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Active ingredients
Thiamine + Escin
Release form
Solution
Composition
100 g of solution contain: dry extract of horse chestnut seeds (5-7: 1) 4.725 g; thiamine hydrochloride 500 mg
Pharmacological effect
The drug used in violation of the venous circulation. Contains horse chestnut fruit extract, anti-exudative, venotonic effect. It has been established that an extract of horse chestnut fruit reduces the concentration of lysosomal enzymes, as a result of which the breakdown of mucopolysaccharides in the region of the capillary walls is reduced. Eskuzan reduces the permeability of blood vessels, preventing the filtration of low molecular weight proteins, electrolytes and water into the extracellular space. In randomized double-blind and cross-sectional studies, there was a decrease in transcapillary filtration and a significant decrease in edema, a decrease in the feeling of heaviness, fatigue, tension, itching, and pain.
Pharmacokinetics
Absorption and distribution After ingestion of 50 mg of horse chestnut fruit extract Cmax in blood plasma is reached in 2.35 hours and amounts to 25.31 ng / ml. Binding to plasma proteins is 84%. After ingestion, T1 / 2 is 19.87 hours. After ingestion, 0.11% of horse chestnut fruit extract excreted by the kidneys as escin.
Indications
Chronic venous insufficiency of varicose and post-thrombotic genesis and its complications, including diseases associated with functional impairment of blood supply: edema, convulsions in the calf muscles; pain and feeling of heaviness in the legs; phlebeurysm; hemorrhoids.
Contraindications
Hypersensitivity to the drug.
Precautionary measures
The drug should be taken before meals with a small amount of liquid.
Use during pregnancy and lactation
There are clinical data on the use of Eskuzana during pregnancy in patients with varicose veins and peripheral venous edema. Eskuzan should be used with caution during lactation, because The product contains ethanol.
Dosage and administration
Assign inside 12-15 drops 3 times / day. Before taking the drug the contents of the vial should be shaken.
Side effects
Rarely: rarely - irritation of the gastrointestinal mucosa.
Overdose
To date, cases of drug overdose Eskuzan were reported.
Interaction with other drugs
The action of thiamine, which is part of the drug Eskuzan, decreases with simultaneous use with sulfite-containing infusion solutions.
special instructions
The drug contains 31% by volume of ethanol. During long-term storage, the solution may cloud and precipitate out, which does not affect the effectiveness of the preparation.