Ambrobene solution for intravenous administration of an ampoule 2 ml 5 pcs
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Active ingredients
Ambroxol
Composition
1 ml of 1 amp. Ambroxol Hydrochloride 7.5 mg 15 mg. Excipients: lactose, calcium citrate, sodium citrate, magnesium stearate. The composition of the shell: gelatin, titanium dioxide.
Pharmacological effect
Mucolytic and expectorant drug. Ambroxol - the active metabolite of bromhexine improves the rheological properties of sputum, reduces its viscosity and adhesive properties, contributing to its removal from the respiratory tract. Ambroxol stimulates the activity of serous cells of the glands of the bronchial membrane, the production of enzymes that break down the bonds between sputum polysaccharides, the formation of surfactant and the activity of the cilia of the bronchi directly, preventing them from sticking together. After ingestion, the therapeutic effect occurs after 30 minutes and lasts for 6-12 hours (depending on the dose taken). When administered parenterally, the effect of the drug comes quickly and lasts for 6-10 hours
Indications
The solution for injection is used for diseases of the respiratory tract with the release of viscous sputum and with the difficulty of sputum discharge in cases where it is necessary to obtain a rapid therapeutic effect or the drug cannot be taken orally: - acute and chronic bronchitis. - pneumonia. - bronchial asthma . - bronchiectasis. - stimulation of the synthesis of surfactant in respiratory distress syndrome in premature babies and newborns (as part of complex therapy). The solution for oral administration and inhalation is used for diseases of the respiratory tract with the release of viscous sputum and with the difficulty of sputum discharge: - acute and chronic bronchitis. - pneumonia. - bronchial asthma . - bronchiectasis.
Contraindications
- gastric ulcer and duodenal ulcer - epileptic syndrome - hypersensitivity to ambroxol and / or other components of the drug. With caution should use the drug in violation of kidney function and / or severe liver disease, reducing the dose and increasing the time between taking the drug (treatment in such cases should be carried out under medical supervision). With extreme caution and only under the supervision of a physician, Ambrobene should be used in violation of the motility of the bronchi and large volumes of secreted secretion in order to avoid the danger of a congestion of the secretion in the bronchi.
Use during pregnancy and lactation
Since so far there are no reliable data on the negative effects of ambroxol on the fetus and newborn, it is possible to use Ambrobene during pregnancy, especially in the first trimester, and during breastfeeding only in the case when the intended benefit to the mother outweighs the potential risk to the fetus.
Dosage and administration
The solution for ingestion and inhalation is taken orally after a meal with a sufficient amount of liquid (water, juice, tea) with the help of a measuring cup. 1 ml of solution contains 7.5 mg of ambroxol. Children under 2 years old should be prescribed 1 ml of the solution 2 times / day (15 mg / day). For children aged 2 to 6 years, the drug is prescribed in 1 ml of solution 3 times / day (22.5 mg / day). Children between the ages of 6 and 12 are prescribed 2 ml of the solution 2-3 times / day (30-45 mg / day). In adults and adolescents, in the first 2-3 days, 4 ml of the solution is prescribed 3 times / day (90 mg / day). In the following days - 4 ml 2 times / day (60 mg / day). When using Ambrobene in the form of inhalation, any modern equipment is used (except steam inhalation). Before inhalation, the drug should be mixed with a 0.9% solution of sodium chloride (for optimal moistening of the air can be diluted in a 1: 1 ratio) and heated to body temperature. Inhalation should be carried out in the mode of normal breathing, so as not to provoke cough tremors. In patients with bronchial asthma, in order to avoid non-specific irritation of the respiratory tract and their spasm, bronchodilators should be used before inhalation of ambroxol. Children under the age of 2 years old inhalate 1 ml of solution 1-2 times / day (7.5-15 mg / day). In children aged 2 to 6 years old, 2 ml of the solution is injected 1-2 ml / day (15-30 mg / day). Adults and children over the age of 6 years are inhaled with 2-3 ml of solution 1-2 times / day (15-45 mg / day). The solution for injection should be administered in / in (slowly jet or drip). As a solvent, use a 0.9% solution of sodium chloride, 5% dextrose solution, Ringer-Locke solution or another basic solution with a pH not higher than 6.3. Children usually prescribed the drug in a daily dose at the rate of 1.2-1.6 mg / kg body weight. Children under the age of 2 years should be prescribed 1 ml (1/2 amp.) 2 times / day (15 mg / day). Children aged 2 to 6 years old should be prescribed 1 ml (1/2 amp.) 3 times / day (22.5 mg / day). Children over the age of 6 years, appoint 2 ml (1 amp.) 2-3 times / day (30-45 mg / day). Adults appoint 1 amp. 2-3 times / day (30-45 mg / day).In severe cases, the dose may be increased to 2 amp. 2-3 times / day (60-90 mg / day). In respiratory distress syndrome in newborns and premature babies, the daily dose of the drug is 30 mg and, as a rule, is divided into 4 separate administrations. Injections stop after the disappearance of the acute manifestations of the disease and go on ingestion of other dosage forms Ambrobene. Treatment of children under the age of 2 years should be carried out only under the supervision of a physician. During the use of the drug is recommended to drink plenty of fluids. The duration of treatment depends on the characteristics of the course of the disease. It is not recommended to use the drug without medical prescription for more than 4-5 days.
Side effects
On the part of the digestive system: rarely - salivation, gastralgia, nausea, vomiting, diarrhea, constipation. On the part of the respiratory system: rarely - dry mouth and respiratory tract, rhinorrhea. Allergic reactions: very rarely - skin rash, angioedema of the face, respiratory failure, temperature reaction with chills. in some cases, contact dermatitis. recorded one case of anaphylactic shock. Others: weakness, headache, dysuria, rash. With rapid on / in the introduction: intense headaches, fatigue and heaviness in the legs, torpor, increased blood pressure, shortness of breath, hyperthermia, chills.
special instructions
On the part of the digestive system: rarely - salivation, gastralgia, nausea, vomiting, diarrhea, constipation. On the part of the respiratory system: rarely - dry mouth and respiratory tract, rhinorrhea. Allergic reactions: very rarely - skin rash, angioedema of the face, respiratory failure, temperature reaction with chills. in some cases, contact dermatitis. recorded one case of anaphylactic shock. Others: weakness, headache, dysuria, rash. With rapid on / in the introduction: intense headaches, fatigue and heaviness in the legs, torpor, increased blood pressure, shortness of breath, hyperthermia, chills.