Aminocaproic acid solution for infusion 5% 100ml
Condition: New product
1000 Items
Rating:
Be the first to write a review!
More info
Active ingredients
Aminocaproic acid
Release form
Solution
Composition
Aminocaproic acid 50 g Excipients: sodium chloride - 9 g, water d / and - up to 1 l.
Pharmacological effect
Hemostatic agent, an inhibitor of fibrinolysis. It blocks the action of plasminogen activators, inhibits the action of plasmin, partially inhibits kinins. It also has some antiallergic activity and slightly increases the antitoxic function of the liver.
Pharmacokinetics
After ingestion, it is rapidly absorbed from the gastrointestinal tract, Cmax in the blood plasma is reached after 2 hours. It is widely distributed in the body and is rapidly excreted in the urine, mostly unchanged. The final T1 / 2 is about 2 hours.
Indications
To stop bleeding during surgical interventions and various pathological conditions, accompanied by increased fibrinolytic activity of the blood and tissues (after operations on the lungs, prostate, pancreas and thyroid gland). Prevention of the development of secondary hyperfibrinogenemia with massive transfusions of canned blood.
Contraindications
Tendency to thrombosis and embolism, impaired renal function, hypersensitivity to aminocaproic acid.
Use during pregnancy and lactation
It is inappropriate to use women for the prevention of increased blood loss during childbirth, because possible occurrence of thromboembolic complications.
Dosage and administration
Adults: inside - 5-30 g / day in 3-6 receptions; 4-5 g are introduced into / in the first hour, then 1 g / h. The maximum daily dose is 30 g. For children: IV is administered at the rate of 100 mg / kg in the first hour, then 33 mg / kg / h. The maximum daily dose is 18 g / m2.
Side effects
Since the cardiovascular system: arterial hypotension, bradycardia, arrhythmias. On the part of the digestive system: nausea, diarrhea. Other: catarrhal phenomena of the upper respiratory tract, dizziness.
special instructions
Caution should be used in disorders of cerebral circulation. The introduction of aminocaproic acid in hematuria is not recommended (due to the risk of developing acute renal failure).