Vincristine solution for intravenous injection vials of 2 ml
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Active ingredients
Vincristine
Release form
Solution
Composition
Vincristine sulfate 1 mg. Excipients: mannitol, sodium hydroxide, sulfuric acid, water d / and
Contraindications
Intrathecal administration of vincristine is prohibited. Vincristine is administered strictly in / in with an interval of 1 week. The duration of the injection should be approximately 1 minute. Before the introduction of the contents of the vial diluted in the attached solvent with the addition of the required amount of 0.9% sodium chloride solution to obtain a concentration of 0.1 mg / ml. When administering, care must be taken to avoid extravasation. The dose is selected individually. The average dose is for adults: 1.4 mg / m2 of body surface, a single dose should not exceed 2 mg. for children - 1.5-2 mg / m2 of body surface. For children weighing up to 10 kg, the initial dose should be 0.05 mg / kg per week. In patients with impaired liver function and plasma bilirubin concentration above 51.3 mcmol / L, a dose reduction of 50% is recommended.
Use during pregnancy and lactation
In case of accidental overdose, an increase in Vincristine side effects should be expected. The specific antidote is not known. Treatment is symptomatic and should include limiting fluid intake, prescribing diuretics (to prevent complications associated with the development of the syndrome of increased secretion of antidiuretic hormone), the use of phenobarbital (to prevent seizures), the use of laxatives (to prevent intestinal obstruction). It is also necessary to monitor the activity of the cardiovascular system and carry out hematological monitoring. Hemodialysis is not effective. In addition to the above, leukovorin can be given at a dose of 100 mg i.v. every 3 hours for 24 hours and then every 6 hours for at least 48 hours.
Dosage and administration
- acute leukemia - Hodgkin's and non-Hodgkin's lymphomas - Wilms' tumor - rhabdomyosarcoma - neuroblastoma - myeloma - Kaposi's sarcoma - bone and soft tissue sarcoma - small cell lung cancer - uterine choriocarcinoma - brain tumor. Vincristine is also used for idiopathic thrombocytopenic purpura (for resistance to corticosteroids and the ineffectiveness of splenectomy).
Side effects
Precautionary measures
special instructions
Precautionary measures