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Active ingredients
Bromhexine + Guaifenezin + Salbutamol
Release form
Pills
Composition
Active ingredient: salbutamol 2 mg. Bromhexine 8 mg. Guaifenesin 100 mg. Concentration of active ingredient (mg): 110 mg
Pharmacological effect
Pharmacological action - expectorant, mucolytic, bronchodilator.
Pharmacokinetics
Salbutamol: When ingested, absorption is high. Eating reduces the rate of absorption, but does not affect bioavailability. Communication with plasma proteins - 10%. Penetrates through the placenta. Subjected to presystemic metabolism in the liver and intestinal wall, is inactivated by phenol sulfotransferase to 4-o-sulfate ester. T1 / 2 - 3.8–6 hours. Excreted by the kidneys (69–90%), mainly as an inactive phenolsulfate metabolite (60%) for 72 hours and with bile (4%). The bioavailability of orally administered salbutamol is about 50%. Bromhexine: When administered orally, almost completely (99%) is absorbed in the gastrointestinal tract within 30 minutes. Bioavailability is low (the effect of the primary passage through the liver). It penetrates the placental barrier and the BBB. In the liver it undergoes demethylation and oxidation, it is metabolized to pharmacologically active ambroxol. T1 / 2 - 15 h (due to slow reverse diffusion from tissues). Excreted by the kidneys. When CRF disrupts metabolism. With repeated use may accumulate. Gvayfenezin: Absorption from the gastrointestinal tract is fast (25–30 minutes after ingestion). T1 / 2 - 1 h. Penetrates tissues containing acid mucopolysaccharides. Approximately 60% of the administered drug is metabolized in the liver. It is excreted by the lungs (with sputum) and kidneys, both unchanged and in the form of inactive metabolites.
Indications
As part of the combined treatment of acute and chronic broncho-pulmonary diseases, accompanied by the formation of difficult-to-discharge viscous secretions: bronchial asthma, tracheobronchitis, obstructive bronchitis, pneumonia, emphysema, whooping cough, pneumoconiosis, pulmonary tuberculosis, etc.
Contraindications
Hypersensitivity to the drug. Pregnancy, lactation. Tachyarrhythmia, myocarditis. Heart defects. Decompensated diabetes. Thyrotoxicosis. Glaucoma. Hepatic or renal failure.Peptic ulcer and duodenal ulcer in the acute stage. Gastric bleeding. Arterial hypertension. Children's age up to 6 years. With caution prescribed to patients with diabetes mellitus, gastric ulcer and duodenal ulcer in remission.
Precautionary measures
It should be carefully taken Ascoril patients with hyperthyroidism, diabetes, severe diseases of the cardiovascular system, arterial hypertension, gastric ulcer and duodenal ulcer.
Use during pregnancy and lactation
During pregnancy, the drug is not recommended. If necessary, drug treatment during lactation breastfeeding should be discontinued.
Dosage and administration
Inside Adults and children over 12 years old are prescribed 1 tablet 3 times a day. Children aged from 6 years to 12 years - 12 or 1 tablet 3 times a day. Children under the age of 6 years are recommended to use the syrup "Ascoril examiner."
Side effects
Rarely: when used in high doses, headache, dizziness, increased nervous irritability, sleep disturbance, drowsiness, tremor, convulsions, nausea, vomiting, diarrhea, exacerbation of gastric ulcer and duodenal ulcer, rapid heartbeat, pink urine may be observed , allergic reactions (rash, urticaria), collapse, bronchospasm.
Overdose
Symptoms: increased manifestations of side effects. Treatment: symptomatic therapy.
Interaction with other drugs
Other beta2-adrenomimetic agents and theophylline increase the effects of salbutamol and increase the likelihood of side effects. Ascoril is not prescribed simultaneously with drugs containing codeine, and other antitussive drugs, since this makes it difficult to discharge liquefied sputum. Ascoril Bromhexine, which is part of the preparation, promotes the penetration of antibiotics (erythromycin, cephalexin, oxytetracycline) into the lung tissue. It is not recommended to use the drug Ascoril concurrently with non-selective beta-adrenergic receptor blockers, such as propranolol. Part of the drug Ascoril salbutamol is not recommended for patients who receive MAO inhibitors.Diuretics and drugs GKS enhance the hypokalemic effect of salbutamol. It is not recommended to take along with the drug Ascoril alkaline drink.
special instructions
It should be carefully taken Ascoril patients with hyperthyroidism, diabetes, severe diseases of the cardiovascular system, arterial hypertension, gastric ulcer and duodenal ulcer.