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Active ingredients
Ketoconazole
Release form
Ampoules
Composition
Active substance (per 1 g of shampoo): ketoconazole, 20 mg. Adjuvants (per 1 g of shampoo): sodium lauryl sulfate 380 mg, disodium lauryl sulfosuccinate 150 mg, diethanolamide of coconut oil fatty acids 20 mg, collagen hydrolyzate 10 mg, macroglide methyldextrose mg, sodium chloride 5 mg, hydrochloric acid 4 mg, imido urea 2 mg, flavoring 2 mg, sodium hydroxide 1 mg, dye red charming (E 129) 30 μg, water up to 1 g
Pharmacological effect
Ketoconazole, a synthetic imidazole-dioxolane derivative, has antifungal effects against dermatophytes such as Trichophyton spp., Epidermophyton spp., Microsporum spp., And yeast, such as Candida spp. and Malassezia spp. (Pityrosporum spp.). Nizoral shampoo 2% quickly reduces flaking and itching, which usually accompany seborrheic dermatitis, dandruff, scaby.
Pharmacokinetics
Concentrations of ketoconazole are not determined in the blood plasma after the local application of Nizoral shampoo 2% on the hairy part of the scalp, but are determined after the local application of the shampoo on the whole body at a concentration of 11.2 ng / ml - 33.3 ng / ml. It is unlikely that such concentrations can cause any drug interactions, however, increased allergic reactions are possible.
Indications
Treatment and prevention of infections caused by the yeast Malassezia spp. (Pityrosporum spp.), Such as pityriasis versicolor (local), seborrheic dermatitis and dandruff.
Contraindications
Hypersensitivity to any of the components of the shampoo.
Use during pregnancy and lactation
Since, when topically applied, ketoconazole is practically not absorbed, the use of Nizoral 2% shampoo during pregnancy and lactation is not contraindicated.
Dosage and administration
Children from infancy, adolescents and adults. Apply NIZORAL shampoo 2% for 3-5 minutes for the affected areas. Then rinse with water. Treatment: - Chicken versicolor: once a day for 5 days; - Seborrheic dermatitis and dandruff: twice per week for 2-4 weeks. Prevention: - Chicken lichen: once a day for 3 days (one-time course of treatment before the onset of summer). - seborrheic dermatitis and dandruff: weekly or 1 time in two weeks. Features of use in children is not available.
Side effects
Shampoo Nizoral 2% is usually well tolerated. As with other shampoos, local irritation, itching, or contact dermatitis (due to irritation or an allergic reaction) may occur. Hair may become oily or dry. However, when using Nizoral shampoo 2%, such phenomena are rarely observed. In some cases, mainly in patients with chemically damaged or gray hair, there was a change in hair color.
Overdose
When using shampoo Nizoral 2% of the development of an overdose is not expected, since the drug is intended only for external use. In case of accidental ingestion, special measures are not required. To prevent aspiration, it is forbidden to induce vomiting or use gastric lavage.
special instructions
When using shampoo, avoid contact with eyes. If shampoo gets into your eyes, rinse them with water. To prevent withdrawal with long-term topical treatment with corticosteroids, it is recommended to continue topical use of corticosteroids in combination with Nizoral 2% shampoo, followed by gradual withdrawal of corticosteroids for 2-3 weeks. Seborrheic dermatitis and dandruff are often accompanied by increased hair loss. In rare cases, enhanced hair loss was observed with the use of shampoo Nizoral 2%.