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Active ingredients
Cyclopirox
Release form
Nail polish
Composition
Cyclopirox 80 mg. Auxiliary substances: copolymer of butylhydromaleate and methoxyethylene (solution 50% in isopropanol), ethyl acetate, isopropanol.
Pharmacological effect
Antifungal broad-spectrum drug. It is active against Trichophyton rubrum, Trichophyton mentagrophytes, Trichophyton verrucosum, Trichophyton tonsurans, Trichophyton quinckeanum, Trichophyton equinum, Trichophyton concentricum, Trichophyton epilans, Trichophyton ferrugineum, Trichophyton gallnae, Trichophyton Schoenleinii, Trichophyton soudanense, Trichophyton terrestre, Trichophyton violaceum, Microsporum canis, Microsporum gypseum Microsporum audouinii, microsporum langeroni, microsporum nanum, epidermophyton floccosum, candida capsulatum, Sporotrichum schenkii, Torulopsis glabrata, Blastomyces dermatitidis, Paracoccidioides brasiliensis, Saccharomyces cerevisiae, Torula Bergeri, Aspergillus fumigalus, Aspergillus flavus, Aspergillus niger, Penicillium chrysus, enicillium notary The antifungal effect of ciclopirox is based on the inhibition of the entry into the cell and the induction of the removal of the components necessary for its vital activity. It has antibacterial action against gram-positive and most gram-negative pathogens. Suppresses the development of mycoplasmas and Trichomonas.
Pharmacokinetics
The values of fungicidal concentrations for one-day use exceed the maximum plasma concentration by 20-30 times (maximum plasma concentration for dermatophytes, Candida, mold and yeast-like fungi - 0.98 - 3.9 mcg / ml, maximum plasma concentration for mycoplasma and Trichomonasvaginalis - 7.8-31.3 mcg / ml).
Indications
- fungal diseases of the nails.
Contraindications
- hypersensitivity to the components of the drug; - due to the lack of clinical experience, the use of the drug Batrafen, nail polish, in children under 10 years old, as well as in women during pregnancy and lactation is not shown.
Precautionary measures
Do not exceed recommended doses.
Use during pregnancy and lactation
Due to the lack of clinical experience, the use of the drug during pregnancy and lactation is contraindicated.
Dosage and administration
Outwardly. Before the first application of the drug Batrafen, nail polish, you should remove with the scissors the maximum possible amount of the affected nail and file the remaining nail plate with a nail file to create an uneven surface. The varnish is applied with a thin layer on the affected nail 1 time a day during the first month, during the second - 2 times a week, during the third - 1 time a week.Once a week (for example, on Sunday), the lacquer is removed with a usual solvent or scraped off after a warm bath, and the growing affected part of the nail plate should be removed again with scissors. If the lacquer coating is damaged during the period between applying the lacquer, then lacquer should be applied again only to those areas of the nail where the lacquer coating is damaged. The duration of treatment depends on the severity of the lesion of the nail plates, but the treatment period should not exceed 6 months.
Side effects
Local reactions (rarely): itching, burning or irritation of the skin, redness and peeling of the skin around the affected nail; allergic reactions.
Overdose
Cases of overdose are not described.
Interaction with other drugs
Drug interaction of the drug is not described.
special instructions
To prevent the varnish from drying out, close the lid tightly after use. To prevent the lid from sticking, avoid varnish on the threads. After opening the bottle, the drug can be used for 6 months if storage conditions are observed. During treatment, it is not recommended to use cosmetic nail polish. With prolonged external use of the drug may cause sensitization.