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Active ingredients
Metamizole sodium + Pitofenon + Fenpiverinium bromide
Release form
Pills
Composition
1 tablet contains: Active ingredient: Metamizol 500 mg, Pitofenone hydrochloride 5 mg, Fenpiverinium bromide 100 mcg; Excipients: starch, lactose, microcrystalline cellulose, colloidal silicon dioxide, magnesium stearate, talc., 20 pcs. - strips (5) - packs cardboard.
Pharmacological effect
Spasmoangetic. The drug contains non-narcotic analgesic metamizole sodium (analgin), myotropic antispasmodic pitofenone hydrochloride and anticholinergic drug fenpiverinium bromide. Metamizole is a pyrazolone derivative. It has analgesic, antipyretic and anti-inflammatory effects. Pitofenon, like papaverine, has a direct myotropic effect on the smooth muscles of the internal organs and causes its relaxation.; Fenpiverine, due to the holinoblocking effect, has an additional relaxing effect on smooth muscles.; The combination of the three components of the drug leads to a joint enhancing their pharmacological action, expressed in the relief of pain, relaxation of smooth muscles, and a decrease in elevated body temperature.
Indications
- mild or moderate pain syndrome in spasms of smooth muscles of internal organs - renal and biliary colic, intestinal spasms, dysmenorrhea and other spastic states of internal organs; - for short-term symptomatic treatment for headaches, migraine pain, joint pain, neuralgia, sciatica, myalgia; - as an adjuvant can be used to reduce pain after surgical and diagnostic interventions; - to reduce fever in colds and infectious and inflammatory diseases.
Contraindications
- pronounced violations of the liver or kidneys; - genetic absence of glucose-6-phosphate dehydrogenase; - tachyarrhythmia; - angle-closure glaucoma; - prostatic hypertrophy with a tendency to urinary retention; - gastrointestinal obstruction; - megacolon; - diseases of the blood system; - collaptoid states; - I term and the last 6 weeks of pregnancy; - lactation period; - hypersensitivity to pyrazolone derivatives and other components of the drug.; Tablets do not apply to children under 5 years of age.
Use during pregnancy and lactation
Contraindications: I trimester and the last 6 weeks of pregnancy; lactation period.
Dosage and administration
Adults and adolescents over 15 years old are prescribed orally (preferably after meals), 1-2 pills 2-3 times / day. The daily dose should not exceed 6 tab. The duration of the reception is not more than 5 days.; The increase in the daily dose of the drug or the duration of treatment is possible only under medical supervision.; In children, the drug is used only as prescribed by a doctor. Dosage for children 6-8 years -1/2 pills; for children 9-12 years - 3/4 pills; for children 13-15 years old - 1 tablet; the multiplicity of appointments - 2-3 times / day; Other dosage regimens are possible only after consulting a doctor.
Side effects
In therapeutic doses, the drug is usually well tolerated.; Sometimes allergic reactions are possible (skin rash, itching, very rarely - anaphylactic shock) .; In rare cases, a burning sensation in the epigastric region, dry mouth, headache.; Dizziness, a decrease in blood pressure are possible. pressure, tachycardia, cyanosis.; With long-term use - cases of blood system disorders (thrombocytopenia, leukopenia, agranulocytosis) .; Achu.
Overdose
In case of drug overdose, the following symptoms may be observed: vomiting, feeling of dry mouth, change in sweating, disturbance of accommodation, hypotension, drowsiness, confusion, impaired liver and kidney function, convulsions; Treatment is symptomatic.
Interaction with other drugs
Simultaneous use of Revalgin with other non-narcotic analgesics may result in mutual enhancement of toxic effects. Tricyclic antidepressants, oral contraceptives, allopurinol violate Metamizole metabolism in the liver and increase its toxicity. ; Simultaneous use with cyclosporine reduces the level of the latter in the blood.; Sedatives and tranquilizers strengthen the painless ivayuschee action Revalgina;. If necessary, the simultaneous use of these and other drugs should consult a physician.
special instructions
With caution and under the supervision of a physician, the drug should be used by patients with impaired liver and / or kidney function,with a tendency to hypotonia, bronchospasm, as well as with increased individual sensitivity to NSAIDs or non-narcotic analgesics;