Cardiomagnyl pills coated 150mg N30
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Active ingredients
Acetylsalicylic acid + Magnesium hydroxide
Release form
Pills
Composition
Acetylsalicylic acid 150 mg, magnesium hydroxide 30.39 mg. Auxiliary substances: corn starch - 19.0 mg, microcrystalline cellulose - 25.0 mg, magnesium stearate - 305 mg, potato starch - 4.0 mg. The composition of the shell: hypromellose (methylhydroxypropylcellulose 15) - 1.2 mg, propylene glycol - 240 mcg, talc - 720 mcg.
Pharmacological effect
NSAIDs, antiplatelet agent. The basis of the mechanism of action of acetylsalicylic acid is irreversible inhibition of the COX-1 enzyme, as a result of which synthesis of thromboxane A2 is blocked and platelet aggregation is inhibited. Acetylsalicylic acid is also believed to have other mechanisms for suppressing platelet aggregation, which expands its field of application in various vascular diseases. Acetylsalicylic acid also has anti-inflammatory, analgesic and antipyretic effects. Magnesium hydroxide, which is part of Cardiomagnyl, protects the gastrointestinal mucosa from the effects of acetylsalicylic acid.
Pharmacokinetics
Absorption: After taking the drug inside acetylsalicylic acid is absorbed from the gastrointestinal tract almost completely. The bioavailability of acetylsalicylic acid is about 70%, but this value is characterized by significant individual variability due to presystemic hydrolysis in the mucous membranes of the gastrointestinal tract and in the liver with the formation of salicylic acid under the action of enzymes. The bioavailability of salicylic acid is 80-100%. Metabolism and excretion: T1 / 2 of acetylsalicylic acid is about 15 minutes, because with the participation of enzymes, it is rapidly hydrolyzed to salicylic acid in the intestine, liver, and blood plasma. T1 / 2 salicylic acid - about 3 hours, but when taking acetylsalicylic acid in high doses (> 3 g), this figure can increase significantly as a result of saturation of enzyme systems. Magnesium hydroxide (in the applied doses) does not affect the bioavailability of acetylsalicylic acid.
Indications
- primary prevention of cardiovascular diseases such as thrombosis and acute heart failure with risk factors (for example, diabetes mellitus, hyperlipidemia, arterial hypertension, obesity, smoking,old age) - prevention of recurrent myocardial infarction and thrombosis of blood vessels — prevention of thromboembolism after surgical interventions on vessels (coronary artery bypass surgery, percutaneous transluminal coronary angioplasty) - unstable angina.
Contraindications
- cerebral hemorrhage — tendency to bleeding (vitamin K deficiency, thrombocytopenia, hemorrhagic diathesis) - bronchial asthma induced by salicylates and NSAIDs — erosive and ulcerative gastrointestinal lesions (in the acute phase) - gastrointestinal bleeding — renal insufficiency of the gastrointestinal tract (acute phase) - gastrointestinal bleeding — renal insufficiency of the gastrointestinal tract (in the acute phase) - gastrointestinal bleeding — renal insufficiency of the gastrointestinal tract (in the acute phase) - gastrointestinal bleeding — renal insufficiency of the gastrointestinal tract (in acute phase) - gastrointestinal bleeding — renal insufficiency of the gastrointestinal tract (in the acute phase) - gastrointestinal bleeding — renal insufficiency of the gastrointestinal tract (in the acute phase) CC <10 ml / min) - deficiency of glucose-6-phosphate dehydrogenase — simultaneous intake with methotrexate (> 15 mg per week) - I and III trimesters of pregnancy — lactation period (breastfeeding) - children and adolescents up to 18 years old - hypersensitivity to acetylsalicylic acid, excipients of the drug and other NPVS.S caution should be prescribed the drug for gout, hyperuricemia, history of ulcerative lesions of the gastrointestinal tract or bleeding from the gastrointestinal tract, with renal and / or hepatic insufficiency, bronchial asthma, hay fever , nasal polyposis, allergic conditions, in the II trimester of pregnancy.
Dosage and administration
Tablets should be swallowed whole with water. If desired, the tablet can be broken in half, chewed or pre-rub. For primary prevention of cardiovascular diseases such as thrombosis and acute heart failure in the presence of risk factors (for example, diabetes mellitus, hyperlipidemia, arterial hypertension, obesity, smoking, old age) are prescribed for 1 tab. Cardiomagnyl containing acetylsalicylic acid in a dose of 150 mg on the first day, then 1 tab. Cardiomagnyl containing acetylsalicylic acid in a dose of 75 mg 1 time / day. For the prevention of recurrent myocardial infarction and thrombosis of blood vessels, 1 tab. Cardiomagnyl containing acetylsalicylic acid in a dose of 75-150 mg 1 time / day. For the prevention of thromboembolism after surgical interventions on the vessels (coronary artery bypass surgery, percutaneous transluminal coronary angioplasty) is prescribed in 1 tab. Cardiomagnyl containing acetylsalicylic acid in a dose of 75-150 mg 1 time / day.With unstable angina prescribed by 1 tab. Cardiomagnyl containing acetylsalicylic acid in a dose of 75-150 mg 1 time / day.