Arbidol 50mg coated pills N20
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Description
Film coated pills Arbidol is a drug with immunomodulatory and antiviral effects.
Active ingredients
Umifenovir
Release form
Pills
Composition
Umifenovir 50 mg. Excipients: potato starch - 31.86 mg, microcrystalline cellulose - 57.926 mg, povidone K30 (collidon 30) - 8.137 mg, calcium stearate - 0.535 mg, croscarmellose sodium (primelloza) - 1.542 mg. The composition of the shell: hypromellose (hydroxypropylmethyl cellulose) - 4.225 mg, titanium dioxide - 1.207 mg, macrogol 4000 (polyethylene glycol 4000) - 0.471 mg, polysorbate 80 (twin 80) - 0.097 mg, or Advantia Prime (Advantia Prime) - 6 mg [hypromellose ( hydroxypropyl methylcellulose) - 4.225 mg, titanium dioxide - 1.207 mg, macrogol 4000 (polyethylene glycol 4000) - 0.471 mg, polysorbate 80 (twin 80) - 0.097 mg], or Aquarius Prime White (Aquarius Prime White) - 6 mg [hypromellose (hydroxypropylmethylcellulose) - 4.225 mg, titanium dioxide - 1.207 mg, macrogol 4000 (polyethylene glycol 4000) - 0.471 mg, polysorbate 80 (twin 80) - 0.097 mg].
Pharmacological effect
Antiviral drug. It specifically inhibits influenza A and B viruses, a coronavirus associated with severe acute respiratory syndrome (SARS). The mechanism of antiviral action refers to fusion inhibitors (fusions), interacts with the hemagglutinin of the virus and prevents the fusion of the lipid envelope of the virus and cell membranes. It has a moderate immunomodulatory effect. It has interferon-inducing activity, stimulates humoral and cellular immunity reactions, the phagocytic function of macrophages, increases the body's resistance to viral infections. Reduces the incidence of complications associated with viral infection, as well as exacerbations of chronic bacterial diseases. Therapeutic efficacy in viral infections is manifested in reducing the severity of general intoxication and clinical phenomena, reducing the duration of the disease, reducing the risk of complications. It refers to low-toxic drugs (LD50> 4 g / kg). It does not have any negative effects on the human body when administered orally at recommended doses.
Pharmacokinetics
Absorption and distribution: quickly absorbed and distributed to organs and tissues. Cmax in plasma when taken in a dose of 50 mg is reached after 1.2 h, at a dose of 100 mg - after 1.5 h. Metabolism and excretion: metabolized in the liver. T1 / 2 is 17-21 hours.About 40% is excreted unchanged, mainly with bile (38.9%) and in small amounts by the kidneys (0.12%). During the first day, 90% of the administered dose is eliminated.
Indications
Prevention and treatment in adults and children: influenza A and B, acute respiratory viral infections, severe acute respiratory syndrome (SARS) (including those complicated by bronchitis, pneumonia), secondary immunodeficiency states, complex therapy of chronic bronchitis, pneumonia and recurrent herpes infection. Combined therapy of acute intestinal infections of rotavirus etiology in children over 3 years old. Prevention of postoperative infectious complications and normalization of the immune status.
Contraindications
Contraindications: children up to 3 years, hypersensitivity to the drug.
Use during pregnancy and lactation
Data on the use of the drug Arbidol during pregnancy and during breastfeeding is not provided.
Dosage and administration
The drug is taken orally before meals. Single dose: children aged 3 to 6 years old - 50 mg, children aged 6 to 12 years old - 100 mg, children over 12 years old and adults - 200 mg (2 pills of 100 mg or 4 pills of 50 mg ). Non-specific prophylaxis: in direct contact with patients with influenza and other acute respiratory viral infections, children aged 3 to 6 years old are prescribed 50 mg each, children aged 6 to 12 years old - 100 mg each, children over 12 years old and adults 200 mg 1 time / day for 10-14 days. During the epidemic of influenza and other acute respiratory viral infections, to prevent exacerbations of chronic bronchitis, recurrence of herpes infection is prescribed to children aged 3 to 6 years - 50 mg, children aged 6 to 12 years - 100 mg, children over 12 years old and adults - 200 mg 2 times a week for 3 weeks. For the prevention of SARS (in contact with patients), adults and children over 12 years old are prescribed 200 mg 1 time per day for 12-14 days. For the prevention of postoperative complications prescribed to children aged 3 to 6 years - 50 mg, children aged 6 to 12 years - 100 mg, children over 12 years old and adults - 200 mg 2 days before surgery, then 2-5 days after operation. Treatment: for uncomplicated flu and other acute respiratory viral infections: children aged 3 to 6 years old - 50 mg, children aged 6 to 12 years old - 100 mg, children over 12 years old and adults - 200 mg 4 times / day (every 6 h) within 5 days, for the treatment of influenza and other acute respiratory viral infections with the development of complications (bronchitis, pneumonia), 50 mg are prescribed to children aged from 3 to 6 years, 100 mg are prescribed to children aged from 6 to 12, children over 12 years old and adults - 200 mg 4 times / day (every 6 hours) for 5 days, then a single dose is administered once a week for 4 weeks. Severe acute respiratory syndrome (SARS): adults and children over 12 years old - 200 mg 2 times / day for 8-10 days.Combined therapy of chronic bronchitis, herpes infection: children aged 3 to 6 years old - 50 mg, children aged 6 to 12 years old - 100 mg, children over 12 years old and adults 200 mg 4 times / day (every 6 hours) within 5-7 days, then a single dose is prescribed 2 times a week for 4 weeks. Combined therapy of acute intestinal infections of rotavirus etiology in children over 3 years old: children aged 3 to 6 years old - 50 mg, children aged 6 to 12 years old - 100 mg, children over 12 years old - 200 mg 4 times / day (every 6 h) within 5 days.
Side effects
Seldom: allergic reactions.
Overdose
Unchecked.
Interaction with other drugs
When prescribing with other drugs, no negative effects were noted.
special instructions
It does not exhibit central neurotropic activity and can be used in medical practice for prophylactic purposes in practically healthy individuals of various professions, including requiring increased attention and coordination of movements (drivers of vehicles, operators, etc.).