More info
Active ingredients
Caffeine + Paracetamol + Phenylephrine + Pheniramine
Release form
Pills
Composition
Paracetamol 500 mg, caffeine 30 mg, phenylephrine hydrochloride 10 mg, chlorphenamine maleate 2 mg. Auxiliary substances: colloidal silicon dioxide, corn starch, corn starch (for 20% of paste), povidone (K-30), methyl parahydroxybenzoate of magnesium, magnesium stearar, talc, sodium carboxymethyl starch (type A), a crimson dye (Ponso 4R).
Pharmacological effect
Combined drug. Paracetamol has an analgesic and antipyretic effect. Reduces pain observed in colds, sore throat, headache, muscle and joint pain, reduces high fever.Phenylephrine - alpha 1-adrenergic mimic. Has vasoconstrictor action, reduces edema and hyperemia of the mucous membranes of the upper respiratory tract and sinuses nosa.Hlorfenamin - blocker histamine H1-receptors, exerts an antiallergic effect, reduces edema and hyperemia of the mucous membranes of the nasal cavity, nasopharynx and sinuses, eliminating itchy eyes and nose, reduces exudative manifestations. Caffeine has a stimulating effect on the central nervous system, which reduces fatigue and drowsiness, increases mental and physical petitiveness.
Pharmacokinetics
Data on the pharmacokinetics of the drug Rinza; not provided.
Indications
- symptomatic treatment of colds, acute respiratory viral infections (including influenza), accompanied by fever, pain, rhinorrhea.
Contraindications
- pronounced atherosclerosis of the coronary arteries; - arterial hypertension (severe); - diabetes mellitus (severe); - simultaneous administration of tricyclic antidepressants, MAO inhibitors, beta-adrenergic blockers; - simultaneous administration of preparations containing Rinza preparation; components; - pregnancy; - lactation period; - children's age up to 15 years; - hypersensitivity to the drug components.
Precautionary measures
Do not exceed the recommended dose. With caution, you should use the drug for hypertension, hyperthyroidism, pheochromocytoma, diabetes, bronchial asthma, chronic obstructive pulmonary disease,deficiency of glucose-6-phosphate dehydrogenase, blood diseases, congenital hyperbilirubinemia (Gilbert syndrome, Dubin-Johnson syndrome, Rotor syndrome), hepatic and / or renal failure, angle-closure glaucoma, prostatic hyperplasia.
Use during pregnancy and lactation
The appointment of the drug Rinza is contraindicated; during pregnancy and lactation.
Dosage and administration
Adults and children over 15 are prescribed 1 tab. 3-4 times / day The maximum daily dose - 4 tab. The course of treatment is not more than 5 days.
Side effects
Allergic reactions: skin rash, pruritus, urticaria, angioedema. On the side of the CNS: dizziness, disturbed sleep, increased irritability. On the side of the cardiovascular system: increased blood pressure, tachycardia. On the part of the digestive system: dry mouth, nausea, vomiting, epigastric pain, hepatotoxic action. From the organ of vision: mydriasis, accommodation paresis, increased intraocular pressure. From the hematopoietic system: anemia, thrombocytopenia, agranulocytosis, hemolytic anemia, aplastic anemia, m ethemoglobinemia, pancytopenia. From the urinary system: renal colic, glycosuria, inertial nephritis, papillary necrosis. From the respiratory system: bronchial obstruction.
Overdose
Conditioned, as a rule, paracetamol, overdose manifests itself after taking more than 10-15 g of the latter. Symptoms: pale skin, anorexia, nausea, vomiting, hepatonecrosis, increased liver transaminase activity, increased prothrombin time. Treatment: gastric lavage followed by the appointment of activated carbon , symptomatic therapy, the introduction of methionine after 8-9 hours after overdose and acetylcysteine - after 12 hours.
Interaction with other drugs
Rinza; enhances the effects of MAO inhibitors, sedatives, ethanol. With simultaneous use of the drug Rinza; with antidepressants, anti-parkinsonian drugs, antipsychotics, phenothiazine derivatives, the risk of urinary retention, dry mouth, constipation increases. Concurrent use with Rinza; increase the risk of developing glaucoma. Paracetamol reduces the effectiveness of diuretic drugs. Ethanol enhances the sedative effect of antihistamine drugs. The use of chlorphenamine simultaneously with MAO inhibitors, furazolidone can lead to hypertensive crisis, arousal,hyperpyrexia.Tricyclic antidepressants increase the adrenomimetic effect of phenylephrine, the simultaneous appointment of halothane, increases the risk of developing ventricular disorders. other inducers of liver microsomal enzymes increase the risk of the development of the hepatotoxic effect of paracetamol.
special instructions
During the period of use of the drug Rinza; one should refrain from drinking alcohol, sleeping pills and anxiolytic drugs (tranquilizers). Do not take concurrently with other drugs containing paracetamol. water or the street. It is necessary to put the drug in the bag and put it in the trash. These measures will help to protect the environment. Impact on the ability to drive motor vehicles and control mechanisms. During the period of treatment, you should refrain from driving motor vehicles and engaging in other potentially hazardous activities that require increased concentration and psychomotor reactions.