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Active ingredients
Azelaic acid
Release form
Cream
Composition
Active ingredient: Azelaic acid (Acidum azelaicum) Active ingredient concentration (mg): 200
Pharmacological effect
Remedy for the treatment of acne. It has antimicrobial activity against Propionibacterium acne and Staphylococcus epidermidis. Along with this, it reduces the content of free fatty acids in the lipids of the skin, and also normalizes the impaired keratinization processes in the follicles of the sebaceous glands.
Pharmacokinetics
After application to the skin, azelaic acid penetrates the epidermis and dermis. Part of the absorbed azelaic acid is excreted by the kidneys in unchanged form, and some as dicarboxylic acids (C5, C7), which are formed from azelaic acid as a result of beta-oxidation.
Indications
Common acne (acne vulgaris). Pathological hyperpigmentation, incl. melasma.
Contraindications
Hypersensitivity to the drug components. Children under 12 years old.
Precautionary measures
The drug should be avoided in the eyes, as well as on the mucous membranes of the nose, lips and mouth. If this happens, rinse immediately with plenty of water.
Use during pregnancy and lactation
It is possible to use during pregnancy according to indications. Considering the low systemic bioavailability and low toxicity of azelaic acid, it is possible to use it during lactation (breastfeeding). In experimental studies on laboratory animals, no negative effect of azelaic acid on reproductive function was found, and no embryotoxic and teratogenic effects were identified.
Dosage and administration
The maximum duration of therapy depends on the individual picture of the disease and the severity of symptoms and is set by the attending physician. For adults and children over 12 years old, apply the cream evenly with a thin layer 2 times / day (morning and evening) on previously cleaned (mild cleansing agents and water) and dried areas of the face and, if necessary, neck and upper chest, affected by acne. For the entire surface of the face, about 2.5 cm of tube of cream tube is enough. The drug should be regularly used during the entire course of treatment, the duration of which depends on the severity of the disease. The minimum duration of treatment for melasma is 3 months.During the period of treatment of melasma, sunscreen (UV B and UV A) must be used to prevent exacerbation of the disease and / or re-pigmentation of the skin under the influence of the sun. In patients with acne vulgaris (acne vulgaris), marked improvement is usually observed after 4 weeks. For best results, use of the drug should be continued for several months.
Side effects
On the part of the skin Rareko (mainly at the beginning of therapy): skin irritation, skin flushing, erythema, burning sensation, itching, peeling, which pass on their own during further treatment. You may experience allergic reactions (such as a rash). After applying the cream on the skin of the face, you may experience a burning sensation and tingling that lasts for 15 minutes.
Overdose
Currently, cases of overdose cream Aziks-Derm not described
Interaction with other drugs
The interaction of the drug Aziderm with other drugs to date is not known.
special instructions
In cases of severe skin irritation in the first weeks of treatment, Aziderm can be applied 1 time / day or reduce the amount of cream applied to the skin; short-term withdrawal of the drug is also possible. After the disappearance of symptoms of skin irritation, regular use of the drug at the recommended dose should be resumed. Dermal melasma is insensitive to treatment with the drug. For carrying out differential diagnostics use Wood's lamp. Aziks-Derm can be used in combination with other methods of therapy of acne rash. At the same time, it is possible to correct the dosage regimen of simultaneously applied drugs. Control of vehicles and mechanisms: Aziderm has no effect on the reaction rate when driving or working with other mechanisms.