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Active ingredients
Umifenovir
Release form
Capsules
Composition
Active ingredient: Umifenovir (Umifenovir) Concentration of active ingredient (mg): 100
Pharmacological effect
Antiviral drug. It specifically inhibits influenza A and B viruses, a coronavirus associated with severe acute respiratory syndrome (SARS-associated coronavirus). The mechanism of antiviral action refers to fusion inhibitors (fusions), interacts with the hemagglutinin of the virus and prevents the fusion of the lipid envelope of the virus and cell membranes. It has a moderate immunomodulatory effect. It has interferon-inducing activity, stimulates humoral and cellular immunity reactions, the phagocytic function of macrophages, increases the body's resistance to viral infections. Reduces the incidence of complications associated with viral infection, as well as exacerbations of chronic bacterial diseases. Therapeutic efficacy in viral infections manifests itself in reducing the severity of general intoxication and clinical phenomena, reducing the duration of the disease. It has a moderate immunomodulating effect. Applies to low-toxic drugs (LD50> 4 g / kg). It does not have any negative effects on the human body when administered orally at recommended doses.
Pharmacokinetics
Absorption and distributionQuickly absorbed from the gastrointestinal tract. C max in plasma with the use of umifenovir in a dose of 50 mg is achieved in 1.2 hours, in a dose of 100 mg - 1.5 hours. Umifenovir is rapidly distributed throughout the organs and tissues of the body. Metabolism and elimination Metabolized in the liver. T1 / 2 is 17-21 hours. About 40% is excreted unchanged, mainly with bile (38.9%) and in small amounts by the kidneys (0.12%). During the first day, 90% of the received dose is eliminated.
Indications
Prevention and treatment in adults and children: - influenza A and B, acute respiratory viral infections, severe acute respiratory syndrome (SARS) (including those complicated by bronchitis, pneumonia); - secondary immunodeficiency states; - complex therapy of chronic bronchitis, pneumonia and recurrent herpes infection. Prevention of postoperative infectious complications and normalization of the immune status. Complex therapy of acute intestinal infections of rotavirus etiology in children over 3 years old.
Contraindications
Hypersensitivity to the drug, age up to 3 years.
Precautionary measures
Do not exceed recommended doses.
Use during pregnancy and lactation
Data on the use of Arbidol during pregnancy and during breastfeeding is not provided.
Dosage and administration
Inside, before eating. Single dose: for children from 3 to 6 years old - 50 mg, from 6 to 12 years old - 100 mg, over 12 years old and for adults - 200 mg (2 capsules of 100 mg or 4 capsules of 50 mg). For non-specific prophylaxis: For direct contact with patients with influenza and other acute respiratory viral infections: children from 3 to 6 years old - 50 mg, from 6 to 12 years old - 100 mg, over 12 years old and adults - 200 mg once a day for 10-14 days. During the epidemic of influenza and other acute respiratory viral infections, to prevent exacerbations of chronic bronchitis, recurrence of herpes infection: children from 3 to 6 years old - 50 mg, from 6 to 12 years old - 100 mg, over 12 years old and adults - 200 mg twice a week for 3 weeks. For the prevention of SARS (in contact with patients): adults and children over 12 years old are prescribed 200 mg once a day. Children from 6 to 12 years old 100 mg once a day (before meals) for 12-14 days. Prevention of postoperative complications: children from 3 to 6 years old - 50 mg, from 6 to 12 years old - 100 mg, over 12 years old and adults - 200 mg 2 days before surgery, then 2 and 5 days after surgery. For treatment: Influenza, other acute respiratory viral infections without complications: children from 3 to 6 years old - 50 mg, from 6 to 12 years old - 100 mg, older 12 years and adults - 200 mg 4 times a day (every 6 hours) for 5 days. Influenza, other acute respiratory viral infections with complications (bronchitis, pneumonia, etc.): for children from 3 to 6 years old - 50 mg, from 6 to 12 years old - 100 mg, over 12 years old and adults - 2 00 mg 4 times a day (every 6 hours) for 5 days, then a single dose 1 time per week for 4 weeks. Severe acute respiratory syndrome (SARS): children over 12 years old and adults 200 mg 2 times a day for 8-10 days. In the complex treatment of chronic bronchitis, herpes infection: children from 3 to 6 years old - 50 mg, from 6 to 12 years old - 100 mg, over 12 years old and adults - 200 mg 4 times a day (every 6 hours ) for 5-7 days, then a single dose 2 times a week for 4 weeks. Complex therapy of acute intestinal infections of rotavirus etiology in children over 3 years old t: from 3 to 6 years - 50 mg, from 6 to 12 years - 100 mg, over 12 years - 200 mg 4 times a day (every 6 hours) for 5 days.
Side effects
Rarely - allergic reactions.
Overdose
Cases of drug overdose are not marked.
Interaction with other drugs
When prescribing with other drugs, no negative effects were noted.
special instructions
Influence on the ability to drive motor vehicles and control mechanisms. The drug does not show central neurotropic activity and can be used in medical practice for preventive purposes in practically healthy people of various professions requiring increased attention and psychomotor speed (including transport drivers, operators).