Canison plus cream for external approx 15g
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Active ingredients
Betamethasone + Gentamicin + Clotrimazole
Release form
Cream
Composition
Betamethasone dipropionate 640 mcg, clotrimazole 10 mg, gentamicin sulfate 1 mg.
Pharmacological effect
The combined drug has anti-inflammatory, antiallergic, antibacterial and antifungal (fungicidal) effects. Gentamicin is a broad-spectrum antibiotic from the group of aminoglycosides, it is bactericidal. Highly sensitive gram-negative microorganisms - Proteus spp. (indole-positive and indole-negative), Escherichia coli, Klebsiella spp. Salmonella spp., Shigella spp., Campylobacter spp. Staphylococcus spp. (methicillin-resistant). Sensitive: Enterococcus faecalis, Serratia spp., Pseudomonas spp., Acinetobacter spp., Citrobacter spp. (except Streptococcus pneumoniae), Enterococcus faecalis; Providencia rettgeri. Betamethasone - glucocorticosteroid, has a local anti-inflammatory, vasoconstrictor, antiallergic action. Clotrimazole is an antifungal agent from the group of imidazole derivatives for topical use. It has an effect due to a violation of the synthesis of ergosterol, which is an integral part of the cell membrane of fungi. It has a wide spectrum of action. Effective against dermatophytes, mold fungi, fungi of the genus Candida, Malassezia furfur, Corynebacterium minutissimum, Streptococcus spp., Staphylococcus spp., Trichomonas vaginalis.
Indications
- simple and allergic dermatitis (complicated by secondary infection); - atopic dermatitis (including diffuse atopic dermatitis); - eczema; - ringworm (dermatofitii, candidiasis, versatile lichen), especially when localized in the groin area and large skin folds; - simple chronic lichen (limited neurodermatitis).
Contraindications
- tuberculosis of the skin; - skin manifestations of syphilis; - chicken pox; - herpes simplex; - skin post-vaccination reactions; - open wounds; - children under 2 years of age; - indications of hypersensitivity reactions to any of its components in the anamnesis. pregnancy (I term), long-term treatment, use on large areas of the skin or in violation of the integrity of the skin, the use of occlusive dressings (especially in children).
Precautionary measures
Children use the drug prescribed for children only under strict indications and under medical supervision, because possible development of systemic side effects associated with betamethasone.When using Kanizon Plus cream, as well as many other topical preparations based on glucocorticosteroids, on vast surfaces and / or with an occlusive bandage, hypothalamic-pituitary-adrenal gland function may be suppressed, as well as an increase in intracranial pressure.
Use during pregnancy and lactation
The use of the drug in the first trimester of pregnancy is not recommended. In clinical and experimental studies it has not been established that the use of clotrimazole during pregnancy has a negative effect on the health of the woman and the fetus. However, the question of the advisability of prescribing the drug in the II and III trimesters of pregnancy should be decided individually after consulting a doctor. The possibility of excretion of clotrimazole with breast milk has not been studied. Therefore, Canison Plus, a cream for external use should be used with nursing mothers with caution.
Dosage and administration
Outdoor. Kanizon Plus cream should be applied with a thin layer to the entire affected surface of the skin and the surrounding tissue 2 times a day - in the morning and at night. To ensure the effectiveness of treatment Kanizon Plus cream must be applied regularly. The duration of therapy depends on the size and location of the lesion, as well as the patient's response. If clinical improvement does not occur after 3-4 weeks of treatment, this may serve as a reason to clarify the diagnosis.
Side effects
Very rarely, when using Kanizon Plus cream, there are: burning sensation, erythema, exudation, impaired pigmentation and itching. Side effects occurring when using local glucocorticosteroids (especially when using occlusive dressings): burning sensation, itching, dry skin, folliculitis, hypertrichosis, acne , hypopigmentation, perioral dermatitis, allergic contact dermatitis, skin maceration, development of secondary infection, skin atrophy, striae, prickly heat. Side effects caused by clotrimazole: erythema, tingling sensation, phenomenon of blistering, peeling, local swelling, pruritus, urticaria, irritation kozhi.Pobochnye reactions caused gentamycin: transient skin irritation (erythema, itching), not usually requiring treatment discontinuation.
Overdose
Symptoms: long-term use of local glucocorticosteroids in high doses may suppress adrenal function with the development of secondary adrenal insufficiency and symptoms of hypercorticism, including Cushing's syndrome. Overdose of clotrimazole when it is topically applied does not lead to the appearance of any symptoms. also not expected. Long-term treatment with gentamine in high doses can lead to an increase in insensitive flora. Treatment: Sympto mathic The acute symptoms of hypercorticism are usually reversible. If necessary, carry out the correction of electrolyte imbalance. In the case of chronic glucocorticosteroid toxicity, gradual withdrawal of glucocorticosteroids is recommended.
Interaction with other drugs
With simultaneous use of Kanizon Plus with antifungal drugs of other groups, the effectiveness of these drugs used externally decreases. The use of gentamicin can lead to an overgrowth of unresponsive (highly resistant) microorganisms, including fungi. If superinfection occurs as part of a therapeutic course of treatment with gentamicin, discontinue use of the drug and prescribe a course of appropriate therapy.
special instructions
Canis Plus Cream is not intended for use in ophthalmology. Avoid contact with eyes. Long-term topical use of antibiotics can sometimes lead to an increase in resistant microflora. In this case, as well as the development of irritation, sensitization or superinfection during treatment with Kanizon Plus, treatment should be stopped and appropriate therapy should be given. Allergic cross-reactions with aminoglycosidic antibiotics have been observed. Any side effects encountered with the use of systemic corticosteroids, including inhibition of the function of the adrenal cortex, can also be observed with topical application of glucocorticosteroids, especially in children. will be performed on large areas of the skin or when using occlusive dressings, especially with long-term treatment or violation of the integrity of the skin. Gentamicin should be avoided on open wounds and damaged skin.Otherwise, there may be side effects characteristic of gentamicin in its systemic use. Appropriate precautions should be taken in such cases, especially when treating children. With prolonged use of the drug, it is recommended to discontinue it gradually. Use in pediatrics For children, the drug is prescribed only under strict indications and under medical supervision, since possible development of systemic side effects associated with betamethasone. When using Kanizon Plus cream, as well as many other topical preparations based on glucocorticosteroids, on vast surfaces and / or with an occlusive bandage, hypothalamic-pituitary-adrenal gland function may be suppressed, as well as an increase in intracranial pressure.