Chondroitin Verte capsules 250mg N50
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Active ingredients
Chondroitin sulfate
Composition
1 caps Chondroitin sodium sulfate 250 mg. Excipients: lactose, calcium stearate.
Pharmacological effect
Stimulator of cartilage tissue regeneration (chondroprotector). High molecular weight mucopolysaccharide, derived from the cartilage of the trachea of cattle. Affects metabolic processes in hyaline and fibrous cartilage, reduces degenerative changes in the cartilage tissue of the joints, stimulates the biosynthesis of glycosaminoglycans. It promotes the regeneration of the cartilaginous surfaces of the joints and the articular sac, increases the production of intraarticular fluid. It slows down bone resorption and reduces calcium loss, accelerates bone repair processes. With drug treatment, pain decreases and mobility of the affected joints improves. The therapeutic effect persists for a long time after the end of the course of treatment.
Pharmacokinetics
Absorption and distribution: After taking the drug inside more than 70% of chondroitin sulfate is absorbed from the gastrointestinal tract. After a single dose by mouth in the average therapeutic dose, Cmax in the blood plasma is reached in 3-4 hours, in synovial fluid - in 4-5 hours. Bioavailability is 13%. Chondroitin sulfate accumulates in the synovial fluid. Excretion: Excreted by the kidneys.
Indications
Degenerative diseases of the joints and spine: - osteoarthrosis - osteochondrosis of the spine.
Contraindications
- children's age up to 15 years - hypersensitivity to the components of the preparation. With caution, the drug should be used in patients with bleeding and a tendency to bleeding, with thrombophlebitis.
Use during pregnancy and lactation
It is not recommended to prescribe the drug during pregnancy and lactation (breastfeeding) due to the lack of sufficient clinical data.
Dosage and administration
The drug is taken orally, during or after a meal, drinking at least 1/2 glass of water. Adults and adolescents aged 15 years and older are prescribed at a dose of 1 g / day - 2 capsules 2 times / day. The recommended duration of the initial course of treatment is 6 months. The period of the drug after its cancellation is 3-5 months, depending on the location and stage of the disease.The duration of repeated courses of treatment the doctor sets individually.
Side effects
On the part of the digestive system: rarely - nausea, vomiting. Allergic reactions: rarely - urticaria, skin erythema, pruritus.
Overdose
Symptoms: rarely - nausea, vomiting, diarrhea; with prolonged use in excessively high doses (more than 3 g / day) hemorrhagic rashes are possible. Treatment: symptomatic treatment.
Interaction with other drugs
With simultaneous use of the drug Chondroitin-AKOS with other drugs may increase the effects of indirect anticoagulants, antiplatelet agents, fibrinolytics.
special instructions
Use in children under 15 years of age is contraindicated due to the lack of accurate data on the efficacy and safety of the drug in this category of patients.