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Active ingredients
Mometasone
Release form
Lotion
Composition
Active ingredient: Mometasone; Concentration of active ingredient (%): 0.1%
Pharmacological effect
Mometasone is a synthetic HX, which has anti-inflammatory, antipruritic and antiexudative action. CGs induce the release of proteins that inhibit phospholipase a2 and commonly known as lipocortins, which control the biosynthesis of inflammatory mediators such as prostaglandins and leukotrienes, by inhibiting the release of their common precursor, arachidonic acid.
Pharmacokinetics
Absorption of Elocom Lotion (0.1% solution for external use) is insignificant. Eight hours after application to intact skin (without an occlusive dressing), about 0.7% is found in the systemic circulation.
Indications
The drug is used for skin diseases requiring treatment with glucocorticosteroids, including: - Symptomatic treatment of inflammation and itching for skin and allergic diseases; - Treatment of psoriasis, atopic and seborrheic dermatitis; - Lichen planus, radiation radiation dermatitis.
Contraindications
Increased individual sensitivity to the components of the drug. The drug is not used in ophthalmic practice.
Precautionary measures
The drug should be stored at a temperature of 2 to 25 ° C out of the reach of children.
Use during pregnancy and lactation
The use of this agent during pregnancy for the treatment of large areas of skin and / or long-term treatment is prohibited. The use of this agent during lactation is prohibited (use in large doses or / and for a long time).
Dosage and administration
Ointment, cream: The drug is used 1 time per day. Ointment or cream is applied with a thin layer to the affected skin. The course of treatment is determined individually for each patient depending on the severity of the disease. Lotion: The lotion is applied to the affected areas, including the scalp 1 time per day. To apply the drug, the vial is brought to the affected area of the skin and somewhat compressed, after applying a few drops of lotion, it is easily rubbed into the skin until completely absorbed. The course of treatment with Elocom depends on the severity of the disease.
Side effects
With the local use of the drug in patients there were such side effects as burning, itching, skin rash and paresthesia. With prolonged use of the drug by Elocom, some patients had a development of skin atrophy. Very rarely, such effects as exacerbation of skin diseases, furunculosis, erythema, and nausea occurred. The manifestation of side effects characteristic of all topical glucocorticosteroids, including dry skin, hypertrichosis, reduction in the number of skin pigments, secondary infections and stretch marks, is also possible. With prolonged use, especially in patients under the age of 18, systemic side effects may develop, including suppression of the production of hormones by the adrenal cortex. If any side effects occur, the use of the drug should be discontinued and a doctor will be consulted.
Overdose
Symptoms: suppression of the hypothalamic-pituitary-adrenal system, including secondary adrenal insufficiency. Treatment: symptomatic, if necessary - correction of electrolyte imbalance, drug withdrawal (with long-term therapy - gradual cancellation).
Interaction with other drugs
Relevant data is not available.
special instructions
When applied to large areas of the skin for a long time, especially when applying occlusive dressings, the development of systemic action of the SCS is possible. Given this, patients should be observed in relation to signs of suppression of the function of the hypothalamic-pituitary-adrenal system and the development of Cushing's syndrome. Elocom Lotion should not be allowed to contact the eyes. Propylene glycol, which is part of the drug, can cause irritation at the site of application, and isopropanol - a burning sensation when it comes sore skin. In such cases, you should stop using Elocom Lotion and prescribe the appropriate treatment. It should be borne in mind that GCS can alter the manifestations of certain skin diseases, which can make the diagnosis difficult. In addition, the use of corticosteroids may cause delayed wound healing. In case of long-term cure of corticosteroids, a sudden cessation of therapy can lead to the development of rebound syndrome, manifested in the form of dermatitis with intense reddening of the skin and burning sensation.Therefore, after a long course of treatment, the drug should be discontinued gradually, for example, switching to an intermittent treatment before it is completely stopped. Use in pediatrics The safety and effectiveness of mometasone furoate when used topically in children for a period longer than 6 weeks has not been studied. about the safety and efficacy of use in children under 2 years of age are limited. Due to the fact that in children the value of the ratio of surface area and body weight is greater than in adults, children dverzheny greater risk of suppression of the hypothalamic-pituitary-adrenal system and the development of Cushing's syndrome in the application of any of the local deystviya.Dlitelnoe GCS GCS treatment of children can lead to violations of their growth and razvitiya.Deti should receive the minimum dose sufficient to achieve the effect.