Miramistin solution for local use 0.01% 50ml
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Active ingredients
Miramistin
Release form
Solution
Composition
Benzyldimethyl [3- (myristoylamino) propyl] ammonium chloride monohydrate per 1 l-100 mg
Pharmacological effect
Miramistin; possesses a wide spectrum of antimicrobial action, including hospital strains resistant to antibiotics .; The drug has a pronounced bactericidal action against gram-positive (Staphylococcus spp., Streptococcus spp., Streptococcus pneumoniae, etc.), Gram-negative (Pseudomonas aeruginosa, Escherichia coli, Klebsiella spp. And others), aerobic and anaerobic and anaerobics. microbial associations, including nosocomial strains with multi-resistance to antibiotics .; Has antifungal activity on Aspergillus genus Ascomycetes and the genus Penicillium, the yeast (Rhodotorula rubra, Torulopsis gabrata etc.), and yeast-like fungi (Candida albicans, Candida tropicalis, Candida krusei, Pityrosporum orbiculare (Malassezia furfur), etc.) dermatophytes (Trichophyton rubrum, Trichophyton mentagrophytes, Trichophyton verrucosum, Trichophyton schoenleini, Trichophyton violacent, Epidermophyton Kaufman-Wolf, Epidermophyton floccosum, Microsporum gypseum, Microsporum canis, etc.), in the same time, in the case, however, in the need for a non-secured, non-secured, non-profit, etc., you can also use a new, non-secured, non-secured, full-sized, non-secured, etc. , including fungal microflora with resistance to chemotherapeutic drugs .; It has antiviral effect, is active against complex viruses (herpes viruses, human immunodeficiency virus and others) .; Miramistin; acts on sexually transmitted pathogens (Chlamydia spp., Treponema spp., Trichomonas vaginalis, Neisseria gonorrhoeae and others) .; Effectively prevents infection of wounds and burns. Activates regeneration processes. Stimulates protective reactions at the site of use, due to the activation of the absorption and digestive functions of phagocytes, potentiates the activity of the monocyte-macrophage system. It has a pronounced hyperosmolar activity, as a result of which it suppresses wound and perifocal inflammation, absorbs purulent exudate, contributing to the formation of a dry scab. Does not damage granulations and viable skin cells, does not inhibit marginal epithelialization .; It does not have a local irritant and allergenic properties.
Pharmacokinetics
When applied topically, the drug does not have the ability to be absorbed through the skin and mucous membranes.
Indications
For use in otorhinolaryngology: - complex treatment of acute and chronic otitis, sinusitis, tonsillitis, laryngitis, pharyngitis; - complex treatment of acute pharyngitis and / or exacerbation of chronic tonsillitis in children aged 3 to 14 years .; For use in dentistry: - Treatment and prevention of infectious and inflammatory diseases of the oral cavity: stomatitis, gingivitis, periodontitis, periodontitis; - hygienic processing of removable dentures .; For use in surgery,traumatology: - prevention of suppuration and treatment of purulent wounds; - treatment of purulent-inflammatory processes of the musculoskeletal system .; For use in obstetrics and gynecology: - prevention and treatment of suppurations of postpartum injuries, wounds of the perineum and vagina, postpartum infections; - prevention and treatment of inflammatory diseases (vulvovaginitis, endometritis) .; For use in combustiology: - treatment of superficial and deep burns of the II and IIIA degree; - preparation of burn wounds for dermatoplasty .; For use in dermatology, venereology: - treatment and prevention of pyoderma and dermatomycosis, candidiasis of the skin and mucous membranes, foot mycoses; - individual prevention of sexually transmitted diseases (syphilis, gonorrhea, chlamydia, trichomoniasis, genital herpes, genital candidiasis, etc.) .; For use in urology: - complex treatment of acute and chronic urethritis and urethroprostatitis specific (chlamydia, trichomoniasis, gonorrhea) and non-specific nature.
Contraindications
Individual intolerance to the drug.
Use during pregnancy and lactation
It is used in obstetrics for indications .; Data on the safety of the drug during lactation (breastfeeding) are not provided.
Dosage and administration
When purulent sinusitis - during puncture, the maxillary sinus is washed with a sufficient amount of the drug .; Tonsillitis, pharyngitis and laryngitis are treated by rinsing the throat and / or irrigation with a spray nozzle 3-4 times 3-4 times / day. The amount of the drug in 1 rinse 10-15 ml .; For stomatitis, gingivitis, periodontitis, a mouth rinse of 10-15 ml of the preparation is recommended 3-4 times / day; When used in surgery, traumatology, combustiology with the preventive and therapeutic purpose irrigate the surface of wounds and burns, loosely tampon wounds and fistulous passages, fix gauze tampons moistened with the preparation. The treatment procedure is repeated 2-3 times / day for 3-5 days. The method of active drainage of wounds and cavities with a daily flow rate of up to 1 l of the drug is highly effective; When used in obstetrics, gynecology for the prevention of postpartum infection, it is used in the form of vaginal irrigation before delivery (5-7 days), at birth after each vaginal examination and in the postpartum period 50 ml of the drug in the form of a tampon with an exposure of 2 hours, for 5 days For the convenience of vaginal irrigation, the use of a gynecological attachment is recommended.The contents of the bottle using a gynecological attachment to enter into the vagina and irrigate .; During delivery of women by caesarean section, immediately before the operation, the vagina is treated, during the operation - the uterus and the incision in it, and in the postoperative period tampons moistened with the preparation are inserted into the vagina with an exposure of 2 hours for 7 days. Treatment of inflammatory diseases is carried out by a course for 2 weeks by the intravaginal administration of tampons with the drug, as well as by the method of medicinal electrophoresis .; For the prevention of sexually transmitted diseases, the drug is effective if it is used no later than 2 hours after sexual intercourse. The contents of the vial using urological applicator enter into the urethra for 2-3 minutes: men (2-3 ml), women (1-2 ml) and into the vagina (5-10 ml). For convenience, the use of gynecological attachments is recommended. Treat the skin of the inner thighs, pubis, genitals. After the procedure it is recommended not to urinate for 2 hours; In the complex treatment of urethritis and urethroprostatitis, 2-3 ml of the drug are injected into the urethra 1-2 times / day, the course of treatment is 10 days .; For acute pharyngitis and / or acute exacerbation of chronic tonsillitis, the pharynx is irrigated with a spray nozzle. Children aged 3-6 years: single pressing on the head of the spray nozzle (3-5 ml per irrigation), 3-4 times / day; children aged 7-14 years old by pressing twice (5-7 ml per irrigation), 3-4 times / day; children older than 14 years of age 3-4 times pressing (10-15 ml per irrigation), 3-4 times / day. The duration of therapy ranges from 4 to 10 days, depending on the timing of remission .; Terms of use of the drug; The drug is ready for use .; Instructions on the use of packaging with a spray nozzle; 1. Remove the cap from the vial, and also remove the urological applicator from the 50 ml vial .; 2. Remove the attached spray nozzle from the protective packaging .; 3. Attach the spray nozzle to the bottle .; 4. Activate the spray nozzle by repeatedly pressing .; Instructions for using a 50 ml or 100 ml package with a gynecological attachment; 1. Remove cap from vial .; 2. Remove the enclosed gynecological attachment from the protective packaging .; 3. Attach the gynecological attachment to the vial without removing the urological applicator.
Side effects
Local reactions: in some cases, a sensation of light burning may occur at the site of application, which passes on its own, after 15-20 seconds, and does not require discontinuation of the drug. Allergic reactions.
Overdose
Data on drug overdose Miramistin; not.
Interaction with other drugs
With simultaneous use with antibiotics, their antibacterial and antifungal properties increased.