Amelotex pills 15 mg 20 pcs
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Active ingredients
Meloxicam
Release form
Pills
Composition
Meloxicam 15 mg Auxiliary substances: lactose monohydrate - 71.22 mg, microcrystalline cellulose - 55.8 mg, sodium citrate - 18 mg, povidone - 5.4 mg, crospovidone - 10.8 mg, colloidal silicon dioxide - 1.44 mg, magnesium stearate - 2.34 mg
Pharmacological effect
NSAIDs. It has analgesic, anti-inflammatory and antipyretic effects. Anti-inflammatory effect is associated with inhibition of the enzymatic activity of COX-2, which is involved in the biosynthesis of prostaglandins in the area of inflammation. To a lesser extent, meloxicam acts on COX-1, which is involved in the synthesis of prostaglandin, which protects the gastrointestinal mucosa and is involved in the regulation of blood flow in the kidneys. Inhibits prostaglandin synthesis in the area of inflammation to a greater extent than in the gastric mucosa or kidneys, which is associated with relatively selective inhibition of COX-2. It belongs to the class of oxycams, a derivative of enolic acid. Meloxicam is a “chondron-neutral” drug that does not adversely affect cartilage tissue, does not affect the synthesis of proteoglycan by articular cartilage chondrocytes.
Indications
rheumatoid arthritis . osteoarthritis. ankylosing spondylitis (ankylosing spondylitis). inflammatory and degenerative diseases of the joints, accompanied by pain.
Contraindications
hypersensitivity to the active substance or auxiliary components. period after coronary artery bypass surgery. uncompensated heart failure. anamnestic data about the attack of bronchial obstruction, rhinitis. complete or incomplete combination of bronchial asthma, recurrent nasal polyposis and paranasal sinuses and intolerance to acetylsalicylic acid and other NSAIDs (including a history of). erosive and ulcerative changes in the gastric or duodenal mucosa, active gastrointestinal bleeding. inflammatory bowel disease (ulcerative colitis, Crohn's disease). cerebrovascular or other bleeding. severe liver failure or liver disease in the active phase. severe renal failure in patients not undergoing dialysis (C creatinine less than 30 ml / min), progressive kidney disease, incl.confirmed hyperkalemia. pregnancy breastfeeding period. age up to 15 years. C caution: to reduce the risk of adverse events, use the minimum effective dose, if possible, with a shorter course, for ischemic heart disease, cerebrovascular diseases, congestive heart failure, dyslipidemia / hyperlipidemia, diabetes mellitus, peripheral artery disease, smoking, Cl of creatinine less than 60 ml / min , history of ulcerative lesions of the gastrointestinal tract, the presence of Helicobacter pylori infection, in old age, with prolonged use of NSAIDs, frequent use of alcohol, severe somatic their diseases, concomitant therapy with the following drugs: anticoagulants (for example, warfarin), antiplatelet agents (for example acetylsalicylic acid, clopidogrel), oral GCS (for example, prednisolone), SIOZS (for example, citalopram, fluoxetine, paroxetine, sertralin).
Use during pregnancy and lactation
The drug is contraindicated in pregnancy and lactation (breastfeeding). Suppression of prostaglandin synthesis can have an undesirable effect on the course of pregnancy and fetal development. It is known that NSAIDs penetrate into breast milk, so Amelotex. not recommended for use during breastfeeding. The use of meloxicam, as well as other drugs that block the synthesis of prostaglandins, can affect fertility, so it is not recommended for women who are planning a pregnancy.
Dosage and administration
V / m, deep - at 7.5-15 mg / day. With a slight or moderate decrease in renal function (Cl creatinine greater than 25 ml / min), as well as liver cirrhosis in a stable clinical state, dose adjustment is not required. The initial dose in patients with an increased risk of side effects is 7.5 mg / day. The maximum daily dose is 15 mg, and in patients with severe renal insufficiency on hemodialysis, it is 7.5 mg.
Side effects
On the part of the digestive system: nausea, vomiting, belching, abdominal pain, constipation or diarrhea, flatulence, increased activity of hepatic transaminases, hyperbilirubinemia, stomatitis, erosive and ulcerative lesions of the gastrointestinal tract, esophagitis, gastritis, colitis, gastrointestinal perforation, gastrointestinal (hidden or overt), hepatitis.On the part of the nervous system: dizziness, vertigo, headache, tinnitus, confusion, drowsiness, disorientation, emotional lability. On the part of the respiratory system: bronchospasm. From the side of blood-forming organs: anemia, leukopenia, thrombocytopenia. On the part of the cardiovascular system: peripheral edema, increased blood pressure, rush of blood to the skin of the face and upper chest, heartbeat. On the part of the urinary system: edema, hypercreatininemia, increasing the concentration of urea in the blood serum. rarely, acute renal failure, interstitial nephritis, albuminuria, hematuria. From the sense organs: conjunctivitis, disturbance (including fuzziness) of vision. On the part of the skin: itching, skin rash, urticaria, photosensitivity, bullous rash, erythema multiforme, toxic epidermal necrolysis. Allergic reactions: angioedema, anaphylactoid, anaphylactic reactions. Local reactions: possible burning and pain at the injection site.
special instructions
On the part of the digestive system: nausea, vomiting, belching, abdominal pain, constipation or diarrhea, flatulence, increased activity of hepatic transaminases, hyperbilirubinemia, stomatitis, erosive and ulcerative lesions of the gastrointestinal tract, esophagitis, gastritis, colitis, gastrointestinal perforation, gastrointestinal (hidden or overt), hepatitis. On the part of the nervous system: dizziness, vertigo, headache, tinnitus, confusion, drowsiness, disorientation, emotional lability. On the part of the respiratory system: bronchospasm. From the side of blood-forming organs: anemia, leukopenia, thrombocytopenia. On the part of the cardiovascular system: peripheral edema, increased blood pressure, rush of blood to the skin of the face and upper chest, heartbeat. On the part of the urinary system: edema, hypercreatininemia, increasing the concentration of urea in the blood serum. rarely, acute renal failure, interstitial nephritis, albuminuria, hematuria. From the sense organs: conjunctivitis, disturbance (including fuzziness) of vision. On the part of the skin: itching, skin rash, urticaria, photosensitivity, bullous rash, erythema multiforme, toxic epidermal necrolysis. Allergic reactions: angioedema, anaphylactoid, anaphylactic reactions.Local reactions: possible burning and pain at the injection site.