Tempalgin 500mg N20 coated pills
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Active ingredients
Metamizole sodium + triacetonamine-4-toluenesulfonate
Release form
Pills
Composition
Film-coated pills, composition (1 tab.): Active substances: metamizole sodium monohydrate - 500 mg triacetonamine-4-toluenesulfonate - 20 mg adjuvants: wheat starch - 95 mg; MCC - 75 mg; Povidone K25 - 45 mg; talc - 15 mg; magnesium stearate - 10 mg-membrane film: Opadry II green 85 F 21526 - 23 mg: polyvinyl alcohol partially hydrolyzed - 9.2 mg; macrogol 3350 - 4.646 mg; talc - 3,404 mg; titanium dioxide (E171) - 4.37 mg; quinoline yellow (E104) aluminum varnish - 1.035 mg; brilliant blue (E133) FCF aluminum lacquer - 0.345 mg
Pharmacological effect
Pharmacokinetics
Indications
Tempalgin is a combination analgesic antipyretic agent. It has analgesic, antipyretic, mild anti-inflammatory and sedative effects. The drug contains non-opioid analgesic metamizol sodium and anxiolytic (tranquilizer) tempidone.
Contraindications
Inside, after eating, drinking water. The dose depends on the severity of pain and individual sensitivity to the drug. Adults: the usual dose - 1 tab. 1-3 times a day. The maximum single dose should not exceed 1 table. The maximum daily dose is 4 tab. During dental procedures: 1 tab. 30 minutes before the intervention. Children over 15 years old: 1 tab. in a day. The maximum daily dose - 2 tabl. Special groups of patientsPatients over 65 years. Usually, no dose reduction is required. In patients with age-related disorders of the kidneys and liver, Tempalgin treatment should be short. The maximum daily dose - 2 tab. Disruption of liver function. In patients with impaired liver function, an increase in T1 / 2 metabolites of metamizole sodium is possible. In patients with moderate or severe liver damage, treatment is recommended 1/2 of the recommended dose for adults (maximum daily dose - Table 2.) Renal dysfunction. Metamizole sodium and its metabolites are excreted by the kidneys. In patients with impaired renal function, treatment with Tempalgin should be carried out using ½ of the recommended dose for adults (maximum daily dose - 2 tabl.). Duration of treatmentTreatment with Tempalgin should not last more than 3–5 days. Its use over a longer period of time or at higher doses is possible only after consulting a doctor.
Use during pregnancy and lactation
Symptoms: nausea, vomiting, epigastric pain, oliguria, tachycardia, decreased blood pressure, shortness of breath, tinnitus, drowsiness, impaired consciousness, convulsions. Treatment: gastric lavage, the appointment of saline laxatives and activated carbon; in severe cases - hemodialysis, forced diuresis, symptomatic therapy, with the development of convulsive syndrome - in / in the introduction of diazepam and fast-acting barbiturates.
Dosage and administration
- Pain syndrome (headache, neuralgia, toothache, migraine, myalgia, algomenorrhea, arthralgia); - visceral pains (renal, intestinal, hepatic colic) to potentiate the effect of antispasmodics; - weak or moderate pain after diagnostic or surgical interventions.
Side effects
Precautionary measures
Overdose
Tempalgin enhances the effects of ethanol. Simultaneous use of Tempalgin with chlorpromazine or other phenothiazine derivatives may lead to the development of severe hyperthermia. Sedatives and tranquilizers increase the analgesic effect of the drug. When used simultaneously, tiamazole and cytostatics increase the risk of developing leukopenia. the latter in blood plasma. Metamizole sodium, displacing oral hypoglycemic drugs, indirect anticoagulants, GCS and indomethacin, increases their effect. With simultaneous use of barbiturates, phenylbutazone and other inducers of microsomal liver enzymes weaken the effect of metamizole sodium. Simultaneous use of metamizole sodium with other non-opioid analgesics, tricyclic anti-depressants, and also by using the same skin and eye tissue, tricyclic anti-depressants and other non-opioid analgesics, tricyclic antidepressants, and other non-opioid analgesics, tricyclic anti-depressants, and other anti-suppressant drugs. increased toxic effects. Codeine, histamine H 2 -receptor blockers and propranolol slow down the excretion of metamizole I and strengthen its action.
Interaction with other drugs
hypersensitivity to the components of the drug, severe renal / hepatic insufficiency, chronic heart failure, arterial hypotension (SBP below 100 mmHg), hematopoietic suppression (granulocytopenia, leukopenia, agranulocytosis, cytostatic or infectious neutropenia), glucose-6-deficiency, glucose-6-deficient. , "Aspirin" asthma, children's age (up to 14 years). With caution prescribed for kidney diseases (pyelonephritis, glomerulonephritis, includinghistory), hepatic / renal failure moderate severity, with bronchial asthma, susceptibility to the development of arterial hypotension, with prolonged alcohol abuse.
special instructions
burning sensation in epigastria, dry mouth, cholestasis, jaundice, increased transaminase, hyperbilirubinemia