Nurofen for children suspension for oral administration of orange 150 ml
Condition: New product
1000 Items
Rating:
Be the first to write a review!
More info
Active ingredients
Ibuprofen
Release form
Suspension
Composition
Active ingredient: Ibuprofen Concentration of active ingredient (mg): 100 mg
Pharmacological effect
NSAIDs. It has analgesic, antipyretic and anti-inflammatory effects. The mechanism of action of ibuprofen, a derivative of propionic acid, is due to inhibition of the synthesis of prostaglandins - mediators of pain, inflammation and hyperthermic reaction. Indiscriminately blocks COX-1 and COX-2, thereby inhibiting the synthesis of prostaglandins. In addition, ibuprofen reversibly inhibits platelet aggregation. The analgesic effect is most pronounced for inflammatory pain. The effect of the drug lasts up to 8 hours.
Pharmacokinetics
Absorption and distribution Absorption - high, quickly and almost completely absorbed from the digestive tract. After taking the drug on an empty stomach in adults, ibuprofen is detected in the blood plasma after 15 minutes, C max of ibuprofen in the blood plasma is reached after 60 minutes. Taking the drug with food can increase the time to reach Cmax up to 1-2 hours. Binding to plasma proteins is 90%. Slowly penetrates into the joint cavity, lingers in the synovial fluid, creating greater concentrations in it than in the blood plasma. In limited studies, ibuprofen was found in breast milk at very low concentrations. Metabolism and excretion After absorption, about 60% of the pharmacologically inactive R-form slowly transforms into active S-form. It is metabolized in the liver. It is excreted by the kidneys (in unchanged form - no more than 1%) and, to a lesser extent, with bile. T1 / 2 - 2 h.
Indications
Nurofen for children is used from 3 months of life up to 12 years as an antipyretic in case of acute respiratory diseases, flu, childhood infections, post-vaccination reactions and other infectious and inflammatory diseases accompanied by fever. The drug is used as an anesthetic for pain syndrome of weak or moderate intensity, including: headache, toothache, migraine, neuralgia, pain in the ears and in the throat, pain during sprains and other types of pain. The doctor may also recommend this drug for other indications (in this case, follow the recommendations of the doctor on the dosage and pattern of administration).
Contraindications
Nurofen for children should not be used for: hypersensitivity to ibuprofen, acetylsalicylic acid or other NSAIDs, as well as to other components of the drug; bronchial asthma, urticaria, rhinitis, triggered by the use of acetylsalicylic acid (salicylates) or other NSAIDs; if the child has ulcerative lesions of the gastrointestinal tract; active gastrointestinal bleeding with inflammatory bowel disease; with confirmed hypokalemia; blood diseases: hypocoagulation, leukopenia, hemophilia; renal and / or liver failure; hearing loss
Precautionary measures
Do not exceed the recommended dose. With caution, you should prescribe the drug while using other NSAIDs; history of a single episode of gastric ulcer or gastric ulcer bleeding, gastritis, enteritis, colitis, Helicobacter pylori infection, ulcerative colitis; bronchial asthma or allergic diseases in the acute stage or in the anamnesis (the development of bronchospasm is possible); severe somatic diseases; systemic lupus erythematosus or mixed connective tissue disease (Sharpe syndrome) - an increased risk of aseptic meningitis; renal failure, incl. with dehydration (CC 30-60 ml / min), fluid retention and edema; liver failure; hypertension and / or heart failure; cerebrovascular diseases; dyslipidemia / hyperlipidemia; diabetes; peripheral artery diseases; blood diseases of unknown etiology (leukopenia, anemia); simultaneous use of other drugs that may increase the risk of ulcers or bleeding, in particular, GCS for oral administration (including prednisolone), anticoagulants (including warfarin), selective serotonin reuptake inhibitors (including including citalopram, fluoxetine, paroxetine, sertraline) or antiplatelet agents (including acetylsalicylic acid, clopidogrel); in the I and II trimester of pregnancy, in the period of breastfeeding, elderly patients.
Use during pregnancy and lactation
Use of the drug in the III trimester of pregnancy is contraindicated. Before using the drug in the I and II trimesters of pregnancy or during breastfeeding should consult a doctor. There is evidence that small amounts of ibuprofen can penetrate into breast milk without any negative consequences for the health of the infant.
Dosage and administration
Nurofen for children - a drug specifically designed for children. Carefully read the instructions before using the drug. The drug is taken orally. Shake the bottle thoroughly before use. A convenient measuring syringe is attached to accurately measure the dose of the drug. 5 ml of the preparation contain 100 mg of ibuprofen.
Side effects
When using the drug Side effects are rarely observed, however, the following side effects may occur: from the gastrointestinal tract: nausea, vomiting, discomfort, or epigastric pain, laxative effect, possible erosive-ulcerative lesions, bleeding. allergic reactions: skin rash, pruritus, urticaria, exacerbation of bronchial asthma, angioedema, anaphylactoid reactions, anaphylactic shock, bronchospasm, fever, erythema multiforme (including Stevens-Johnson syndrome), toxic epidermus, anxiety epidermus, erythema syndrome (including Stevens-Johnson syndrome), toxic epidermus, anxiety disorders, erythema Systems: headache, dizziness, psychomotor agitation, insomnia, cardiovascular system: tachycardia, increased blood pressure. on the part of the blood-forming organs: anemia, thrombocytopenia, agranulocytosis, leukopenia. on the part of the urinary system: renal dysfunction, cystitis. If these or other side effects appear, you should stop using the drug and consult a doctor.
Overdose
In children, overdose symptoms may occur after taking a dose in excess of 400 mg / kg body weight. In adults, the dose-dependent effect of overdose is less pronounced. T1 / 2 of the drug in overdose is 1.5-3 hours. Symptoms: nausea, vomiting, pain in the epigastric region or, rarely, diarrhea, tinnitus, headache and gastrointestinal bleeding. In more severe cases, there are manifestations of the central nervous system: drowsiness, rarely - excitement, convulsions, disorientation, coma. In cases of severe poisoning, metabolic acidosis and an increase in prothrombin time, renal failure, liver tissue damage, decreased blood pressure, respiratory depression and cyanosis can develop. Patients with bronchial asthma may have an exacerbation of this disease. Treatment: symptomatic, with mandatory airway management, monitoring of ECG and basic vital signs until the patient's condition is normalized.Oral administration of activated charcoal or gastric lavage for 1 hour after administration of a potentially toxic dose of ibuprofen is recommended. If ibuprofen has already been absorbed, an alkaline drink may be given to remove the acidic ibuprofen derivative by the kidneys, forced diuresis. Frequent or prolonged seizures should be stopped in / in the introduction of diazepam or lorazepam. With the worsening of bronchial asthma, the use of bronchodilators is recommended.
Interaction with other drugs
The simultaneous use of ibuprofen with the drugs listed below should be avoided. Acetylsalicylic acid: with the exception of acetylsalicylic acid in low doses (not more than 75 mg / day) prescribed by a doctor, because the combined use may increase the risk of side effects. With simultaneous use of ibuprofen reduces the anti-inflammatory and antiplatelet effect of acetylsalicylic acid (it is possible to increase the incidence of acute coronary insufficiency in patients who receive acetylsalicylic acid in small doses as an antiplatelet agent after starting ibuprofen). Other NSAIDs, including selective COX-2 inhibitors : the simultaneous use of two or more drugs from the group of NSAIDs should be avoided due to the possible increase in the risk of side effects. use simultaneously with the following drugs. Anti-coagulants and thrombolytic drugs: NSAIDs can enhance the effect of anticoagulants, in particular, warfarin and thrombolytic drugs. Antihypertensives (ACE inhibitors and angiotensin II receptor antagonists) and diuretics can be used as an example. Diuretics and ACE inhibitors can increase the nephrotoxicity of NPVS.GKS: an increased risk of gastrointestinal ulcers and gastrointestinal bleeding. Antiaggregants and selective serotonin reuptake inhibitors: an increased risk of gastrointestinal bleeding. worsening heart failuredecrease in glomerular filtration rate and an increase in the concentration of cardiac glycosides in the blood plasma. Lithium preparations: there is evidence of the likelihood of increasing the concentration of lithium in the blood plasma during the use of NPVS. increased risk of nephrotoxicity with the simultaneous appointment of NSAIDs and cyclosporine. Mifepristone: NSAID administration should be started no earlier than 8-12 days after taking mifepristone, lku NSAIDs may reduce the effectiveness of mifepristona.Takrolimus: while the appointment of NSAIDs and tacrolimus may increase the risk nefrotoksichnosti.Zidovudin: the simultaneous use of NSAIDs and zidovudine may increase gematotoksichnosti. There is evidence of an increased risk of hemarthrosis and hematomas in HIV-positive patients with hemophilia who received joint treatment with zidovudine and ibuprofen. Quinolone antibiotics: patients who receive joint treatment of NSAIDs and quinolone antibiotics may increase the risk of seizures.
special instructions
It is recommended to take the drug as short a course as possible and at the minimum effective dose necessary to eliminate the symptoms. During long-term treatment, monitoring of the peripheral blood pattern and the functional state of the liver and kidneys is necessary. When symptoms of gastropathy appear, close monitoring is shown, including esophagogastroduodenoscopy, complete blood count ( hemoglobin determination), stool test for occult blood. If it is necessary to determine 17-ketosteroids, the drug should be canceled 48 hours before ssledovaniya.V treatment period is not suitable for receiving etanola.Preparat contraindicated in patients with fructose intolerance, since contains maltitol. Nurofen for children can be used for children with diabetes, because the drug does not contain sugar. It does not contain dyes. Patients with renal insufficiency should be consulted with a doctor before using the drug, because there is a risk of deterioration of the functional state of the kidneys. Patients with arterial hypertension, including.history and / or chronic heart failure, you should consult with your doctor before using the drug, because the drug can cause fluid retention, increased blood pressure and edema. Ibuprofen, you should avoid driving vehicles or driving mechanisms.