Aminazin-valenta 25mg coated pills N10
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Description
Coated pills "Aminazin" 25 mg - antipsychotic agent (neuroleptic) from the group of phenothiazine derivatives. It has a pronounced antipsychotic, sedative, antiemetic effect. Weakens or completely eliminates delusions and hallucinations, suppresses psychomotor agitation, reduces affective reactions, anxiety, anxiety, reduces motor activity. The mechanism of antipsychotic action is associated with the blockade of postsynaptic dopaminergic receptors in the mesolimbic structures of the brain. It also has a blocking effect on α-adrenoreceptors and suppresses the release of pituitary and hypothalamic hormones. However, the blockade of dopamine receptors increases the secretion of prolactin by the pituitary gland. The central antiemetic effect is due to the inhibition or blockade of dopamine D2 receptors in the chemoreceptor trigger zone of the cerebellum, and the peripheral blockade of the vagus nerve in the gastrointestinal tract. The antiemetic effect is enhanced, apparently due to anticholinergic, sedative and antihistamine properties. Sedative effect is caused, apparently, by alpha-adreno-blocking activity. It has a moderate or weak extrapyramidal effect.
Release form
Pills
Composition
Chlorpromazine hydrochloride, potato starch, microcrystalline cellulose, lactose monohydrate, copovidone, croscarmellose sodium, magnesium stearate.
Indications
Chronic paranoid and hallucinatory-paranoid states, states of psychomotor agitation in schizophrenia (hallucinatory-delusional, hebephrenic, catatonic syndromes), alcoholic psychosis, manic arousal in manic-depressive psychosis, mental disorders in case of epilepsy, manic agitation in a manic-depressive psychosis, mental disorders in case of epilepsy, manic arousal in a manic-depressive psychosis, mental disorders in case of epilepsy, manic arousal in a manic-depressive psychosis, mental disorders in case of epilepsy, manic agitation in a manic-depressive psychosis; depressive psychosis, as well as other diseases accompanied by agitation, tension. Neurotic diseases accompanied by increased muscle tone. Persistent pain, incl. causalgia (in combination with analgesics), persistent sleep disorders (in combination with hypnotics and tranquilizers). Meniere's disease, pregnant vomiting, treatment and prevention of vomiting in the treatment of antitumor agents and during radiation therapy. Itchy dermatosis.As part of "lytic mixtures" in anesthesiology.
Precautionary measures
The drug is available on prescription.
Use during pregnancy and lactation
If necessary, the use of chlorpromazine during pregnancy should limit the treatment time, and at the end of pregnancy, if possible, reduce the dose. It should be borne in mind that chlorpromazine prolongs labor. If necessary, breastfeeding should be discontinued during lactation. Chlorpromazine and its metabolites penetrate the placental barrier, excreted in breast milk. Clinical studies have shown that chlorpromazine can have a teratogenic effect. When using chlorpromazine in high doses during pregnancy in newborns, in some cases, digestive disorders associated with atropin-like effect, extrapyramidal syndrome were noted.
Dosage and administration
Installed individually. When ingested for adults, a single dose is 10-100 mg, a daily dose is 25-600 mg, for children aged 1-5 years - 500 mg / kg every 4-6 hours, for children over 5 years old can be applied 1 / 3-1 / 2 adult doses. Frequency of oral or parenteral administration depends on the indications and the clinical situation. Maximum single doses: for adults when administered orally - 300 mg. Maximum daily doses: for adults when administered orally - 1.5 g, for children in age younger than 5 years (body weight up to 23 kg) when administered orally, in a / m or w / in the introduction - 40 mg, for children over the age of 5 years (wt. Sa body more than 23 kg) when taken orally, in / m or / in the introduction - 75 mg.
Side effects
From the side of the central nervous system: possible akathisia, blurred vision, rarely - dystonic extrapyramidal reactions, parkinson syndrome, tardive dyskinesia, disturbances of thermoregulation, ZNS, in isolated cases - convulsions. Cardiovascular system: possible arterial hypotension ), tachycardia. From the digestive system: dyspeptic phenomena are possible (by ingestion), rarely - cholestatic jaundice. From the hematopoietic system: rarely - leukopenia, agranulocytosis. From the urinary tract STEM: rarely - difficulty mocheispuskaniya.So the Endocrine: menstrual irregularities, impotence, gynecomastia,increase in body weight. Allergic reactions: skin rash, itching, rarely - exfoliative dermatitis, erythema multiforme are possible. Dermatological reactions: rarely - skin pigmentation, photosensitization. On the part of the organ of vision: long-term use in high doses may cause chlorpromazine in the anterior structures of the eye ( cornea and lens), which can accelerate the processes of normal aging of the lens.
Interaction with other drugs
With the simultaneous use of drugs that have a depressant effect on the central nervous system, ethanol, ethanol-containing drugs may increase the inhibitory effect on the central nervous system, as well as respiratory depression. With the simultaneous use of tricyclic antidepressants, maprotiline, MAO inhibitors may increase the risk of developing ZNS. may reduce the threshold of convulsive readiness, with the means for the treatment of hyperthyroidism - increased risk of developing agranulocytosis, with the drug and causing extrapyramidal reactions - it is possible to increase the frequency and severity of extrapyramidal disorders with drugs that cause arterial hypotension - an additive effect on blood pressure is possible, which leads to severe arterial hypotension, increased orthostatic hypotension. - increased anticholinergic action, with anticholinesterase agents - muscular weakness, worsening of myasthenia gravis. simultaneous use with antacids containing aluminum and magnesium hydroxide, the concentration of chlorpromazine in the blood plasma decreases due to a violation of its absorption from the gastrointestinal tract. With simultaneous use of barbiturates, chlorpromazine increases metabolism, inducing microsomal liver enzymes and thus reducing its concentration in the blood plasma. contraceptives for oral administration described a case of increasing the concentration of chlorpromazine in the blood plasma. When used simultaneously with epinephrine POSSIBILITY "distortion" pressor action of epinephrine, thereby causing only β-adrenoceptor stimulation and severe hypotension occur and tahikardiya.Pri simultaneous application with amitriptyline increased risk of tardive dyskinesia.Cases of the development of paralytic ileus are described. With simultaneous use, chlorpromazine may reduce or even completely inhibit the antihypertensive effect of guanethidine, although some patients may show the hypotensive effect of chlorpromazine. If used simultaneously with diazoxide, pronounced hyperglycemia may occur, with potentiation of hyperpirectomy, it will be unacculated. sedative effect, with zopiklon - possibly increased sedative action, with imipramine - increases their concentration ipramine in the blood plasma. With simultaneous use of chlorpromazine inhibits the effects of levodopa due to the blockade of dopamine receptors in the central nervous system. Increased extrapyramidal symptoms are possible. With simultaneous use of lithium carbonate, pronounced extrapyramidal symptoms, neurotoxic effects, with morphine, myoclonus may develop. Simultaneous use of nortriptyline in patients with schizophrenia may worsen the clinical condition, despite elevated levels of chlorpromazine in the blood plasma. Cases of the development of paralytic ileus are described. When used simultaneously with piperazine, a case of convulsions is described, with propranolol - an increase in plasma concentrations of propranolol and chlorpromazine, with trazodone - arterial hypotension is possible, with trihexyphenidyl - there are reports of the development of paralytic ileus, with a figure, with the number of cases, the development of paralytic Ileus, severe hyperpyrexia, with phenytoin - may increase or decrease the concentration of phenytoin in the blood plasma. With simultaneous use with fluoxetine increases the risk development of extrapyramidal symptoms, with chloroquine, sulfadoxin / pyrimethamine, the concentration of chlorpromazine in the blood plasma increases with the risk of the toxic effect of chlorpromazine. If cisapride is used simultaneously, the QT interval on the ECG is additively prolonged. If it is used simultaneously with cimetidine, the concentration of chlorpromazine in the blood plasma can be reduced in the plasma of the ECG. There is also evidence to suggest an increase in the concentration of chlorpromazine in the blood plasma. With simultaneous use of ephedrine, the vasoconstrictor effect of ephedrine may be weakened.
special instructions
Contraindications.Disorders of the liver, kidneys, blood-forming organs, progressive systemic diseases of the brain and spinal cord, myxedema, severe cardiovascular diseases, thromboembolic disease, late bronchiectasis, closed-angle glaucoma, urinary retention, associated with prostatic hyperplasia, pronounced central nervous system depression, comatosis condition, brain injury. With particular caution, phenothiazines are used in patients with pathological changes in the blood picture, in disorders of liver function, alcohol intoxication, Reye's syndrome, as well as in breast cancer, cardiovascular diseases, susceptibility to the development of glaucoma, Parkinson's disease, gastric ulcer and duodenal ulcer. , urinary retention, chronic diseases of the respiratory system (especially in children), and epileptic seizures. Phenothiazines should be used with caution in elderly patients ( risk of excessive sedative and hypotensive action) in exhausted and debilitated patients. In the event of hyperthermia, which is one of the symptoms of ZNS, chlorpromazine should be immediately canceled. In children, especially with acute diseases, extrapyramidal symptoms are more likely to occur when using phenothiazines. The treatment period does not allow the use of alcohol. The effect on the ability to drive vehicles and control mechanisms. It should be used with caution in patients engaged in potentially hazardous activities that require a high rate of psychomotor reactions.