Depo-Provera suspension intramuscularly 150mg ml 1ml spri N1
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Active ingredients
Medroxyprogesterone
Release form
Suspension
Pharmacological effect
Progestin Does not possess androgenic and estrogenic activity. Inhibits the secretion of gonadotropic hormones (especially LH). In small doses, inhibits ovulation. It has an inhibitory effect on the changes necessary to prepare the endometrium for implantation of a fertilized egg and increases the viscosity of the mucus of the cervix. In higher doses, it has an antitumor effect in hormone-sensitive malignant neoplasms. This effect is due, apparently, to the action on the receptors of steroid hormones and on the pituitary-gonadal system.
Indications
For use in gynecology: contraception, endometriosis. For use in oncology: additional and palliative treatment for recurrent and metastatic endometrial cancer or kidney cancer. palliative treatment for hormone-dependent forms of recurrent breast cancer in postmenopausal women. prostate carcinoma, some forms of prostate adenoma. cancer cachexia with advanced tumors of various localization.
Contraindications
Pregnancy, hypersensitivity to medroxyprogesterone.
Use during pregnancy and lactation
Contraindicated in pregnancy. Does not affect lactation. It is excreted in breast milk in small quantities, while there are no negative events in the development of children receiving this milk.
Side effects
On the part of the central nervous system: headache, irritability, sleep disturbances, drowsiness, fatigue, depression, dizziness. On the part of the digestive system: nausea. Allergic reactions: urticaria, pruritus, rash, anaphylactoid reactions. From the hemopoietic system: thromboembolic disorders. On the part of the endocrine system: hypersensitivity of the mammary gland, galactorrhea, erosion and changes in cervical secretion. When used at a dose of 500 mg / day or more, acne, hirsutism, weight gain, and a "moon-shaped" face are possible. Other: hyperthermia.
special instructions
On the part of the central nervous system: headache, irritability, sleep disturbances, drowsiness, fatigue, depression, dizziness. On the part of the digestive system: nausea.Allergic reactions: urticaria, pruritus, rash, anaphylactoid reactions. From the hemopoietic system: thromboembolic disorders. On the part of the endocrine system: hypersensitivity of the mammary gland, galactorrhea, erosion and changes in cervical secretion. When used at a dose of 500 mg / day or more, acne, hirsutism, weight gain, and a "moon-shaped" face are possible. Other: hyperthermia.