Phlebodia 600 coated pills 600mg N15
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Active ingredients
Diosmin
Release form
Pills
Composition
Active ingredient: Diosmin (Diosmin) Active ingredient concentration (mg): 600
Pharmacological effect
The drug has a phlebotonizing effect (reduces vein distensibility, increases venous tone (dose-dependent effect), reduces venous congestion), improves lymphatic drainage (increases the tone and frequency of lymph capillary contractions, increases their functional density, decreases lymphatic pressure), improves microcirculation (increases capillary resistance (dose-dependent effect), reduces their permeability), reduces the adhesion of leukocytes to the venous wall and their migration into para-venous tissues, improves oxygen diffusion and perfusion in skin tissue, has anti-inflammatory action. enhances the vasoconstrictor action of adrenaline, norepinelia, blocks the production of free radicals, the synthesis of prostaglandins and thromboxane.
Pharmacokinetics
Quickly absorbed from the gastrointestinal tract, detected in the plasma after 2 h after administration. Cmax in plasma is reached 5 h after administration. It is evenly distributed and accumulated in all layers of the wall of the hollow veins and subcutaneous veins of the lower extremities, to a lesser extent in the kidneys, liver and lungs and other tissues. The selective accumulation of diosmin and / or its metabolites in the venous vessels reaches its maximum by 9 o'clock after administration and remains within 96 hours. Excreted by the kidneys - 79%, by the intestines - 11%, with bile - 2.4%.
Indications
As part of complex therapy: - to eliminate the symptoms of lymphovenous insufficiency of the lower extremities: feeling of heaviness or fatigue in the legs, pain; - additional treatment in violation of microcirculation; - symptomatic therapy of acute hemorrhoids.
Contraindications
Hypersensitivity to the components of the drug, breastfeeding period, children under 18 years of age, pregnancy (I term) (experience with use is limited).
Precautionary measures
Store at a temperature not higher than 30 ° C. Keep out of the reach of children.
Use during pregnancy and lactation
Until now, in clinical practice, there have been no reports of any side effects when using the drug in pregnant women. Use during pregnancy in the II and III trimesters is possible only by prescription of the doctor in cases where the expected benefit to the mother outweighs the potential risk to the fetus. In experimental studies, no teratogenic effects on the fetus have been identified.During breastfeeding is not recommended taking the drug, because no data on the penetration of the drug into breast milk.
Dosage and administration
Before using the drug should consult a doctor. The drug is intended for oral administration. With varicose veins of the lower extremities and chronic lymphatic insufficiency (edema, pain, convulsions) prescribed on I tablet a day in the morning on an empty stomach. The duration of therapy is usually 2 months. With exacerbation of hemorrhoids, the drug is prescribed 2-3 pills per day with meals for 7 days. If you miss one or more doses of the drug, you must continue to use the drug in the usual way and in the usual dose.
Side effects
In rare cases, hypersensitivity to the components of the drug, requiring a break in treatment: from the gastrointestinal tract - dyspeicia disorders (heartburn, nausea, abdominal pain), from the central nervous system - headache. If any of the side effects indicated in the instruction are aggravated, or you have noticed any other side effects that are not indicated in the instruction, inform your doctor.
Overdose
Symptoms of overdose are not described.
Interaction with other drugs
Clinically significant effects of interaction with other drugs are not described.
special instructions
Treatment of an acute attack of hemorrhoids is carried out in combination with other drugs, in the absence of a rapid clinical effect, it is necessary to conduct additional examinations and adjust the therapy being conducted. Effect on the ability to drive vehicles and control mechanisms