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Active ingredients
Butamirate + Gvayfenezin
Release form
Pills
Composition
Guaifenesin 100 mg, butamirate dihydrocitrate 4 mg. Adjuvants: colloidal silicon dioxide - 1 mg, mannitol - 60 mg, microcrystalline cellulose - 60 mg, glyceryl tribehenate - 1 mg, magnesium stearate - 4 mg
Pharmacological effect
Combined drug that has mucolytic (expectorant) and antitussive effect. Butamirate dihydrocitrate has a peripheral local anesthetic effect on the sensitive nerve endings of the bronchial mucosa, which provides an antitussive effect. Gvayfenezin increases the secretion of bronchial glands and reduces the viscosity of mucus. The increase in secretion is due both to a direct effect on the bronchial glands — by stimulating secretion from the bronchial glands and removing acid glycoproteins from acinar cells, and by a reflex pathway, when the afferent parasympathetic fibers of the gastric mucosa are irritated and the respiratory center is inhibited. Increase the tone n. vagus stimulates the production of bronchial secretions. The mucus produced by the bronchial glands enhances the activity of the ciliary epithelium, and as a result, the evacuation of mucus from the bronchi and its coughing is facilitated.
Pharmacokinetics
Butamirata dihydrocitrate: When ingested butamirata dihydrocitrate quickly and completely absorbed from the gastrointestinal tract. Plasma protein binding is 94%. It is metabolized to form 2 metabolites, which also have antitussive action. T1 / 2 - 6 h. Metabolites are excreted mainly (90%) by the kidneys and only a small part through the intestines. Gvayfenezin: Gvayfenezin when taken orally is rapidly absorbed from the digestive tract. Plasma protein binding is negligible. Gvayfenezin is rapidly metabolized, with the formation of inactive metabolites, which are excreted by the kidneys. T1 / 2 - 1 h.
Indications
- dry irritating cough (including in infectious and inflammatory diseases of the upper and lower respiratory tract).
Contraindications
- myasthenia — children up to 12 years old — I trimester of pregnancy — lactation period (breastfeeding) —sensitivity to the components of the drug.
Dosage and administration
The drug is taken orally after meals.Tablets should be taken without chewing, with a liquid (water, tea, fruit juice).