Almagel A suspension for oral administration 170 ml
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Active ingredients
Algeldrat + Benzocaine + Magnesium hydroxide
Release form
Suspension
Composition
5 ml (1 scool) contains: Active substances: allegrite (aluminum hydroxide gel) 2.18 g, which corresponds to the aluminum oxide content of 218 mg; magnesium hydroxide paste 350 mg, which corresponds to the content of magnesium oxide 75 mg; benzocaine 109 mg. Adjuvants: sorbitol - 801.15 mg, gietelloza - 15.26 mg, methyl parahydroxybenzoate - 10.9 mg, propyl parahydroxybenzoate - 1.363 mg, butyl parahydroxybenzoate - 1.363 mg, sodium saccharinate dihydrate - 0.818 mg, 0.818 mg, 0.818 mg, 0.818 mg, 0.818 mg, 0188, 018 mg, 0188, 018 mg, 0188 mg, sodium diarrheroxybenzoate, 1.363 mg, 1.363 mg, 1363 mg, 1363 mg of sorbitol, 1.363 mg; mg, purified water - up to 5 ml.
Pharmacological effect
The instruction was approved by the Pharmacological Committee of the Ministry of Health of Russia on March 2, 2001. Almagel A neutralizes free hydrochloric acid in the stomach, which leads to a decrease in the digestive activity of gastric juice. Does not cause secondary hypersecretion of gastric juice. It has a local anesthetic, adsorbing and enveloping effect, reduces the influence of damaging factors on the mucous membrane. The therapeutic effect after taking the drug comes in 3-5 minutes and lasts an average of 70 minutes. Almagel A provides prolonged local neutralization of continuously separated gastric juice and reduces its hydrochloric acid content to optimal boundaries for treatment. Aluminum hydroxide suppresses pepsin secretion, neutralizes hydrochloric acid, forming aluminum chloride, which is converted into alkaline aluminum salts in the alkaline medium of the intestine. Magnesium hydroxide also neutralizes hydrochloric acid, turning into magnesium chloride. Thus, the effect of aluminum hydroxide, which causes constipation, is counteracted. Magnesium hydroxide and magnesium chloride are resorbed to an insignificant degree and have practically no effect on the concentration of magnesium ions in the blood. Benzocaine has an effective and long-lasting local analgesic effect in case of severe pain syndrome. Sorbitol, which is part of the preparation, promotes enhanced secretion of bile and exhibits a mild laxative effect, complementing the action of magnesium hydroxide. Almagel A does not sharply raise the pH of the contents of the stomach, buffers its value from 4.0–4.5 to 3.5–3.8 (physiological value) in the period between doses.The drug forms a protective layer, ensuring uniform distribution of active substances on the gastric mucosa and has a long-lasting local effect without subsequent formation of carbon dioxide in the stomach, which, in turn, causes flatulence, a feeling of heaviness in the epigastric region and secondary enhancement of hydrochloric acid secretion. According to the classification of Hodge and Sterner, the drug when administered orally is a weakly toxic agent and does not have embryotoxic, teratogenic and mutagenic effects. In some cases, increased tendon reflexes were observed in newborns whose mothers took the drug for a long time. In addition, in newborns there is a risk of hypermagnesia, especially in the state of dehydration, therefore prolonged use of the drug is not recommended for pregnant women and newborns.
Pharmacokinetics
Almagel A is a nonabsorbable drug. If the correct dosing regimen and the duration of treatment are observed, it is practically not resorbed in the gastrointestinal tract and has a long-lasting uniform effect without disturbing the electrolyte balance and without creating the danger of alkalosis or other metabolic disorders. It does not irritate the urinary system and with prolonged use does not cause alkalosis and the formation of stones in the urinary tract.
Indications
Peptic ulcer of the stomach and duodenum in the acute phase. Acute gastritis and chronic gastritis with increased and normal secretory function in the acute phase. Duodenitis. Enteritis. Hernia of the esophageal opening of the diaphragm. Reflux esophagitis. errors in the diet, after drinking coffee, nicotine, alcohol. Preventive in the treatment of SCS and NPVS. Diabetes (in the complex of therapeutic measures).
Contraindications
Hypersensitivity to the drug components. Severe renal dysfunction. Alzheimer's disease. Early childhood (up to 1 month). Pregnancy. Breastfeeding period.
Precautionary measures
With long-term intake, it is necessary to ensure adequate intake of phosphorus from food.
Use during pregnancy and lactation
It is not recommended to prescribe Almagel A for longer than 3 days during pregnancy.Avoid prescribing to nursing mothers.
Dosage and administration
Inside Adults: as prescribed by a doctor, 1-3 dosing (teaspoons), depending on the severity of the case, 3-4 times / day for half an hour before meals and in the evening before bedtime. Children: strictly prescribed by a doctor. Till 10 years: 1/3 doses for adults. From 10 to 15 years: - 1/2 dose for adults. For diseases accompanied by nausea, vomiting and abdominal pain, treatment begins with Almagel A, and after the disappearance of the symptoms listed above, they go on to receive Almagel. Before taking the bottle should be shaken.
Side effects
On the part of the organs of the LCIT, a change in taste, nausea, vomiting, stomach cramps, epigastric pain and constipation, which disappear after dose reduction. On the part of the metabolism: The development of phosphorus deficiency in the body, increased resorption and excretion of calcium in the urine, hypermagnesium. Others Drowsiness, osteomalacia, edema of the extremities (against the background of chronic renal failure), dementia.
Overdose
Symptoms: depression of gastrointestinal motility. Treatment: the appointment of laxatives.
Interaction with other drugs
With simultaneous use, Almagel A can reduce the therapeutic effect of tetracycline antibiotics, histamine H2-receptor blockers, digitalis glycosides, iron salts, ciprofloxacin, phenothiazines, isoniazid, beta-adrenergic blockers, indomethacin and ketokenosol, etc.
special instructions
The interval between taking Almagel A and other medicines should be 1-2 hours. It is not recommended to take the drug in doses greater than 16 spoons per day, or if such a dose is used, the duration of the course of treatment should be no more than 2 weeks. With long-term use of the drug should ensure adequate intake of phosphorus from food.