Cortexin powder lyophilisate injection vial 5mg N10
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Active ingredients
Cattle Bark Polypeptides
Release form
Solution
Composition
Active ingredient: Cortexin (complex of water-soluble polypeptide fractions) Active substance concentration (mg): 5 mg
Pharmacological effect
Nootropic drug. Contains a complex of low molecular weight water-soluble polypeptide fractions, penetrating through the BBB directly to the nerve cells. The drug has a nootropic, neuroprotective, antioxidant and tissue-specific effect. Neurotropic effect: improves higher brain functions, learning and memory processes, concentration, resistance to various stress effects. Neuroprotective effect: protects neurons from damage by various endogenous neurotoxic factors (glutamate, calcium ions , free radicals), reduces the toxic effects of psychotropic substances. Antioxidant effect: inhibits lipid peroxidation neurons, increases the survival of neurons in conditions of oxidative stress and hypoxia. Tissue-specific action: activates the metabolism of neurons of the central and peripheral nervous system, reparative processes, improves the function of the cerebral cortex and the overall tone of the nervous system. The mechanism of action The mechanism of action of the drug Cortexin is due to the activation of neuronal and neurotrophic peptides brain factors; optimizing the balance of metabolism of excitatory and inhibitory amino acids, dopamine, serotonin; GABA-ergic effect; a decrease in the level of paroxysmal convulsive activity of the brain, the ability to improve its bioelectric activity; preventing the formation of free radicals (lipid peroxidation products).
Pharmacokinetics
The composition of the drug Cortexin, the active substance of which is a complex of polypeptide fractions, does not allow the usual pharmacokinetic analysis of individual components.
Indications
Neuroinfections (bacterial and viral), cerebrovascular accident, traumatic brain injury, encephalopathy of various etiologies, asthenic syndrome, in the complex therapy of encephalitis and encephalomyelitis (acute and chronic forms), epilepsy (as part of complex therapy), supersegmental autonomic disorders, as well as out-of-operation vegetative disorders. thinking, memory, reduced ability to learn, cerebral palsy, delayed speech and psychomotor development in children
Contraindications
In the case of indications in the history of allergic reactions to Cortexin and other components of the drug.
Precautionary measures
Do not exceed recommended doses.
Use during pregnancy and lactation
The drug is contraindicated for use during pregnancy (due to the lack of data from clinical studies). If necessary, the use of the drug during lactation should stop breastfeeding (due to lack of data from clinical studies).
Dosage and administration
Designed for intramuscular administration. The contents of 1 bottle before the introduction of dissolve in 1-2 ml of solvent. As a solvent, you can use water for injection, or 0.9% sodium chloride solution, or 0.5% solution of procaine. Enter once a day for adults 10 mg course of 5-10 days. In pediatrics: for children with a body weight above 20 kg - an adult dosage, for children up to 20 kg (can be prescribed from the first days of life) - 5 mg 1 time per day. The course of treatment is 5-10 days. If necessary, the course of administration of Cortexin can be repeated after 1-6 months.
Side effects
Hypersensitivity reactions are possible (rarely).
Overdose
Currently, no cases of overdose have been reported.
Interaction with other drugs
Drug interaction of the drug Cortexin is not described.
special instructions
Cortexin should be used only as prescribed by a doctor. When using 0.5% procainum solution (novocaine) as a solvent for Cortexin, adhere to information about contraindications, precautions and age restrictions set out in the instructions for use of procaine (novocaine). drug can not be stored and used after storage. The drug Cortexin is not recommended to be mixed with other solutions. Features of the drug the drug is not available at the first dose or when it is canceled. In case of missing an injection, it is not recommended to inject a double dose, but to carry out the next injection as usual on the scheduled day. Special precautions when destroying unused drugs are not required. Impact on the ability to drive vehicles and control mechanismsNo data.