lavage, activated charcoal. Symptomatic remedies are used.There is no specific antidote.
Interaction with other drugs
Enhances the effect of ethanol (alcohol) and sedative drugs. When used simultaneously with nootropic, hypotensive and vasodilators, it enhances their effect. Reduces the effect of hypertensive drugs.
special instructions
Cinnarizine can cause gastric discomfort. Taking pills after a meal reduces irritation of the gastric mucosa. Patients suffering from Parkinson's disease should be prescribed cinnarizine only if its benefits exceed the potential risk of deterioration. Patients over 65 years old who have extrapyramidal disorders in the family history or clinical symptoms should have extrapyramidal disorders. under constant medical supervision. In persons prone to lowering blood pressure (hypotension), blood pressure values must be monitored during treatment. Cinnarizine can cause false positive r action during sportsmenov.Pri doping tests in long-term use is recommended to perform the control of the liver function examination, renal, peripheral picture krovi.Vvidu cinnarizine their antihistaminic effects may lead to false negative results in skin samples of the increased sensitivity. Treatment of cinnarizitum should be canceled 4 days before the study. Effect on ability to drive vehicles and control mechanisms. During the period of treatment, care must be taken when driving vehicles and practicing potentially hazardous activities that require increased concentration and psychomotor reactions.