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Active ingredients
Umifenovir
Release form
Capsules
Composition
umifenovir 100 mg. Supplementary substances: potato starch - 30.14 mg, microcrystalline cellulose - 55.76 mg, colloidal silicon dioxide (aerosil) - 2 mg, povidone (kollidon 25) - 10.1 mg, calcium stearate - 2 mg.
Pharmacological effect
Arbidol is a drug with immunomodulatory and antiviral effects. Induces the synthesis of interferon, stimulates humoral and cellular immunity, phagocytic activity of macrophages. Specifically inhibits influenza A and B viruses. The mechanism of antiviral action is associated with the ability of the drug to suppress the fusion of the lipid membrane of the virus with cell membranes when the virus contacts the cell. Arbidol increases the body's resistance to viral infections, prevents the development of complications, normalizes immunological parameters. Causes prolonged protective effect. With influenza, the drug reduces intoxication, reduces the severity of catarrhal phenomena, reduces the period of fever and the overall duration of the disease.
Pharmacokinetics
Absorption and distribution Rapidly absorbed and distributed to organs and tissues. With a max, when taking a dose of 100 mg, it is reached in 1.5 hours. T1 / 2 is 17-21 hours. About 40% is excreted unchanged, mainly with bile (38.9%) and in small amounts by the kidneys (0.12%). During the first day, 90% of the received dose is eliminated.
Indications
Prevention and treatment in adults and children: - influenza A and B, ARVI, severe acute respiratory syndrome (SARS), incl. complicated by bronchitis and pneumonia; - secondary immunodeficiency states; - complex therapy of chronic bronchitis, pneumonia, and recurrent herpetic infection.
Contraindications
Children's age up to 3 years; hypersensitivity to the drug.
Precautionary measures
In 1 bottle 150 ml of mousse for intimate hygiene.
Use during pregnancy and lactation
Data on the use of Arbidol during pregnancy and during breastfeeding is not provided.
Dosage and administration
The drug is prescribed inside, before meals. A single dose for adults and children over 12 years old - 200 mg (2 capsules. 100 mg or 4 caps.50 mg), for children aged 6 to 12 years - 100 mg, from 3 to 6 years - 50 mg. For non-specific prophylaxis In direct contact with a sick flu and other acute respiratory viral infections in adults and children over 12 years old Arbidol is prescribed in a dose of 200 mg / day; children aged 6 to 12 years - 100 mg / day; children aged 3 to 6 years - 50 mg / day. The drug is taken 1 time / day. The course is 10-14 days. During the epidemic of influenza and other acute respiratory viral infections, for the prevention of exacerbation of chronic bronchitis and recurrence of herpes infection in adults and children over 12 years old, the drug is prescribed in a single dose of 200 mg; children aged 6 to 12 years - 100 mg; children aged 3 to 6 years - 50 mg. The drug is taken in 1 dose 2 times a week for 3 weeks. To prevent SARS (when in contact with a patient), adults and children over 12 years old are prescribed 200 mg 1 time / day for 12-14 days; children aged 6 to 12 years - 100 mg 1 time / day (before meals) for 12-14 days. To prevent postoperative infectious complications, the drug is prescribed for two days before surgery, then on the second and fifth day after surgery, 1 dose: adults and children over 12 years old - 200 mg, children aged 6 to 12 years old - 100 mg, from 3 to 6 years old - 50 mg. For treatment For flu and other acute respiratory viral infections without complications, adults and children over 12 years old are prescribed the drug 200 mg 4 times / day (every 6 hours), children aged 6 to 12 years old - 100 mg 4 times / day (every 6 hours), from 3 to 6 years old - 50 mg 4 times / day (each Dye 6 h. The course of treatment is 5 days. For influenza and other acute respiratory viral infections with the development of complications (including bronchitis, pneumonia), adults and children over 12 years old are prescribed Arbidol 200 mg 4 times / day (every 6 hours) for 5 days, then - 200 mg 1 time / week. within 4 weeks. Children from 6 to 12 years old are prescribed 100 mg 4 times / day (every 6 hours) and then 100 mg 1 time / week. within 4 weeks. Children from 3 to 6 years old should be prescribed 50 mg 4 times / day (every 6 hours) for 5 days, then 50 mg 1 time / week. for 4 weeks. For treatment of SARS, adults and children over 12 years old are prescribed 200 mg 2 times / day for 8-10 days. As part of complex therapy of chronic bronchitis and recurrent herpes infection, adults and children over 12 years old are prescribed 200 mg 4 times / day (every 6 hours) for 5-7 days, then 200 mg 2 times / week. within 4 weeks. Children aged 6 to 12 years, 100 mg 4 times / day (every 6 hours) for 5-7 days, then 100 mg 2 times / week. within 4 weeks. Children aged 3 to 6 years old are prescribed 50 mg 4 times / day (every 6 hours) for 5-7 days; then - 50 mg 2 times / week.within 4 weeks. As part of the complex treatment of acute intestinal infections of rotavirus etiology, children over 12 years old are prescribed 200 mg 4 times / day (every 6 hours) for 5 days, between 6 and 12 years old - 100 mg 4 times / day (every 6 hours) for 5 days, at the age of 3 to 6 years - 50 mg 4 times / day (every 6 hours) for 5 days.
Side effects
Seldom: allergic reactions.
Overdose
Cases of drug overdose are not marked.
Interaction with other drugs
When prescribing with other drugs, no negative effects were noted.
special instructions
Arbidol is recommended to be taken before meals. The drug does not show central neurotropic activity and can be used in medical practice for preventive purposes in practically healthy individuals of various professions requiring increased attention and psychomotor speed (including transport drivers, operators).