Legalon 140 capsules 60 pcs
Condition: New product
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Active ingredients
Milk thistle fruit extract
Release form
Capsules
Composition
Dry extract of thistle fruit, polysorbate 80, povidone, mannitol, sodium carboxymethyl starch (type A), magnesium stearate. The composition of the capsule shell: gelatin, iron dye red oxide (E172), titanium dioxide (E171), sodium lauryl sulfate, black dye oxide (E172).
Pharmacological effect
It interacts with free radicals in the liver and converts them into less toxic compounds, interrupting the process of lipid peroxidation, prevents the destruction of cellular structures. In damaged hepatocytes, it stimulates the synthesis of structural and functional proteins and phospholipids (due to specific stimulation of RNA polymerase A), stabilizes cell membranes, prevents the loss of cell components (transaminases), and accelerates the regeneration of liver cells. It inhibits the penetration of certain hepatotoxic substances into the cell.
Pharmacokinetics
The absorption is low and slow (the period of semi-absorption is 2.2 h), it is metabolized in the liver by conjugation, T1 / 2 - 6 h. It is excreted mainly with bile in the form of glucuronides and sulfates. Does not accumulate in the body. There is an enterohepatic circulation.
Indications
- toxic liver damage (alcoholism; intoxication with halogen-containing hydrocarbons, heavy metal compounds; medicinal lesions of the liver) and their prevention.
Contraindications
- hypersensitivity to the drug.
Precautionary measures
Keep out of the reach of children.
Use during pregnancy and lactation
It is not recommended to use the drug during pregnancy and breastfeeding.
Dosage and administration
Inside, after eating, with a small amount of water. 1 capsule 3 times / day. Maintenance dose - 1 capsule 2 times / day.
Side effects
Allergic reactions, rarely - laxative effect.
Interaction with other drugs
Not described.