Cordiamine solution 25% 30ml
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Active ingredients
Niketamide
Release form
Solution
Composition
Finasteride. Excipients: lactose monohydrate, pregelatinized starch (maize), sodium starch carboxymethyl ester, iron yellow oxide, sodium duster, microcrystalline cellulose, magnesium stearate. ; Film coating composition: methylhydroxypropylcellulose, hydroxypropylcellulose, titanium dioxide, talc, indigo carmine aluminum varnish;
Pharmacological effect
The reflex influence also partially excites the respiratory center due to excitation of chemoreceptors on the carotid glomeruli. Breathing under the action of the drug Cordiamine quickens and deepens (especially in a depressed state), while in the case of initial hypotension - blood pressure rises. The drug is able to facilitate the transfer of impulses between nerve cells - neurons, which increases the excitability, as well as the sensitivity of the centers to natural stimuli, such as carbon dioxide. ; Cordiamine is not characteristic of a direct stimulating effect on the heart or a vasoconstrictor effect;
Pharmacokinetics
It has a stimulating effect on the central nervous system, and, mainly, on such centers in the medulla oblongata as the respiratory and vasomotor centers. It has good absorbability, regardless of the method of administration;
Indications
Collapse, asphyxia, shock conditions, asphyxia of newborns, circulatory disorders in infectious diseases, poisoning with hypnotics, drugs, barbiturates;
Contraindications
Hypersensitivity, epilepsy, a history of tonic-clonic seizures, hyperthermia in children;
Use during pregnancy and lactation
Contraindicated;
Dosage and administration
Inside (regardless of the meal) or parenteral. ; Adults - 15–40 drops per reception, 2–3 times a day, for children - as many drops per reception as a child is. ; P / C, in / m and / in / in adults administered in a dose of 1-2 ml, 1-3 times a day, children under the skin - 0.1-0.75 ml, depending on age. ; Introduction into the vein should be slow. P / to and / m injection Cordiamine painful; to reduce pain, it is sometimes possible to preliminarily introduce novocaine at the injection site (for adults, 1 ml of 0.5–1% solution, for children, according to age).; Higher doses for adults - inside and under the skin a single 2 ml (60 drops), daily 6 ml (180 drops). The highest single dose under the skin and into a vein in case of poisoning with drugs is 5 ml;
Side effects
Cordiamine can trigger a number of symptoms, which are regarded as side effects. The manifestations of side effects of Cordiamine include the following symptoms: anxiety; muscle twitching, in which the circular muscles of the mouth are primarily involved; redness of the face; itchy skin; vomiting; heart rhythm disorder; swelling and tenderness at the injection site; allergic reactions. ;
Overdose
In case of overdose, patients develop development of tonic-clonic convulsions, agitation, and increase in blood pressure. Intravenous administration of aminophylline is indicated;
Interaction with other drugs
It is impossible to administer ascorbic acid simultaneously with Cordiamine, since they are incompatible. Cordiamine enhances the effect of psychostimulants and antidepressants. But the drug significantly reduces the effects and effects of narcotic painkillers, hypnotics, neuroleptics, tranquilizers, anticonvulsants, Chlorpromazine and Opiniazid. Reserpine increases the risk of seizures with Cordiamine;