Vizin classic drop-eyed 0.05% ampoules0.05ml (odnokr.prim) N10
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Active ingredients
Tetrizolin
Release form
Ampoules
Composition
On 1 ml: tetrizolina hydrochloride 500 mcg. Excipients: boric acid - 12.3 mg, sodium tetraborate (borax) - 0.25 mg, sodium chloride - 2.23 mg, water d / and - up to 1 ml.
Pharmacological effect
Alpha adrenomimetic. Tetrizoline stimulates the α-adrenoreceptors of the sympathetic nervous system, does not have or has a weak effect on β-adrenoreceptors. Being an adrenomimetic amine, tetrizolin has a vasoconstrictive effect and reduces tissue swelling. The drug begins 60 seconds after instillation and lasts 4-8 hours.
Pharmacokinetics
When applied topically, systemic absorption is possible in patients with lesions of the mucous membrane and epithelium. Detailed pharmacokinetic studies have not been conducted with the use of eye drops.
Indications
To relieve swelling and hyperemia of the conjunctiva caused by chemical and physical factors (smoke, wind, dust, chlorinated water, light, cosmetics, contact lenses), as well as allergic reactions such as pollinosis.
Contraindications
- angle-closure glaucoma; - children's age up to 2 years; - hypersensitivity to the drug components.
Precautionary measures
The drug should be used with caution in patients with severe cardiovascular diseases (for example, ischemic heart disease, arterial hypertension), pheochromocytoma, prostate hyperplasia, hyperthyroidism, diabetes mellitus, porphyria, dry rhinitis, dry keratoconjunctivitis, glaucoma, and patients receiving inhibitors of rhinitis, dry keratoconjunctivitis, glaucoma, and patients receiving inhibitors of rhinitis, dry keratoconjunctivitis, glaucoma, and patients receiving inhibitors of rhinitis. other means that can increase blood pressure. The use of the drug in angle-closure glaucoma is contraindicated. For other types of glaucoma, the drug is used with extreme caution and under the supervision of a physician.
Use during pregnancy and lactation
Data on the penetration of the drug through the placenta and into breast milk are missing. Considering the possibility of developing systemic side effects, it is possible to use the drug during pregnancy and during breastfeeding only if, according to the doctor, the expected benefit to the mother outweighs the potential risk to the fetus and child.
Dosage and administration
Locally.Adults and children over 2 years old, 1 drop in the affected eye 2-3 times / day. The drug should be used for more than 4 days only under the supervision of a physician. Instructions for the use of ampoules for single use Each ampoule of Vizin Classic is intended for single use only. The drug should be used immediately after opening the ampoule. The amount of the drug in one ampoule is sufficient for a single injection into both eyes. It is necessary to break off 1 ampoule from the strip, and put the remaining ampoules back into the foil bag. Then open the ampoule, turning off the upper, unfilled part of the ampoule. To drip the drug in the conjunctival sac, slightly pressing on the filled part of the ampoule
Side effects
Infrequently: reactive hyperemia, burning sensation, dryness of the mucous membrane, systemic disturbances (for example, a sensation of heartbeat, headache, tremor, weakness, sweating, and an increase in blood pressure). Perhaps the appearance of blurred vision, irritation of the conjunctiva or rarely - mydriasis. In addition, systemic adrenomimetic effects are rarely observed. In some cases, after prolonged use of tetrizolin, keratinization of the epithelium (xerosis) of the conjunctiva with occlusion of the lacrimal punctures and epiphora has been reported.
Overdose
Symptoms Excessive systemic absorption of alpha-adrenomimetic imidazole derivatives can lead to the inhibition of CNS, which is manifested by drowsiness, low body temperature, bradycardia, shock-like hypotension, apnea and coma. , increased blood pressure, pulmonary edema, impaired respiratory function, mental disorders. The risk of overdose symptoms associated with the absorption of the drug is especially high in newborns and ma small children when swallowed drops, resulting in possible violations of the central nervous system, as well as respiratory depression and collapse. The toxic dose of tetrizolin is 0.01 mg / kg body weight. Treatment If any symptoms of overdose occur, you should immediately consult a doctor. stomach, oxygen inhalation, antipyretic and anticonvulsant drugs.To reduce blood pressure apply phentolamine 5 mg in saline solution slowly in / in or 100 mg orally. For patients with low blood pressure, vasopressor agents are contraindicated. In the event of symptoms caused by the blockade of m-cholinergic receptors, apply the antidote physostigmine.
Interaction with other drugs
The drug Vizin Classic should not be used concurrently with MAO inhibitors such as tranylcypromine, tricyclic antidepressants, as well as drugs that increase blood pressure. Combined therapy with these groups of drugs can lead to increased vasoconstrictor action and increased blood pressure.
special instructions
Before instillation of the drug must be removed contact lenses and install them 15 minutes after instillation. It is necessary to avoid direct contact of the drug with soft contact lenses because of a possible violation of their transparency. It is possible that reactive hyperemia of the conjunctiva and nasal mucosa may develop (medical rhinitis) due to improper use of the drug. The patient should be informed that when intense eye pain occurs, a strong acute or unilateral redness of the eyes, headache, visual disturbances, the appearance of blemishes in front of the eyes or double vision in the eyes, you should immediately consult a doctor. irritation or hyperemia is associated with serious diseases of the organ of vision, such as an infection, a foreign body or chemical trauma of the cornea, an eye specialist should be consulted. Avoid prolonged use and overdose of the drug, especially in children. The patient should be informed that the expiration date has expired or should not be disposed of in sewage or on the street. It is necessary to put the drug in the bag and put it in the trash. These measures will help protect the environment. Impact on the ability to drive vehicles and control mechanisms In rare cases, after applying eye drops, blurred vision occurs, which can affect the ability to drive a car or machinery.