Bromhexine Akrikhin syrup 4mg 5ml 100ml
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Active ingredients
Bromhexine
Release form
Syrup
Composition
5 ml of syrup contains: Active ingredient: Bromhexine hydrochloride 4 mg.
Pharmacological effect
Mucolytic agent with expectorant action. Reduces the viscosity of bronchial secretions due to the depolarization of the acidic polysaccharides contained in it and stimulation of the secretory cells of the bronchial mucosa, producing a secret containing neutral polysaccharides. Bromhexine is believed to contribute to the formation of surfactant.
Pharmacokinetics
Bromhexine is rapidly absorbed from the gastrointestinal tract and is extensively metabolized during the first passage through the liver. Bioavailability is about 20%. In healthy patients, Cmax in plasma is determined after 1 h. It is widely distributed in body tissues. About 85-90% is excreted in the urine mainly in the form of metabolites. Bromhexine metabolite is Ambroxol. Bromhexine binding to plasma proteins is high. T1 / 2 in the terminal phase is about 12 hours. Bromhexine penetrates the BBB. In small quantities penetrates the placental barrier. Only small amounts are excreted in the urine with a T1 / 2 6.5 h. The clearance of bromhexine or its metabolites may decrease in patients with severe impaired liver and kidney function.
Indications
Diseases of the respiratory tract, accompanied by the formation of viscous secretion difficult to separate: tracheobronchitis, chronic bronchitis with a broncho-obstructive component, bronchial asthma, cystic fibrosis, chronic pneumonia.
Contraindications
Hypersensitivity to Bromhexine.
Dosage and administration
Inside adults and children over 10 years old - 8 mg 3-4 times / day. Children under 2 years old - 2 mg 3 times / day; at the age of 2 to 6 years, 4 mg 3 times / day; between the ages of 6 and 10 years, 6–8 mg 3 times / day. If necessary, the dose can be increased to adults up to 16 mg 4 times / day, children - up to 16 mg 2 times / day. In the form of inhalation for adults - 8 mg each, for children over 10 years old - 4 mg each, at the age of 6-10 years old - 2 mg each. At the age of 6 years - used in doses up to 2 mg. Inhalation spend 2 times / day. The therapeutic effect may occur on the 4-6 day of treatment. Parenteral administration is recommended for treatment in severe cases, as well as in the postoperative period to prevent the accumulation of thick sputum in the bronchi. Enter 2 mg p / c, in / m or / in 2-3 times / day slowly over 2-3 minutes.