Hepatrombin gel for external use (300 ME + 2.5 mg + 2.5 mg) g 40 g
Condition: New product
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Active ingredients
Allantoin + Heparin Sodium + Dexpanthenol
Release form
Gel
Composition
100 g of gel contains: sodium heparin 30,000 IU; Allantoin 250 mg; dexpanthenol 250 mg. Excipients: carbomer - 933 mg, levomenthol - 20 mg, disodium edetate - 100 mg, trolamine - 550 mg, mountain pine needle oil - 80 mg, pine pine needle oil - 80 mg, lemon oil - 20 mg, sorbitol - 2 g , isopropanol - 25.37 g, softigen 767 (macrogol-6-glyceryl-caprylocaprate) - 200 mg, polysorbate - 500 mg, purified water - 68.485 ml.
Pharmacological effect
Combined drug with antithrombotic, anti-inflammatory and improves the regeneration of tissues for external use. Heparin is a direct anticoagulant. When applied topically, heparin prevents the formation of blood clots, has a decongestant and anti-inflammatory effect, improves local blood flow. Allantoin has an anti-inflammatory effect, stimulates metabolic processes in tissues and promotes cell proliferation. Dexpanthenol improves absorption of heparin, stimulates granulation and epithelialization.
Pharmacokinetics
After topical application to the skin, heparin penetrates the epidermis relatively quickly and accumulates in the upper layers of the skin. Actively bound to skin proteins. It is slowly released from tissues with a period of excretion of about 1 h. It has a pharmacological effect at a concentration of 10 ME / ml in the epidermis and 0.6 ME / ml, respectively, in the skin.
Indications
Thrombosis; thrombophlebitis; phlebeurysm; trophic ulcers of the leg (for ointment); sports injuries; tendovaginitis; inflammatory infiltrates.
Contraindications
Infected skin lesions; violation of the integrity of the skin (for the gel); hypersensitivity to the drug.
Use during pregnancy and lactation
Application during pregnancy and lactation (breastfeeding) Hepatrombin with a heparin content of sodium 300 U / 1 g is possible in cases where the expected benefit of therapy for the mother outweighs the potential risk to the fetus or infant.
Dosage and administration
The gel is applied to the skin with a thin layer, rubbing it with light massaging movements from the bottom up. If the gel is used for thrombosis and thrombophlebitis, spreading is not recommended.
Side effects
Allergic reactions: skin rash, skin flushing, urticaria, angioedema.
Overdose
Data on drug overdose Gepatrombin not provided.
Interaction with other drugs
Data on drug interactions of the drug Gepatrombin not provided.
special instructions
The essential oils included in the composition of other ingredients of the gel have antimicrobial and analgesic effects.